P49411: Elongation factor Tu, mitochondrial

General Information

Protein names	- Elongation factor Tu, mitochondrial - EF-Tu - P43
Gene names	TUFM
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49411

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAATLLRAT PHFSGLAAGR TFLLQGLLRL LKAPALPLLC RGLAVEAKKT YVRDKPHVNV
        70         80         90        100        110        120
GTIGHVDHGK TTLTAAITKI LAEGGGAKFK KYEEIDNAPE ERARGITINA AHVEYSTAAR
       130        140        150        160        170        180
HYAHTDCPGH ADYVKNMITG TAPLDGCILV VAANDGPMPQ TREHLLLARQ IGVEHVVVYV
       190        200        210        220        230        240
NKADAVQDSE MVELVELEIR ELLTEFGYKG EETPVIVGSA LCALEGRDPE LGLKSVQKLL
       250        260        270        280        290        300
DAVDTYIPVP ARDLEKPFLL PVEAVYSVPG RGTVVTGTLE RGILKKGDEC ELLGHSKNIR
       310        320        330        340        350        360
TVVTGIEMFH KSLERAEAGD NLGALVRGLK REDLRRGLVM VKPGSIKPHQ KVEAQVYILS
       370        380        390        400        410        420
KEEGGRHKPF VSHFMPVMFS LTWDMACRII LPPEKELAMP GEDLKFNLIL RQPMILEKGQ
       430        440        450
RFTLRDGNRT IGTGLVTNTL AMTEEEKNIK WG

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49411-44-	AVEAKK...	44		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49411-44-unknown	AVEAKK...	44	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49411-44-unknown	AVEAKK...	44		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P49411-74-unknown	TAAITK...	74	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14169
P49411-91-	KYEEID...	91		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P49411-91-	KYEEID...	91		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P49411-91-	KYEEID...	91		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49411-91-	KYEEID...	91		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P49411-91-	KYEEID...	91		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49411-110-	AAHVEY...	110		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49411-110-	AAHVEY...	110		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49411-110-	AAHVEY...	110		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49411-124-unknown	HTDCPG...	124	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7509
P49411-126-unknown	DCPGHA...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7510
P49411-245-	TYIPVP...	245		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49411-267-	SVPGRG...	267		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKTTLT	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14169
...ARHYAH	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7509
...HYAHTD	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7510
...NIKWG	452	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	73	TTLT.\|.TAAI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	123	HYAH.\|.HTDC	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	125	AHTD.\|.DCPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)