P49736: DNA replication licensing factor MCM2

General Information

Protein names	- DNA replication licensing factor MCM2 - 3.6.4.12 - Minichromosome maintenance protein 2 homolog - Nuclear protein BM28
Gene names	MCM2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49736

15 N-termini

8 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAESSESFTM ASSPAQRRRG NDPLTSSPGR SSRRTDALTS SPGRDLPPFE DESEGLLGTE
        70         80         90        100        110        120
GPLEEEEDGE ELIGDGMERD YRAIPELDAY EAEGLALDDE DVEELTASQR EAAERAMRQR
       130        140        150        160        170        180
DREAGRGLGR MRRGLLYDSD EEDEERPARK RRQVERATED GEEDEEMIES IENLEDLKGH
       190        200        210        220        230        240
SVREWVSMAG PRLEIHHRFK NFLRTHVDSH GHNVFKERIS DMCKENRESL VVNYEDLAAR
       250        260        270        280        290        300
EHVLAYFLPE APAELLQIFD EAALEVVLAM YPKYDRITNH IHVRISHLPL VEELRSLRQL
       310        320        330        340        350        360
HLNQLIRTSG VVTSCTGVLP QLSMVKYNCN KCNFVLGPFC QSQNQEVKPG SCPECQSAGP
       370        380        390        400        410        420
FEVNMEETIY QNYQRIRIQE SPGKVAAGRL PRSKDAILLA DLVDSCKPGD EIELTGIYHN
       430        440        450        460        470        480
NYDGSLNTAN GFPVFATVIL ANHVAKKDNK VAVGELTDED VKMITSLSKD QQIGEKIFAS
       490        500        510        520        530        540
IAPSIYGHED IKRGLALALF GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS
       550        560        570        580        590        600
SRAIFTTGQG ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI
       610        620        630        640        650        660
HEAMEQQSIS ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTFSENVDLT EPIISRFDIL
       670        680        690        700        710        720
CVVRDTVDPV QDEMLARFVV GSHVRHHPSN KEEEGLANGS AAEPAMPNTY GVEPLPQEVL
       730        740        750        760        770        780
KKYIIYAKER VHPKLNQMDQ DKVAKMYSDL RKESMATGSI PITVRHIESM IRMAEAHARI
       790        800        810        820        830        840
HLRDYVIEDD VNMAIRVMLE SFIDTQKFSV MRSMRKTFAR YLSFRRDNNE LLLFILKQLV
       850        860        870        880        890        900
AEQVTYQRNR FGAQQDTIEV PEKDLVDKAR QINIHNLSAF YDSELFRMNK FSHDLKRKMI

LQQF

Isoforms

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

15 N-termini - 8 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P49736-2-unknown	MAESSE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49736-2-Acetylation	AESSES...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P49736-2-Acetylation	AESSES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P49736-2-Acetylation	AESSES...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P49736-2-Acetylation	AESSES...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P49736-10-unknown	MASSPA...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419802
P49736-10-unknown	MASSPA...	10		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418930
P49736-10-unknown	MASSPA...	10		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P49736-55-	GLLGTE...	55			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-55-	GLLGTE...	55			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49736-55-	GLLGTE...	55			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49736-58-	GTEGPL...	58			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49736-58-	GTEGPL...	58			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49736-69-	GEELIG...	69			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-89-unknown	AYEAEG...	89		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11595
P49736-89-	AYEAEG...	89			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-89-	AYEAEG...	89			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P49736-89-	AYEAEG...	89			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49736-89-	AYEAEG...	89			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49736-94-unknown	GLALDD...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11596
P49736-96-unknown	ALDDED...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14170
P49736-99-unknown	DEDVEE...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11597
P49736-134-	GLLYDS...	134			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P49736-134-	GLLYDS...	134			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-134-	GLLYDS...	134			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P49736-451-	VAVGEL...	451			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-463-	MITSLS...	463			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P49736-699-	GSAAEP...	699			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P49736-699-	GSAAEP...	699			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P49736-699-	GSAAEP...	699			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IPELDA	88	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11595
...AYEAEG	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11596
...EAEGLA	95	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14170
...GLALDD	98	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11597
...SQREAA	112	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000418930
...RGLLYD	137	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419802
...ILQQF	904	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ILQQF	904		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ILQQF	904		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ILQQF	904		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ILQQF	904		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	88	ELDA.\|.AYEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	93	EAEG.\|.GLAL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	95	EGLA.\|.ALDD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	98	ALDD.\|.DEDV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)