P50991: T-complex protein 1 subunit delta

General Information

Protein names	- T-complex protein 1 subunit delta - TCP-1-delta - CCT-delta - Stimulator of TAR RNA-binding
Gene names	CCT4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P50991

16 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPENVAPRSG ATAGAAGGRG KGAYQDRDKP AQIRFSNISA AKAVADAIRT SLGPKGMDKM
        70         80         90        100        110        120
IQDGKGDVTI TNDGATILKQ MQVLHPAARM LVELSKAQDI EAGDGTTSVV IIAGSLLDSC
       130        140        150        160        170        180
TKLLQKGIHP TIISESFQKA LEKGIEILTD MSRPVELSDR ETLLNSATTS LNSKVVSQYS
       190        200        210        220        230        240
SLLSPMSVNA VMKVIDPATA TSVDLRDIKI VKKLGGTIDD CELVEGLVLT QKVSNSGITR
       250        260        270        280        290        300
VEKAKIGLIQ FCLSAPKTDM DNQIVVSDYA QMDRVLREER AYILNLVKQI KKTGCNVLLI
       310        320        330        340        350        360
QKSILRDALS DLALHFLNKM KIMVIKDIER EDIEFICKTI GTKPVAHIDQ FTADMLGSAE
       370        380        390        400        410        420
LAEEVNLNGS GKLLKITGCA SPGKTVTIVV RGSNKLVIEE AERSIHDALC VIRCLVKKRA
       430        440        450        460        470        480
LIAGGGAPEI ELALRLTEYS RTLSGMESYC VRAFADAMEV IPSTLAENAG LNPISTVTEL
       490        500        510        520        530
RNRHAQGEKT AGINVRKGGI SNILEELVVQ PLLVSVSALT LATETVRSIL KIDDVVNTR

Isoforms

- Isoform 2 of T-complex protein 1 subunit delta

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P50991-1-unknown	MPENVA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91751
P50991-2-unknown	PENVAP...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P50991-2-unknown	PENVAP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P50991-2-unknown	PENVAP...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P50991-2-unknown	PENVAP...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110640
P50991-9-unknown	SGATAG...	9		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P50991-9-unknown	SGATAG...	9	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162211
P50991-60-	MIQDGK...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P50991-60-	MIQDGK...	60		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50991-60-	MIQDGK...	60		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P50991-61-unknown	IQDGKG...	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14180
P50991-166-	SATTSL...	166		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50991-166-unknown	SATTSL...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173857
P50991-223-unknown	LVEGLV...	223	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17693
P50991-223-unknown	LVEGLV...	223	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146334
P50991-262-unknown	NQIVVS...	262	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1895
P50991-262-unknown	NQIVVS...	262	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147808
P50991-268-unknown	DYAQMD...	268	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14181
P50991-268-unknown	DYAQMD...	268	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147994
P50991-269-	YAQMDR...	269		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P50991-269-	YAQMDR...	269		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P50991-269-unknown	YAQMDR...	269	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11622
P50991-269-unknown	YAQMDR...	269		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P50991-269-unknown	YAQMDR...	269	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148020
P50991-457-unknown	AMEVIP...	457	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170959
P50991-457-	AMEVIP...	457		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P50991-470-	GLNPIS...	470		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P50991-470-unknown	GLNPIS...	470	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177451

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GMDKMI	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14180
...GMDKMI	60	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153935
...IDDCEL	222	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17693
...IDDCEL	222	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129637
...KTDMDN	261	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1895
...KTDMDN	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131163
...QIVVSD	267	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14181
...QIVVSD	267	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131357
...IVVSDY	268	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11622
...IVVSDY	268	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131383
...VVNTR	539		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VVNTR	539	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VVNTR	539	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt87369
...VVNTR	539		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	60	DKMI.\|.IQDG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	222	DCEL.\|.LVEG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	261	DMDN.\|.NQIV	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> TCPD_HUMAN @261
GRAM_HUMAN	267	VVSD.\|.DYAQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	268	VSDY.\|.YAQM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)