P60900: Proteasome subunit alpha type-6

General Information

Protein names	- Proteasome subunit alpha type-6 - 3.4.25.1 {ECO:0000269\|PubMed:27176742} - 27 kDa prosomal protein - PROS-27 - p27K - Macropain iota chain - Multicatalytic endopeptidase complex iota chain - Proteasome iota chain
Gene names	PSMA6
Organism	Homo sapiens
Protease Family
Protease ID	T01.971
Chromosome location
UniProt ID	P60900

8 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Proteasome subunit alpha type-6 - Isoform 3 of Proteasome subunit alpha type-6

Sequence View

        10         20         30         40         50         60
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL
        70         80         90        100        110        120
LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD
       130        140        150        160        170        180
ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE
       190        200        210        220        230        240
KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV

ALAERD         10         20         30         40         50         60
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL
        70         80         90        100        110        120
LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD
       130        140        150        160        170        180
ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE
       190        200        210        220        230        240
KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV

ALAERD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P60900-1-unknown	MSRGSS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P60900-63-unknown	SSTVTH...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7611
P60900-63-unknown	SSTVTH...	63	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138681
P60900-80-unknown	MTGMTA...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86347
P60900-80-unknown	MTGMTA...	80	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452566
P60900-80-unknown	MTGMTA...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100159
P60900-130-unknown	EMRPLG...	130	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14232
P60900-130-unknown	EMRPLG...	130	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139278
P60900-130-unknown	EMRPLG...	130	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143010
P60900-169-	GVKQTE...	169		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P60900-169-unknown	GVKQTE...	169	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171876
P60900-169-unknown	GVKQTE...	169	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171877
P60900-207-unknown	SIDFKP...	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174010
P60900-207-unknown	SIDFKP...	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174011
P60900-207-	SIDFKP...	207		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P60900-207-	SIDFKP...	207		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DKLLDS	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7611
...DKLLDS	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121735
...YTQNAE	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14232
...YTQNAE	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122353
...YTQNAE	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126219
...LAERD	246	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LAERD	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81965
...LAERD	246	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81964

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	62	LLDS.\|.SSTV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	129	QNAE.\|.EMRP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)