P63241: Eukaryotic translation initiation factor 5A-1

General Information

Protein names	- Eukaryotic translation initiation factor 5A-1 - eIF-5A-1 - eIF-5A1 - Eukaryotic initiation factor 5A isoform 1 - eIF-5A - Rev-binding factor - eIF-4D
Gene names	EIF5A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63241

19 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADDLDFETG DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK HGHAKVHLVG
        70         80         90        100        110        120
IDIFTGKKYE DICPSTHNMD VPNIKRNDFQ LIGIQDGYLS LLQDSGEVRE DLRLPEGDLG
       130        140        150
KEIEQKYDCG EEILITVLSA MTEEAAVAIK AMAK

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 5A-1

Sequence View

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Protein Neighborhood

Domains & Features

19 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63241-1-unknown	MADDLD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107937
P63241-2-unknown	MADDLD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63241-2-Acetylation	ADDLDF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63241-2-Acetylation	ADDLDF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63241-2-Acetylation	ADDLDF...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63241-2-Acetylation	ADDLDF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63241-2-Acetylation	ADDLDF...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P63241-2-Acetylation	ADDLDF...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111496
P63241-7-	FETGDA...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63241-7-unknown	FETGDA...	7			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P63241-7-unknown	FETGDA...	7		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161696
P63241-9-unknown	TGDAGA...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11791
P63241-9-unknown	TGDAGA...	9		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194821
P63241-12-unknown	AGASAT...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11792
P63241-12-unknown	AGASAT...	12			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P63241-12-unknown	AGASAT...	12		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138486
P63241-27-	KNGFVV...	27			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P63241-27-unknown	KNGFVV...	27		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165896
P63241-93-	GIQDGY...	93			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63241-93-	GIQDGY...	93			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P63241-93-unknown	GIQDGY...	93		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170863
P63241-97-	GYLSLL...	97			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P63241-97-	GYLSLL...	97			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P63241-97-	GYLSLL...	97			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P63241-97-unknown	GYLSLL...	97		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11794
P63241-97-unknown	GYLSLL...	97		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143760
P63241-100-unknown	SLLQDS...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182863
P63241-100-	SLLQDS...	100			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P63241-105-unknown	SGEVRE...	105		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11796
P63241-105-unknown	SGEVRE...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144061
P63241-139-	SAMTEE...	139			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P63241-139-unknown	SAMTEE...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176520
P63241-143-unknown	EEAAVA...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7663
P63241-143-unknown	EEAAVA...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145650

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLDFET	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11791
...FETGDA	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11792
...IGIQDG	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11794
...IGIQDG	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127002
...SLLQDS	104	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11796
...SLLQDS	104	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127312
...LSAMTE	142	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7663
...LSAMTE	142	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128949
...KAMAK	154	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KAMAK	154	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73187

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	8	DFET.\|.TGDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	11	TGDA.\|.AGAS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	96	IQDG.\|.GYLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	104	LQDS.\|.SGEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	142	AMTE.\|.EEAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)