P63261: Actin, cytoplasmic 2

General Information

Protein names	- Actin, cytoplasmic 2 - Gamma-actin - Actin, cytoplasmic 2, N-terminally processed
Gene names	ACTG1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P63261

14 N-termini

15 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS
        70         80         90        100        110        120
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT
       130        140        150        160        170        180
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL
       190        200        210        220        230        240
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY
       250        260        270        280        290        300
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
       310        320        330        340        350        360
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ
       370
EYDESGPSIV HRKCF

Isoforms

Sequence View

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P63261-1-unknown	MEEEIA...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63261-1-Acetylation	MEEEIA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63261-1-Acetylation	MEEEIA...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63261-2-unknown	EEEIAA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P63261-2-Acetylation	EEEIAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63261-2-Acetylation	EEEIAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P63261-2-Acetylation	EEEIAA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P63261-2-Acetylation	EEEIAA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P63261-9-unknown	VIDNGS...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14285
P63261-12-unknown	NGSGMC...	12		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1977
P63261-18-unknown	KAGFAG...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15334
P63261-19-unknown	AGFAGD...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10151
P63261-48-unknown	GQKDSY...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14286
P63261-48-unknown	GQKDSY...	48		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P63261-48-unknown	GQKDSY...	48		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
P63261-52-unknown	SYVGDE...	52		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11798
P63261-52-unknown	SYVGDE...	52		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1978
P63261-106-unknown	TEAPLN...	106		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15335
P63261-107-unknown	EAPLNP...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15336
P63261-217-unknown	CYVALD...	217		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14287
P63261-220-unknown	ALDFEQ...	220		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15337

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EIAALV	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14285
...ALVIDN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1977
...GSGMCK	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15334
...SGMCKA	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10151
...VMVGMG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14286
...MGQKDS	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11798
...MGQKDS	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1978
...HPVLLT	105	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15335
...PVLLTE	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15336
...MDSGDG	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466346
...MDSGDG	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471891
...THTVPI	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460660
...THTVPI	164	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000471926
...RDIKEK	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460464
...RDIKEK	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459119
...RDIKEK	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472294
...RDIKEK	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470575
...IKEKLC	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14287
...KLCYVA	219	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15337
...QVITIG	250	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461407
...QVITIG	250	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470489
...HRKCF	375	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	8	AALV.\|.VIDN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	11	VIDN.\|.NGSG	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> ACTG_HUMAN @11
HTRA2_HUMAN	17	GMCK.\|.KAGF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAA_HUMAN	18	MCKA.\|.AGFA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	47	VGMG.\|.GQKD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	51	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP3_HUMAN	51	QKDS.\|.SYVG	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> ACTG_HUMAN @51
HTRA2_HUMAN	105	VLLT.\|.TEAP	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
HTRA2_HUMAN	106	LLTE.\|.EAPL	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
GRAM_HUMAN	216	EKLC.\|.CYVA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
HTRA2_HUMAN	219	CYVA.\|.ALDF	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,

TopFIND

P63261: Actin, cytoplasmic 2

General Information

14

N-termini

15

C-termini

11

Cleavages

0

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

14 N-termini - 15 C-termini - 11 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates