P85037: Forkhead box protein K1 {ECO:0000303|PubMed:15202027, ECO:0000303|PubMed:15289879}

General Information

Protein names	- Forkhead box protein K1 {ECO:0000303\|PubMed:15202027, ECO:0000303\|PubMed:15289879} - Myocyte nuclear factor {ECO:0000303\|PubMed:15289879} - MNF {ECO:0000303\|PubMed:15289879}
Gene names	FOXK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P85037

12 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAEVGEDSGA RALLALRSAP CSPVLCAAAA AAAFPAAAPP PAPAQPQPPP GPPPPPPPPL
        70         80         90        100        110        120
PPGAIAGAGS SGGSSGVSGD SAVAGAAPAL VAAAAASVRQ SPGPALARLE GREFEFLMRQ
       130        140        150        160        170        180
PSVTIGRNSS QGSVDLSMGL SSFISRRHLQ LSFQEPHFYL RCLGKNGVFV DGAFQRRGAP
       190        200        210        220        230        240
ALQLPKQCTF RFPSTAIKIQ FTSLYHKEEA PASPLRPLYP QISPLKIHIP EPDLRSMVSP
       250        260        270        280        290        300
VPSPTGTISV PNSCPASPRG AGSSSYRFVQ NVTSDLQLAA EFAAKAASEQ QADTSGGDSP
       310        320        330        340        350        360
KDESKPPFSY AQLIVQAISS AQDRQLTLSG IYAHITKHYP YYRTADKGWQ NSIRHNLSLN
       370        380        390        400        410        420
RYFIKVPRSQ EEPGKGSFWR IDPASEAKLV EQAFRKRRQR GVSCFRTPFG PLSSRSAPAS
       430        440        450        460        470        480
PTHPGLMSPR SGGLQTPECL SREGSPIPHD PEFGSKLASV PEYRYSQSAP GSPVSAQPVI
       490        500        510        520        530        540
MAVPPRPSSL VAKPVAYMPA SIVTSQQPAG HAIHVVQQAP TVTMVRVVTT SANSANGYIL
       550        560        570        580        590        600
TSQGAAGGSH DAAGAAVLDL GSEARGLEEK PTIAFATIPA AGGVIQTVAS QMAPGVPGHT
       610        620        630        640        650        660
VTILQPATPV TLGQHHLPVR AVTQNGKHAV PTNSLAGNAY ALTSPLQLLA TQASSSAPVV
       670        680        690        700        710        720
VTRVCEVGPK EPAAAVAATA TTTPATATTA SASASSTGEP EVKRSRVEEP SGAVTTPAGV
       730
IAAAGPQGPG TGE

Isoforms

- Isoform 2 of Forkhead box protein K1

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P85037-2-unknown	MAEVGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P85037-2-Acetylation	AEVGED...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P85037-2-Acetylation	AEVGED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P85037-2-Acetylation	AEVGED...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P85037-81-	SAVAGA...	81			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P85037-81-	SAVAGA...	81			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P85037-81-unknown	SAVAGA...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11851
P85037-431-unknown	SGGLQT...	431		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10169
P85037-431-unknown	SGGLQT...	431		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149081
P85037-441-unknown	SREGSP...	441		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14336
P85037-441-unknown	SREGSP...	441		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149281
P85037-496-unknown	AYMPAS...	496		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175987
P85037-496-	AYMPAS...	496			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P85037-650-	ATQASS...	650			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P85037-650-unknown	ATQASS...	650		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168074
P85037-691-unknown	SASASS...	691		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175989
P85037-691-	SASASS...	691			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVSGDS	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11851
...LMSPRS	430	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10169
...LMSPRS	430	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132465
...TPECLS	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14336
...TPECLS	440	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132666
...PGTGE	733	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PGTGE	733	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71003

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	80	SGDS.\|.SAVA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAA_HUMAN	430	SPRS.\|.SGGL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	440	ECLS.\|.SREG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)