Q13123: Protein Red {ECO:0000303|PubMed:10216252}

General Information

Protein names	- Protein Red {ECO:0000303\|PubMed:10216252} - Cytokine IK {ECO:0000303\|PubMed:7970704} - IK factor {ECO:0000303\|PubMed:7970704} - Protein RER
Gene names	IK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13123

10 N-termini

8 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM
        70         80         90        100        110        120
PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI
       130        140        150        160        170        180
STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRAEIAS
       190        200        210        220        230        240
KEKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV
       250        260        270        280        290        300
VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK
       310        320        330        340        350        360
KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER
       370        380        390        400        410        420
ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW
       430        440        450        460        470        480
EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR
       490        500        510        520        530        540
WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE
       550
KRKKMEADGV EVKRPKY

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 8 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13123-1-unknown	MPERDS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13123-10-	SNPLAP...	10		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13123-63-unknown	EYNEDE...	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10220
Q13123-109-	GVNKDY...	109		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13123-109-	GVNKDY...	109		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13123-109-	GVNKDY...	109		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13123-109-	GVNKDY...	109		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13123-128-unknown	AVGPTA...	128		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13123-128-	AVGPTA...	128		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13123-128-	AVGPTA...	128		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13123-128-	AVGPTA...	128		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13123-128-	AVGPTA...	128		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13123-165-unknown	GLDFAL...	165		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13123-325-	YVPSTT...	325		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13123-325-	YVPSTT...	325		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13123-325-	YVPSTT...	325		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13123-325-	YVPSTT...	325		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13123-325-	YVPSTT...	325		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13123-325-unknown	YVPSTT...	325		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13123-452-unknown	TMDDMA...	452	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14401

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HEMPRE	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10220
...RDGVNK	111	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000425564
...VGPTAE	133	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000424622
...FKTRLG	212	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426764
...CPTMEA	267	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422641
...ECYPAT	451	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14401
...KRPKY	557		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KRPKY	557	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KRPKY	557		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	62	MPRE.\|.EYNE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	451	YPAT.\|.TMDD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)