Q13177: Serine/threonine-protein kinase PAK 2

General Information

Protein names	- Serine/threonine-protein kinase PAK 2 - 2.7.11.1 - Gamma-PAK - PAK65 - S6/H4 kinase - p21-activated kinase 2 - PAK-2 - p58 - PAK-2p27 - p27 - PAK-2p34 - p34 - C-t-PAK2
Gene names	PAK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13177

17 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT
        70         80         90        100        110        120
EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP
       130        140        150        160        170        180
QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP
       190        200        210        220        230        240
PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV
       250        260        270        280        290        300
SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE
       310        320        330        340        350        360
LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH
       370        380        390        400        410        420
ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY
       430        440        450        460        470        480
GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC
       490        500        510        520
LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

17 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13177-2-unknown	MSDNGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13177-2-Acetylation	SDNGEL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13177-2-Acetylation	SDNGEL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13177-2-Acetylation	SDNGEL...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13177-2-Acetylation	SDNGEL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13177-2-Acetylation	SDNGEL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q13177-5-	GELEDK...	5			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13177-5-	GELEDK...	5			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13177-29-	DPLSAN...	29			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13177-32-unknown	SANHSL...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14403
Q13177-36-	SLKPLP...	36			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13177-51-	HKIISI...	51			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13177-90-	AVTGEF...	90			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13177-90-	AVTGEF...	90			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13177-118-	KNPQAV...	118			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13177-149-unknown	GFPSGT...	149			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13177-149-unknown	GFPSGT...	149			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q13177-149-	GFPSGT...	149			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q13177-161-	GTEAPA...	161			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13177-161-	GTEAPA...	161			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13177-162-	TEAPAV...	162			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13177-197-unknown	SVIDPV...	197			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13177-197-	SVIDPV...	197			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q13177-197-	SVIDPV...	197			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13177-197-	SVIDPV...	197			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13177-197-	SVIDPV...	197			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13177-213-unknown	GAAKSL...	213		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13177-213-unknown	GAAKSL...	213		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2163
Q13177-225-	TKMTDE...	225			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GKDPLS	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14403
...DSHVDG	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSHVDG	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2163
...MKSNR	524	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	31	DPLS.\|.SANH	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	212	HVDG.\|.GAAK	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> PAK2_HUMAN @212

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)