Q13247: Serine/arginine-rich splicing factor 6

General Information

Protein names	- Serine/arginine-rich splicing factor 6 - Pre-mRNA-splicing factor SRP55 - Splicing factor, arginine/serine-rich 6
Gene names	SRSF6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13247

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SRP55-2 of Serine/arginine-rich splicing factor 6 - Isoform SRP55-3 of Serine/arginine-rich splicing factor 6

Sequence View

        10         20         30         40         50         60
MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL
        70         80         90        100        110        120
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR
       130        140        150        160        170        180
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE
       190        200        210        220        230        240
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG
       250        260        270        280        290        300
RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
       310        320        330        340
SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD         10         20         30         40         50         60
MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL
        70         80         90        100        110        120
CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR
       130        140        150        160        170        180
CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE
       190        200        210        220        230        240
DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG
       250        260        270        280        290        300
RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR
       310        320        330        340
SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13247-1-unknown	MPRVYI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13247-1-unknown	MPRVYI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90739
Q13247-1-unknown	MPRVYI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90740
Q13247-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q13247-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13247-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13247-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q13247-36-	GYGFVE...	36		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q13247-36-unknown	GYGFVE...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168530
Q13247-36-unknown	GYGFVE...	36	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168531
Q13247-100-unknown	DKYGPP...	100	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q13247-100-unknown	DKYGPP...	100	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196952
Q13247-112-unknown	LIVENL...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10223
Q13247-112-unknown	LIVENL...	112	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143093
Q13247-255-unknown	RGSHSH...	255	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12007
Q13247-255-unknown	RGSHSH...	255	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148660

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RTEYRL	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10223
...RTEYRL	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126311
...KPKSDR	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12007
...KPKSDR	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132035
...SSSRD	344	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	111	EYRL.\|.LIVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	254	KSDR.\|.RGSH	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)