Q14694: Ubiquitin carboxyl-terminal hydrolase 10

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 10 - 3.4.19.12 {ECO:0000269\|PubMed:20096447} - Deubiquitinating enzyme 10 - Ubiquitin thioesterase 10 - Ubiquitin-specific-processing protease 10
Gene names	USP10
Organism	Homo sapiens
Protease Family
Protease ID	C19.018
Chromosome location
UniProt ID	Q14694

18 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 10 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 10

Sequence View

        10         20         30         40         50         60
MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG
        70         80         90        100        110        120
VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS
       130        140        150        160        170        180
ALALDGSSNV EAEVLENDGV SGGLGQRERK KKKKRPPGYY SYLKDGGDDS ISTEALVNGH
       190        200        210        220        230        240
ANSAVPNSVS AEDAEFMGDM PPSVTPRTCN SPQNSTDSVS DIVPDSPFPG ALGSDTRTAG
       250        260        270        280        290        300
QPEGGPGADF GQSCFPAEAG RDTLSRTAGA QPCVGTDTTE NLGVANGQIL ESSGEGTATN
       310        320        330        340        350        360
GVELHTTESI DLDPTKPESA SPPADGTGSA SGTLPVSQPK SWASLFHDSK PSSSSPVAYV
       370        380        390        400        410        420
ETKYSPPAIS PLVSEKQVEV KEGLVPVSED PVAIKIAELL ENVTLIHKPV SLQPRGLINK
       430        440        450        460        470        480
GNWCYINATL QALVACPPMY HLMKFIPLYS KVQRPCTSTP MIDSFVRLMN EFTNMPVPPK
       490        500        510        520        530        540
PRQALGDKIV RDIRPGAAFE PTYIYRLLTV NKSSLSEKGR QEDAEEYLGF ILNGLHEEML
       550        560        570        580        590        600
NLKKLLSPSN EKLTISNGPK NHSVNEEEQE EQGEGSEDEW EQVGPRNKTS VTRQADFVQT
       610        620        630        640        650        660
PITGIFGGHI RSVVYQQSSK ESATLQPFFT LQLDIQSDKI RTVQDALESL VARESVQGYT
       670        680        690        700        710        720
TKTKQEVEIS RRVTLEKLPP VLVLHLKRFV YEKTGGCQKL IKNIEYPVDL EISKELLSPG
       730        740        750        760        770        780
VKNKNFKCHR TYRLFAVVYH HGNSATGGHY TTDVFQIGLN GWLRIDDQTV KVINQYQVVK
       790
PTAERTAYLL YYRRVDLL         10         20         30         40         50         60
MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG
        70         80         90        100        110        120
VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS
       130        140        150        160        170        180
ALALDGSSNV EAEVLENDGV SGGLGQRERK KKKKRPPGYY SYLKDGGDDS ISTEALVNGH
       190        200        210        220        230        240
ANSAVPNSVS AEDAEFMGDM PPSVTPRTCN SPQNSTDSVS DIVPDSPFPG ALGSDTRTAG
       250        260        270        280        290        300
QPEGGPGADF GQSCFPAEAG RDTLSRTAGA QPCVGTDTTE NLGVANGQIL ESSGEGTATN
       310        320        330        340        350        360
GVELHTTESI DLDPTKPESA SPPADGTGSA SGTLPVSQPK SWASLFHDSK PSSSSPVAYV
       370        380        390        400        410        420
ETKYSPPAIS PLVSEKQVEV KEGLVPVSED PVAIKIAELL ENVTLIHKPV SLQPRGLINK
       430        440        450        460        470        480
GNWCYINATL QALVACPPMY HLMKFIPLYS KVQRPCTSTP MIDSFVRLMN EFTNMPVPPK
       490        500        510        520        530        540
PRQALGDKIV RDIRPGAAFE PTYIYRLLTV NKSSLSEKGR QEDAEEYLGF ILNGLHEEML
       550        560        570        580        590        600
NLKKLLSPSN EKLTISNGPK NHSVNEEEQE EQGEGSEDEW EQVGPRNKTS VTRQADFVQT
       610        620        630        640        650        660
PITGIFGGHI RSVVYQQSSK ESATLQPFFT LQLDIQSDKI RTVQDALESL VARESVQGYT
       670        680        690        700        710        720
TKTKQEVEIS RRVTLEKLPP VLVLHLKRFV YEKTGGCQKL IKNIEYPVDL EISKELLSPG
       730        740        750        760        770        780
VKNKNFKCHR TYRLFAVVYH HGNSATGGHY TTDVFQIGLN GWLRIDDQTV KVINQYQVVK
       790
PTAERTAYLL YYRRVDLL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14694-2-unknown	MALHSP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14694-2-Acetylation	ALHSPQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14694-2-Acetylation	ALHSPQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111239
Q14694-41-unknown	GTQAVD...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173470
Q14694-41-unknown	GTQAVD...	41		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173471
Q14694-41-	GTQAVD...	41			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14694-63-unknown	EVIEPS...	63		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12265
Q14694-63-unknown	EVIEPS...	63		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140468
Q14694-63-unknown	EVIEPS...	63		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143033
Q14694-125-unknown	DGSSNV...	125		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14497
Q14694-125-unknown	DGSSNV...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143860
Q14694-125-unknown	DGSSNV...	125		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145636
Q14694-126-unknown	GSSNVE...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170868
Q14694-126-unknown	GSSNVE...	126		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170869
Q14694-126-	GSSNVE...	126			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14694-134-unknown	VLENDG...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12268
Q14694-134-unknown	VLENDG...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144233
Q14694-134-unknown	VLENDG...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145982
Q14694-136-unknown	ENDGVS...	136		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14500
Q14694-136-unknown	ENDGVS...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144312
Q14694-136-unknown	ENDGVS...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146034
Q14694-139-unknown	GVSGGL...	139		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1300
Q14694-139-unknown	GVSGGL...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144435
Q14694-139-unknown	GVSGGL...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146124
Q14694-139-	GVSGGL...	139			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14694-218-unknown	SVSDIV...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170865
Q14694-218-unknown	SVSDIV...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170866
Q14694-218-	SVSDIV...	218			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14694-250-unknown	FGQSCF...	250		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12271
Q14694-250-unknown	FGQSCF...	250		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148615
Q14694-250-unknown	FGQSCF...	250		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149824
Q14694-278-unknown	TTENLG...	278		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12274
Q14694-278-unknown	TTENLG...	278		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149409
Q14694-278-unknown	TTENLG...	278		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150458
Q14694-563-	SVNEEE...	563			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14694-563-unknown	SVNEEE...	563		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177076
Q14694-563-unknown	SVNEEE...	563		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177077

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EFGVDE	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12265
...EFGVDE	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123595
...EFGVDE	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126251
...SALALD	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14497
...SALALD	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127104
...SALALD	124	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128935
...NVEAEV	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12268
...NVEAEV	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127486
...NVEAEV	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129281
...EAEVLE	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14500
...EAEVLE	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127572
...EAEVLE	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129333
...VLENDG	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1300
...VLENDG	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127699
...VLENDG	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129425
...GPGADF	249	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12271
...GPGADF	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131989
...GPGADF	249	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133215
...CVGTDT	277	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12274
...CVGTDT	277	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132794
...CVGTDT	277	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133854
...RVDLL	798	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RVDLL	798	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89249
...RVDLL	798	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89248

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	62	GVDE.\|.EVIE	inferred from experiment	unknown	MEROPS		Merops GRAB_HUMAN -> UBP10_HUMAN @62
GRAB_HUMAN	62	GVDE.\|.EVIE	inferred from experiment	unknown	MEROPS	Gevaert K	Plasman K et al.:Probing the efficiency of prote... (S01.010)	21048194,
GRAM_HUMAN	124	LALD.\|.DGSS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	133	EAEV.\|.VLEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	135	EVLE.\|.ENDG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP1_HUMAN	138	ENDG.\|.GVSG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	249	GADF.\|.FGQS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	277	GTDT.\|.TTEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)