Q14839: Chromodomain-helicase-DNA-binding protein 4

General Information

Protein names	- Chromodomain-helicase-DNA-binding protein 4 - CHD-4 - 3.6.4.12 - ATP-dependent helicase CHD4 - Mi-2 autoantigen 218 kDa protein - Mi2-beta
Gene names	CHD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14839

18 N-termini

7 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASGLGSPSP CSAGSEEEDM DALLNNSLPP PHPENEEDPE EDLSETETPK LKKKKKPKKP
        70         80         90        100        110        120
RDPKIPKSKR QKKERMLLCR QLGDSSGEGP EFVEEEEEVA LRSDSEGSDY TPGKKKKKKL
       130        140        150        160        170        180
GPKKEKKSKS KRKEEEEEED DDDDSKEPKS SAQLLEDWGM EDIDHVFSEE DYRTLTNYKA
       190        200        210        220        230        240
FSQFVRPLIA AKNPKIAVSK MMMVLGAKWR EFSTNNPFKG SSGASVAAAA AAAVAVVESM
       250        260        270        280        290        300
VTATEVAPPP PPVEVPIRKA KTKEGKGPNA RRKPKGSPRV PDAKKPKPKK VAPLKIKLGG
       310        320        330        340        350        360
FGSKRKRSSS EDDDLDVESD FDDASINSYS VSDGSTSRSS RSRKKLRTTK KKKKGEEEVT
       370        380        390        400        410        420
AVDGYETDHQ DYCEVCQQGG EIILCDTCPR AYHMVCLDPD MEKAPEGKWS CPHCEKEGIQ
       430        440        450        460        470        480
WEAKEDNSEG EEILEEVGGD LEEEDDHHME FCRVCKDGGE LLCCDTCPSS YHIHCLNPPL
       490        500        510        520        530        540
PEIPNGEWLC PRCTCPALKG KVQKILIWKW GQPPSPTPVP RPPDADPNTP SPKPLEGRPE
       550        560        570        580        590        600
RQFFVKWQGM SYWHCSWVSE LQLELHCQVM FRNYQRKNDM DEPPSGDFGG DEEKSRKRKN
       610        620        630        640        650        660
KDPKFAEMEE RFYRYGIKPE WMMIHRILNH SVDKKGHVHY LIKWRDLPYD QASWESEDVE
       670        680        690        700        710        720
IQDYDLFKQS YWNHRELMRG EEGRPGKKLK KVKLRKLERP PETPTVDPTV KYERQPEYLD
       730        740        750        760        770        780
ATGGTLHPYQ MEGLNWLRFS WAQGTDTILA DEMGLGKTVQ TAVFLYSLYK EGHSKGPFLV
       790        800        810        820        830        840
SAPLSTIINW EREFEMWAPD MYVVTYVGDK DSRAIIRENE FSFEDNAIRG GKKASRMKKE
       850        860        870        880        890        900
ASVKFHVLLT SYELITIDMA ILGSIDWACL IVDEAHRLKN NQSKFFRVLN GYSLQHKLLL
       910        920        930        940        950        960
TGTPLQNNLE ELFHLLNFLT PERFHNLEGF LEEFADIAKE DQIKKLHDML GPHMLRRLKA
       970        980        990       1000       1010       1020
DVFKNMPSKT ELIVRVELSP MQKKYYKYIL TRNFEALNAR GGGNQVSLLN VVMDLKKCCN
      1030       1040       1050       1060       1070       1080
HPYLFPVAAM EAPKMPNGMY DGSALIRASG KLLLLQKMLK NLKEGGHRVL IFSQMTKMLD
      1090       1100       1110       1120       1130       1140
LLEDFLEHEG YKYERIDGGI TGNMRQEAID RFNAPGAQQF CFLLSTRAGG LGINLATADT
      1150       1160       1170       1180       1190       1200
VIIYDSDWNP HNDIQAFSRA HRIGQNKKVM IYRFVTRASV EERITQVAKK KMMLTHLVVR
      1210       1220       1230       1240       1250       1260
PGLGSKTGSM SKQELDDILK FGTEELFKDE ATDGGGDNKE GEDSSVIHYD DKAIERLLDR
      1270       1280       1290       1300       1310       1320
NQDETEDTEL QGMNEYLSSF KVAQYVVREE EMGEEEEVER EIIKQEESVD PDYWEKLLRH
      1330       1340       1350       1360       1370       1380
HYEQQQEDLA RNLGKGKRIR KQVNYNDGSQ EDRDWQDDQS DNQSDYSVAS EEGDEDFDER
      1390       1400       1410       1420       1430       1440
SEAPRRPSRK GLRNDKDKPL PPLLARVGGN IEVLGFNARQ RKAFLNAIMR YGMPPQDAFT
      1450       1460       1470       1480       1490       1500
TQWLVRDLRG KSEKEFKAYV SLFMRHLCEP GADGAETFAD GVPREGLSRQ HVLTRIGVMS
      1510       1520       1530       1540       1550       1560
LIRKKVQEFE HVNGRWSMPE LAEVEENKKM SQPGSPSPKT PTPSTPGDTQ PNTPAPVPPA
      1570       1580       1590       1600       1610       1620
EDGIKIEENS LKEEESIEGE KEVKSTAPET AIECTQAPAP ASEDEKVVVE PPEGEEKVEK
      1630       1640       1650       1660       1670       1680
AEVKERTEEP METEPKGAAD VEKVEEKSAI DLTPIVVEDK EEKKEEEEKK EVMLQNGETP
      1690       1700       1710       1720       1730       1740
KDLNDEKQKK NIKQRFMFNI ADGGFTELHS LWQNEERAAT VTKKTYEIWH RRHDYWLLAG
      1750       1760       1770       1780       1790       1800
IINHGYARWQ DIQNDPRYAI LNEPFKGEMN RGNFLEIKNK FLARRFKLLE QALVIEEQLR
      1810       1820       1830       1840       1850       1860
RAAYLNMSED PSHPSMALNT RFAEVECLAE SHQHLSKESM AGNKPANAVL HKVLKQLEEL
      1870       1880       1890       1900       1910
LSDMKADVTR LPATIARIPP VAVRLQMSER NILSRLANRA PEPTPQQVAQ QQ

Isoforms

- Isoform 2 of Chromodomain-helicase-DNA-binding protein 4

Sequence View

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Evidence Codes:

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Protein Neighborhood

Domains & Features

18 N-termini - 7 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14839-1-unknown	MASGLG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14839-1-unknown	MASGLG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70512
Q14839-239-	SMVTAT...	239		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14839-239-unknown	SMVTAT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167077
Q14839-246-unknown	VAPPPP...	246	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167075
Q14839-246-	VAPPPP...	246		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14839-246-	VAPPPP...	246		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14839-246-	VAPPPP...	246		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14839-246-	VAPPPP...	246		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14839-295-unknown	KIKLGG...	295	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14503
Q14839-295-unknown	KIKLGG...	295	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149750
Q14839-321-unknown	FDDASI...	321	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12282
Q14839-321-unknown	FDDASI...	321	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150375
Q14839-588-unknown	FGGDEE...	588	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12284
Q14839-588-unknown	FGGDEE...	588	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154442
Q14839-721-	ATGGTL...	721		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14839-721-unknown	ATGGTL...	721	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177667
Q14839-965-	NMPSKT...	965		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14839-965-unknown	NMPSKT...	965	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177669
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14839-1234-	GGGDNK...	1234		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14839-1234-unknown	GGGDNK...	1234		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14839-1234-unknown	GGGDNK...	1234	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161379
Q14839-1366-	YSVASE...	1366		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14839-1366-unknown	YSVASE...	1366	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176752
Q14839-1367-	SVASEE...	1367		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14839-1367-unknown	SVASEE...	1367	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176750

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SKSKRK	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444614
...SKSKRK	132	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt154740
...KVAPLK	294	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14503
...KVAPLK	294	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133139
...DVESDF	320	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12282
...DVESDF	320	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133772
...KKKKKG	354	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437506
...PPSGDF	587	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12284
...PPSGDF	587	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137863
...VAQQQ	1912		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VAQQQ	1912		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...VAQQQ	1912	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...VAQQQ	1912	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66130
...VAQQQ	1912		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...VAQQQ	1912		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	294	APLK.\|.KIKL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	320	ESDF.\|.FDDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	587	SGDF.\|.FGGD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)