Q15427: Splicing factor 3B subunit 4

General Information

Protein names	- Splicing factor 3B subunit 4 - Pre-mRNA-splicing factor SF3b 49 kDa subunit - Spliceosome-associated protein 49 - SAP 49
Gene names	SF3B4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15427

10 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGPISERN QDATVYVGGL DEKVSEPLLW ELFLQAGPVV NTHMPKDRVT GQHQGYGFVE
        70         80         90        100        110        120
FLSEEDADYA IKIMNMIKLY GKPIRVNKAS AHNKNLDVGA NIFIGNLDPE IDEKLLYDTF
       130        140        150        160        170        180
SAFGVILQTP KIMRDPDTGN SKGYAFINFA SFDASDAAIE AMNGQYLCNR PITVSYAFKK
       190        200        210        220        230        240
DSKGERHGSA AERLLAAQNP LSQADRPHQL FADAPPPPSA PNPVVSSLGS GLPPPGMPPP
       250        260        270        280        290        300
GSFPPPVPPP GALPPGIPPA MPPPPMPPGA AGHGPPSAGT PGAGHPGHGH SHPHPFPPGG
       310        320        330        340        350        360
MPHPGMSQMQ LAHHGPHGLG HPHAGPPGSG GQPPPRPPPG MPHPGPPPMG MPPRGPPFGS
       370        380        390        400        410        420
PMGHPGPMPP HGMRGPPPLM PPHGYTGPPR PPPYGYQRGP LPPPRPTPRP PVPPRGPLRG

PLPQ

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15427-2-unknown	MAAGPI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15427-1-acetylation	MAAGPI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15427-1-acetylation	MAAGPI...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15427-2-	AAGPIS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15427-2-Acetylation	AAGPIS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15427-2-Acetylation	AAGPIS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15427-2-Acetylation	AAGPIS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15427-2-Acetylation	AAGPIS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15427-2-Acetylation	AAGPIS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q15427-13-	ATVYVG...	13			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15427-33-	FLQAGP...	33			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15427-35-	QAGPVV...	35			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15427-44-unknown	MPKDRV...	44		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391114
Q15427-44-unknown	MPKDRV...	44		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463044
Q15427-121-	SAFGVI...	121			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15427-121-	SAFGVI...	121			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15427-121-	SAFGVI...	121			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15427-198-unknown	QNPLSQ...	198		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4097

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RLLAAQ	197	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4097
...GSGLPP	233	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391114
...GSGLPP	233	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463044
...GPLPQ	424	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	197	LAAQ.\|.QNPL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)