Q53T59: HCLS1-binding protein 3

General Information

Protein names	- HCLS1-binding protein 3 - HS1-binding protein 3 - HSP1BP-3
Gene names	HS1BP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q53T59

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQSPAVLVTS RRLQNAHTGL DLTVPQHQEV RGKMMSGHVE YQILVVTRLA AFKSAKHRPE
        70         80         90        100        110        120
DVVQFLVSKK YSEIEEFYQK LSSRYAAASL PPLPRKVLFV GESDIRERRA VFNEILRCVS
       130        140        150        160        170        180
KDAELAGSPE LLEFLGTRSP GAAGLTSRDS SVLDGTDSQT GNDEEAFDFF EEQDQVAEEG
       190        200        210        220        230        240
PPVQSLKGED AEESLEEEEA LDPLGIMRSK KPKKHPKVAV KAKPSPRLTI FDEEVDPDEG
       250        260        270        280        290        300
LFGPGRKLSP QDPSEDVSSV DPLKLFDDPD LGGAIPLGDS LLLPAACESG GPTPSLSHRD
       310        320        330        340        350        360
ASKELFRVEE DLDQILNLGA EPKPKPQLKP KPPVAAKPVI PRKPAVPPKA GPAEAVAGQQ
       370        380        390
KPQEQIQAMD EMDILQYIQD HDTPAQAAPS LF

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q53T59-1-Acetylation	MQSPAV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q53T59-1-Acetylation	MQSPAV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q53T59-1-Acetylation	MQSPAV...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q53T59-182-unknown	PVQSLK...	182		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000392203
Q53T59-185-	SLKGED...	185			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q53T59-185-	SLKGED...	185			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q53T59-239-unknown	EGLFGP...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12459
Q53T59-273-	GAIPLG...	273			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...EVDPDE	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12459
	...APSLF	392	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	238	DPDE.\|.EGLF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)