Q5UIP0: Telomere-associated protein RIF1 {ECO:0000305}
Protein names | - Telomere-associated protein RIF1 {ECO:0000305} - Rap1-interacting factor 1 homolog {ECO:0000305|PubMed:15342490} |
---|---|
Gene names | RIF1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q5UIP0 |
10
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE KKLPRLYKVL
70 80 90 100 110 120
KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL LSKLNDTIKN SDKNVRTRAL
130 140 150 160 170 180
WVISKQTFPS EVVGKMVSSI IDSLEILFNK GETHSAVVDF EALNVIVRLI EQAPIQMGEE
190 200 210 220 230 240
AVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IASITEQLMT TKLISELQKL
250 260 270 280 290 300
FMSKNETYVL KLWPLFVKLL GRTLHRSGSF INSLLQLEEL GFRSGAPMIK KIAFIAWKSL
310 320 330 340 350 360
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PHLPANFEQV
370 380 390 400 410 420
CVPLIQSTIS IDSNASPQGN SCHVATSPGL NPMTPVHKGA SSPYGAPGTP RMNLSSNLGG
430 440 450 460 470 480
MATIPSIQLL GLEMLLHFLL GPEALSFAKQ NKLVLSLEPL EHPLISSPSF FSKHANTLIT
490 500 510 520 530 540
AVHDSFVAVG KDAPDVVVSA IWKELISLVK SVTESGNKKE KPGSEVLTLL LKSLESIVKS
550 560 570 580 590 600
EVFPVSKTLV LMEITIKGLP QKVLGSPAYQ VANMDILNGT PALFLIQLIF NNFLECGVSD
610 620 630 640 650 660
ERFFLSLESL VGCVLSGPTS PLAFSDSVLN VINQNAKQLE NKEHLWKMWS VIVTPLTELI
670 680 690 700 710 720
NQTNEVNQGD ALEHNFSAIY GALTLPVNHI FSEQRFPVAT MKTLLRTWSE LYRAFARCAA
730 740 750 760 770 780
LVATAEENLC CEELSSKIMS SLEDEGFSNL LFVDRIIYII TVMVDCIDFS PYNIKYQPKV
790 800 810 820 830 840
KSPQRPSDWS KKKNEPLGKL TSLFKLIVKV IYSFHTLSFK EAHSDTLFTI GNSITGIISS
850 860 870 880 890 900
VLGHISLPSM IRKIFATLTR PLALFYENSK LDEVPKVYSC LNNKLEKLLG EIIACLQFSY
910 920 930 940 950 960
TGTYDSELLE QLSPLLCIIF LHKNKQIRKQ SAQFWNATFA KVMMLVYPEE LKPVLTQAKQ
970 980 990 1000 1010 1020
KFLLLLPGLE TVEMMEESSG PYSDGTENSQ LNVKISGMER KSNGKRDSFL AQTKNKKENM
1030 1040 1050 1060 1070 1080
KPAAKLKLES SSLKVKGEIL LEEEKSTDFV FIPPEGKDAK ERILTDHQKE VLKTKRCDIP
1090 1100 1110 1120 1130 1140
AMYNNLDVSQ DTLFTQYSQE EPMEIPTLTR KPKEDSKMMI TEEQMDSDIV IPQDVTEDCG
1150 1160 1170 1180 1190 1200
MAEHLEKSSL SNNECGSLDK TSPEMSNSNN DERKKALISS RKTSTECASS TENSFVVSSS
1210 1220 1230 1240 1250 1260
SVSNTTVAGT PPYPTSRRQT FITLEKFDGS ENRPFSPSPL NNISSTVTVK NNQETMIKTD
1270 1280 1290 1300 1310 1320
FLPKAKQREG TFSKSDSEKI VNGTKRSSRR AGKAEQTGNK RSKPLMRSEP EKNTEESVEG
1330 1340 1350 1360 1370 1380
IVVLENNPPG LLNQTECVSD NQVHLSESTM EHDNTKLKAA TVENAVLLET NTVEEKNVEI
1390 1400 1410 1420 1430 1440
NLESKENTPP VVISADQMVN EDSQVQITPN QKTLRRSSRR RSEVVESTTE SQDKENSHQK
1450 1460 1470 1480 1490 1500
KERRKEEEKP LQKSPLHIKD DVLPKQKLIA EQTLQENLIE KGSNLHEKTL GETSANAETE
1510 1520 1530 1540 1550 1560
QNKKKADPEN IKSEGDGTQD IVDKSSEKLV RGRTRYQTRR ASQGLLSSIE NSESDSSEAK
1570 1580 1590 1600 1610 1620
EEGSRKKRSG KWKNKSNESV DIQDQEEKVV KQECIKAENQ SHDYKATSEE DVSIKSPICE
1630 1640 1650 1660 1670 1680
KQDESNTVIC QDSTVTSDLL QVPDDLPNVC EEKNETSKYA EYSFTSLPVP ESNLRTRNAI
1690 1700 1710 1720 1730 1740
KRLHKRDSFD NCSLGESSKI GISDISSLSE KTFQTLECQH KRSRRVRRSK GCDCCGEKSQ
1750 1760 1770 1780 1790 1800
PQEKSLIGLK NTENNDVEIS ETKKADVQAP VSPSETSQAN PYSEGQFLDE HHSVNFHLGL
1810 1820 1830 1840 1850 1860
KEDNDTINDS LIVSETKSKE NTMQESLPSG IVNFREEICD MDSSEAMSLE SQESPNENFK
1870 1880 1890 1900 1910 1920
TVGPCLGDSK NVSQESLETK EEKPEETPKM ELSLENVTVE GNACKVTESN LEKAKTMELN
1930 1940 1950 1960 1970 1980
VGNEASFHGQ ERTKTGISEE AAIEENKRND DSEADTAKLN AKEVATEEFN SDISLSDNTT
1990 2000 2010 2020 2030 2040
PVKLNAQTEI SEQTAAGELD GGNDVSDLHS SEETNTKMKN NEEMMIGEAM AETGHDGETE
2050 2060 2070 2080 2090 2100
NEGITTKTSK PDEAETNMLT AEMDNFVCDT VEMSTEEGII DANKTETNTE YSKSEEKLDN
2110 2120 2130 2140 2150 2160
NQMVMESDIL QEDHHTSQKV EEPSQCLASG TAISELIIED NNASPQKLRE LDPSLVSAND
2170 2180 2190 2200 2210 2220
SPSGMQTRCV WSPLASPSTS ILKRGLKRSQ EDEISSPVNK VRRVSFADPI YQAGLADDID
2230 2240 2250 2260 2270 2280
RRCSIVRSHS SNSSPIGKSV KTSPTTQSKH NTTSAKGFLS PGSRSPKFKS SKKCLISEMA
2290 2300 2310 2320 2330 2340
KESIPCPTES VYPPLVNCVA PVDIILPQIT SNMWARGLGQ LIRAKNIKTI GDLSTLTASE
2350 2360 2370 2380 2390 2400
IKTLPIRSPK VSNVKKALRI YHEQQVKTRG LEEIPVFDIS EKTVNGIENK SLSPDEERLV
2410 2420 2430 2440 2450 2460
SDIIDPVALE IPLSKNLLAQ ISALALQLDS EDLHNYSGSQ LFEMHEKLSC MANSVIKNLQ
2470
SRWRSPSHEN SI
Isoforms
- Isoform 2 of Telomere-associated protein RIF1Sequence View
10 20 30 40 50 60
MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE KKLPRLYKVL
70 80 90 100 110 120
KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL LSKLNDTIKN SDKNVRTRAL
130 140 150 160 170 180
WVISKQTFPS EVVGKMVSSI IDSLEILFNK GETHSAVVDF EALNVIVRLI EQAPIQMGEE
190 200 210 220 230 240
AVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IASITEQLMT TKLISELQKL
250 260 270 280 290 300
FMSKNETYVL KLWPLFVKLL GRTLHRSGSF INSLLQLEEL GFRSGAPMIK KIAFIAWKSL
310 320 330 340 350 360
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PHLPANFEQV
370 380 390 400 410 420
CVPLIQSTIS IDSNASPQGN SCHVATSPGL NPMTPVHKGA SSPYGAPGTP RMNLSSNLGG
430 440 450 460 470 480
MATIPSIQLL GLEMLLHFLL GPEALSFAKQ NKLVLSLEPL EHPLISSPSF FSKHANTLIT
490 500 510 520 530 540
AVHDSFVAVG KDAPDVVVSA IWKELISLVK SVTESGNKKE KPGSEVLTLL LKSLESIVKS
550 560 570 580 590 600
EVFPVSKTLV LMEITIKGLP QKVLGSPAYQ VANMDILNGT PALFLIQLIF NNFLECGVSD
610 620 630 640 650 660
ERFFLSLESL VGCVLSGPTS PLAFSDSVLN VINQNAKQLE NKEHLWKMWS VIVTPLTELI
670 680 690 700 710 720
NQTNEVNQGD ALEHNFSAIY GALTLPVNHI FSEQRFPVAT MKTLLRTWSE LYRAFARCAA
730 740 750 760 770 780
LVATAEENLC CEELSSKIMS SLEDEGFSNL LFVDRIIYII TVMVDCIDFS PYNIKYQPKV
790 800 810 820 830 840
KSPQRPSDWS KKKNEPLGKL TSLFKLIVKV IYSFHTLSFK EAHSDTLFTI GNSITGIISS
850 860 870 880 890 900
VLGHISLPSM IRKIFATLTR PLALFYENSK LDEVPKVYSC LNNKLEKLLG EIIACLQFSY
910 920 930 940 950 960
TGTYDSELLE QLSPLLCIIF LHKNKQIRKQ SAQFWNATFA KVMMLVYPEE LKPVLTQAKQ
970 980 990 1000 1010 1020
KFLLLLPGLE TVEMMEESSG PYSDGTENSQ LNVKISGMER KSNGKRDSFL AQTKNKKENM
1030 1040 1050 1060 1070 1080
KPAAKLKLES SSLKVKGEIL LEEEKSTDFV FIPPEGKDAK ERILTDHQKE VLKTKRCDIP
1090 1100 1110 1120 1130 1140
AMYNNLDVSQ DTLFTQYSQE EPMEIPTLTR KPKEDSKMMI TEEQMDSDIV IPQDVTEDCG
1150 1160 1170 1180 1190 1200
MAEHLEKSSL SNNECGSLDK TSPEMSNSNN DERKKALISS RKTSTECASS TENSFVVSSS
1210 1220 1230 1240 1250 1260
SVSNTTVAGT PPYPTSRRQT FITLEKFDGS ENRPFSPSPL NNISSTVTVK NNQETMIKTD
1270 1280 1290 1300 1310 1320
FLPKAKQREG TFSKSDSEKI VNGTKRSSRR AGKAEQTGNK RSKPLMRSEP EKNTEESVEG
1330 1340 1350 1360 1370 1380
IVVLENNPPG LLNQTECVSD NQVHLSESTM EHDNTKLKAA TVENAVLLET NTVEEKNVEI
1390 1400 1410 1420 1430 1440
NLESKENTPP VVISADQMVN EDSQVQITPN QKTLRRSSRR RSEVVESTTE SQDKENSHQK
1450 1460 1470 1480 1490 1500
KERRKEEEKP LQKSPLHIKD DVLPKQKLIA EQTLQENLIE KGSNLHEKTL GETSANAETE
1510 1520 1530 1540 1550 1560
QNKKKADPEN IKSEGDGTQD IVDKSSEKLV RGRTRYQTRR ASQGLLSSIE NSESDSSEAK
1570 1580 1590 1600 1610 1620
EEGSRKKRSG KWKNKSNESV DIQDQEEKVV KQECIKAENQ SHDYKATSEE DVSIKSPICE
1630 1640 1650 1660 1670 1680
KQDESNTVIC QDSTVTSDLL QVPDDLPNVC EEKNETSKYA EYSFTSLPVP ESNLRTRNAI
1690 1700 1710 1720 1730 1740
KRLHKRDSFD NCSLGESSKI GISDISSLSE KTFQTLECQH KRSRRVRRSK GCDCCGEKSQ
1750 1760 1770 1780 1790 1800
PQEKSLIGLK NTENNDVEIS ETKKADVQAP VSPSETSQAN PYSEGQFLDE HHSVNFHLGL
1810 1820 1830 1840 1850 1860
KEDNDTINDS LIVSETKSKE NTMQESLPSG IVNFREEICD MDSSEAMSLE SQESPNENFK
1870 1880 1890 1900 1910 1920
TVGPCLGDSK NVSQESLETK EEKPEETPKM ELSLENVTVE GNACKVTESN LEKAKTMELN
1930 1940 1950 1960 1970 1980
VGNEASFHGQ ERTKTGISEE AAIEENKRND DSEADTAKLN AKEVATEEFN SDISLSDNTT
1990 2000 2010 2020 2030 2040
PVKLNAQTEI SEQTAAGELD GGNDVSDLHS SEETNTKMKN NEEMMIGEAM AETGHDGETE
2050 2060 2070 2080 2090 2100
NEGITTKTSK PDEAETNMLT AEMDNFVCDT VEMSTEEGII DANKTETNTE YSKSEEKLDN
2110 2120 2130 2140 2150 2160
NQMVMESDIL QEDHHTSQKV EEPSQCLASG TAISELIIED NNASPQKLRE LDPSLVSAND
2170 2180 2190 2200 2210 2220
SPSGMQTRCV WSPLASPSTS ILKRGLKRSQ EDEISSPVNK VRRVSFADPI YQAGLADDID
2230 2240 2250 2260 2270 2280
RRCSIVRSHS SNSSPIGKSV KTSPTTQSKH NTTSAKGFLS PGSRSPKFKS SKKCLISEMA
2290 2300 2310 2320 2330 2340
KESIPCPTES VYPPLVNCVA PVDIILPQIT SNMWARGLGQ LIRAKNIKTI GDLSTLTASE
2350 2360 2370 2380 2390 2400
IKTLPIRSPK VSNVKKALRI YHEQQVKTRG LEEIPVFDIS EKTVNGIENK SLSPDEERLV
2410 2420 2430 2440 2450 2460
SDIIDPVALE IPLSKNLLAQ ISALALQLDS EDLHNYSGSQ LFEMHEKLSC MANSVIKNLQ
2470
SRWRSPSHEN SI
Protein Neighborhood
Domains & Features
10 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q5UIP0-1-unknown | MTARGQ... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q5UIP0-1-unknown | MTARGQ... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87724 | |||
Q5UIP0-1140-unknown | GMAEHL... | 1140 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5UIP0-1140-unknown | GMAEHL... | 1140 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162009 | |||
Q5UIP0-1397-unknown | QMVNED... | 1397 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12531 | |||
Q5UIP0-1397-unknown | QMVNED... | 1397 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt158034 | |||
Q5UIP0-1810-unknown | SLIVSE... | 1810 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170999 | |||
Q5UIP0-1810- | SLIVSE... | 1810 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5UIP0-1846-unknown | AMSLES... | 1846 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170997 | |||
Q5UIP0-1846- | AMSLES... | 1846 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5UIP0-1846- | AMSLES... | 1846 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q5UIP0-2001- | GGNDVS... | 2001 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
Q5UIP0-2001- | GGNDVS... | 2001 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q5UIP0-2001-unknown | GGNDVS... | 2001 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5UIP0-2001-unknown | GGNDVS... | 2001 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162007 | |||
Q5UIP0-2216-unknown | ADDIDR... | 2216 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14579 | |||
Q5UIP0-2216-unknown | ADDIDR... | 2216 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt159033 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...VISADQ | 1396 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12531 | |||
...VISADQ | 1396 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt141529 | |||
...YQAGLA | 2215 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14579 | |||
...YQAGLA | 2215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt142537 | |||
...HENSI | 2472 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...HENSI | 2472 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt83342 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 1396 | SADQ.|.QMVN | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAM_HUMAN | 2215 | AGLA.|.ADDI | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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