Q6FI81: Anamorsin {ECO:0000255|HAMAP-Rule:MF_03115}

General Information

Protein names	- Anamorsin {ECO:0000255\|HAMAP-Rule:MF_03115} - Cytokine-induced apoptosis inhibitor 1 {ECO:0000255\|HAMAP-Rule:MF_03115} - Fe-S cluster assembly protein DRE2 homolog {ECO:0000255\|HAMAP-Rule:MF_03115}
Gene names	CIAPIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6FI81

12 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Anamorsin - Isoform 3 of Anamorsin

Sequence View

        10         20         30         40         50         60
MADFGISAGQ FVAVVWDKSS PVEALKGLVD KLQALTGNEG RVSVENIKQL LQSAHKESSF
        70         80         90        100        110        120
DIILSGLVPG STTLHSAEIL AEIARILRPG GCLFLKEPVE TAVDNNSKVK TASKLCSALT
       130        140        150        160        170        180
LSGLVEVKEL QREPLTPEEV QSVREHLGHE SDNLLFVQIT GKKPNFEVGS SRQLKLSITK
       190        200        210        220        230        240
KSSPSVKPAV DPAAAKLWTL SANDMEDDSM DLIDSDELLD PEDLKKPDPA SLRAASCGEG
       250        260        270        280        290        300
KKRKACKNCT CGLAEELEKE KSREQMSSQP KSACGNCYLG DAFRCASCPY LGMPAFKPGE
       310
KVLLSDSNLH DA         10         20         30         40         50         60
MADFGISAGQ FVAVVWDKSS PVEALKGLVD KLQALTGNEG RVSVENIKQL LQSAHKESSF
        70         80         90        100        110        120
DIILSGLVPG STTLHSAEIL AEIARILRPG GCLFLKEPVE TAVDNNSKVK TASKLCSALT
       130        140        150        160        170        180
LSGLVEVKEL QREPLTPEEV QSVREHLGHE SDNLLFVQIT GKKPNFEVGS SRQLKLSITK
       190        200        210        220        230        240
KSSPSVKPAV DPAAAKLWTL SANDMEDDSM DLIDSDELLD PEDLKKPDPA SLRAASCGEG
       250        260        270        280        290        300
KKRKACKNCT CGLAEELEKE KSREQMSSQP KSACGNCYLG DAFRCASCPY LGMPAFKPGE
       310
KVLLSDSNLH DA

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6FI81-1-unknown	MADFGI...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6FI81-1-unknown	MADFGI...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71559
Q6FI81-181-unknown	KSSPSV...	181		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q6FI81-181-unknown	KSSPSV...	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159560
Q6FI81-181-	KSSPSV...	181		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6FI81-182-unknown	SSPSVK...	182	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168896
Q6FI81-182-	SSPSVK...	182		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q6FI81-182-	SSPSVK...	182		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q6FI81-205-unknown	MEDDSM...	205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71558
Q6FI81-205-unknown	MEDDSM...	205	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103480
Q6FI81-209-unknown	SMDLID...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173796
Q6FI81-209-unknown	SMDLID...	209	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173795
Q6FI81-209-	SMDLID...	209		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6FI81-215-unknown	SDELLD...	215	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171743
Q6FI81-215-unknown	SDELLD...	215	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171742
Q6FI81-215-	SDELLD...	215		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6FI81-215-	SDELLD...	215		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6FI81-215-	SDELLD...	215		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q6FI81-217-unknown	ELLDPE...	217	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12567
Q6FI81-217-unknown	ELLDPE...	217	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136395
Q6FI81-217-unknown	ELLDPE...	217	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146658
Q6FI81-277-unknown	CYLGDA...	277	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14599
Q6FI81-277-unknown	CYLGDA...	277	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140805
Q6FI81-277-unknown	CYLGDA...	277	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148941

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LIDSDE	216	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12567
...LIDSDE	216	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129968
...SACGNC	276	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14599
...SACGNC	276	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123943
...SACGNC	276	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132322
...NLHDA	312	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NLHDA	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67176
...NLHDA	312	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67177

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	216	DSDE.\|.ELLD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	276	CGNC.\|.CYLG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)