Q7KZ85: Transcription elongation factor SPT6

General Information

Protein names	- Transcription elongation factor SPT6 - hSPT6 - Histone chaperone suppressor of Ty6 - Tat-cotransactivator 2 protein - Tat-CT2 protein
Gene names	SUPT6H
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7KZ85

14 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Transcription elongation factor SPT6 - Isoform 3 of Transcription elongation factor SPT6

Sequence View

        10         20         30         40         50         60
MSDFVESEAE ESEEEYNDEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE QGNLKGFIND
        70         80         90        100        110        120
DDDEDEGEED EGSDSGDSED DVGHKKRKRT SFDDRLEDDD FDLIEENLGV KVKRGQKYRR
       130        140        150        160        170        180
VKKMSDDEDD DEEEYGKEEH EKEAIAEEIF QDGEGEEGQE AMEAPMAPPE EEEEDDEESD
       190        200        210        220        230        240
IDDFIVDDDG QPLKKPKWRK KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEEY
       250        260        270        280        290        300
EYEDDEAEGE IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL
       310        320        330        340        350        360
RSIPVKGAED DELEEEADWI YRNAFATPTI SLQESCDYLD RGQPASSFSR KGPSTIQKIK
       370        380        390        400        410        420
EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD EKWTQLRIRK ENLTRLFEKM
       430        440        450        460        470        480
QAYQYEQISA DPDKPLADGI RALDTTDMER LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN
       490        500        510        520        530        540
AAKASRKKLK RVREEGDEEG EGDEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG
       550        560        570        580        590        600
LTPEQFGENL RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP
       610        620        630        640        650        660
LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD DQFLKICLAE
       670        680        690        700        710        720
DEGLLTTDIS IDLKGVEGYG NDQTYFEEIK QFYYRDEFSH QVQEWNRQRT MAIERALQQF
       730        740        750        760        770        780
LYVQMAKELK NKLLAEAKEY VIKACSRKLY NWLRVAPYRP DQQVEEDDDF MDENQGKGIR
       790        800        810        820        830        840
VLGIAFSSAR DHPVFCALVN GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL
       850        860        870        880        890        900
LNKKPHVVTV AGENRDAQML IEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE
       910        920        930        940        950        960
AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV KEELLNALYC
       970        980        990       1000       1010       1020
EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL LKILKQNNTR LESRTQLVTM
      1030       1040       1050       1060       1070       1080
CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI EVLDGSRVHP ETYEWARKMA VDALEYDESA
      1090       1100       1110       1120       1130       1140
EDANPAGALE EILENPERLK DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA
      1150       1160       1170       1180       1190       1200
YRSPNTEEIF NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF
      1210       1220       1230       1240       1250       1260
CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV KRPEERVKVG
      1270       1280       1290       1300       1310       1320
MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY YDFDAEAADH KQEEDMKRKQ
      1330       1340       1350       1360       1370       1380
QRTTYIKRVI AHPSFHNINF KQAEKMMETM DQGDVIIRPS SKGENHLTVT WKVSDGIYQH
      1390       1400       1410       1420       1430       1440
VDVREEGKEN AFSLGATLWI NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR
      1450       1460       1470       1480       1490       1500
KKLEELLIKT KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI
      1510       1520       1530       1540       1550       1560
FPTVNGLFRW FKDHYQDPVP GITPSSSSRT RTPASINATP ANINLADLTR AVNALPQNMT
      1570       1580       1590       1600       1610       1620
SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA YHVFPTPAQQ PVATPLMTPS
      1630       1640       1650       1660       1670       1680
YSYTTPSQPI TTPQYHQLQA STTPQSAQAQ PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ
      1690       1700       1710       1720
WLQEKEAERR KQKQRLTPRP SPSPMIESTP MSIAGDATPL LDEMDR         10         20         30         40         50         60
MSDFVESEAE ESEEEYNDEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE QGNLKGFIND
        70         80         90        100        110        120
DDDEDEGEED EGSDSGDSED DVGHKKRKRT SFDDRLEDDD FDLIEENLGV KVKRGQKYRR
       130        140        150        160        170        180
VKKMSDDEDD DEEEYGKEEH EKEAIAEEIF QDGEGEEGQE AMEAPMAPPE EEEEDDEESD
       190        200        210        220        230        240
IDDFIVDDDG QPLKKPKWRK KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEEY
       250        260        270        280        290        300
EYEDDEAEGE IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL
       310        320        330        340        350        360
RSIPVKGAED DELEEEADWI YRNAFATPTI SLQESCDYLD RGQPASSFSR KGPSTIQKIK
       370        380        390        400        410        420
EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD EKWTQLRIRK ENLTRLFEKM
       430        440        450        460        470        480
QAYQYEQISA DPDKPLADGI RALDTTDMER LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN
       490        500        510        520        530        540
AAKASRKKLK RVREEGDEEG EGDEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG
       550        560        570        580        590        600
LTPEQFGENL RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP
       610        620        630        640        650        660
LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD DQFLKICLAE
       670        680        690        700        710        720
DEGLLTTDIS IDLKGVEGYG NDQTYFEEIK QFYYRDEFSH QVQEWNRQRT MAIERALQQF
       730        740        750        760        770        780
LYVQMAKELK NKLLAEAKEY VIKACSRKLY NWLRVAPYRP DQQVEEDDDF MDENQGKGIR
       790        800        810        820        830        840
VLGIAFSSAR DHPVFCALVN GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL
       850        860        870        880        890        900
LNKKPHVVTV AGENRDAQML IEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE
       910        920        930        940        950        960
AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV KEELLNALYC
       970        980        990       1000       1010       1020
EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL LKILKQNNTR LESRTQLVTM
      1030       1040       1050       1060       1070       1080
CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI EVLDGSRVHP ETYEWARKMA VDALEYDESA
      1090       1100       1110       1120       1130       1140
EDANPAGALE EILENPERLK DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA
      1150       1160       1170       1180       1190       1200
YRSPNTEEIF NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF
      1210       1220       1230       1240       1250       1260
CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV KRPEERVKVG
      1270       1280       1290       1300       1310       1320
MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY YDFDAEAADH KQEEDMKRKQ
      1330       1340       1350       1360       1370       1380
QRTTYIKRVI AHPSFHNINF KQAEKMMETM DQGDVIIRPS SKGENHLTVT WKVSDGIYQH
      1390       1400       1410       1420       1430       1440
VDVREEGKEN AFSLGATLWI NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR
      1450       1460       1470       1480       1490       1500
KKLEELLIKT KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI
      1510       1520       1530       1540       1550       1560
FPTVNGLFRW FKDHYQDPVP GITPSSSSRT RTPASINATP ANINLADLTR AVNALPQNMT
      1570       1580       1590       1600       1610       1620
SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA YHVFPTPAQQ PVATPLMTPS
      1630       1640       1650       1660       1670       1680
YSYTTPSQPI TTPQYHQLQA STTPQSAQAQ PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ
      1690       1700       1710       1720
WLQEKEAERR KQKQRLTPRP SPSPMIESTP MSIAGDATPL LDEMDR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

14 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7KZ85-1-unknown	MSDFVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90558
Q7KZ85-2-unknown	MSDFVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7KZ85-2-Acetylation	SDFVES...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7KZ85-2-Acetylation	SDFVES...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110495
Q7KZ85-107-unknown	NLGVKV...	107		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12660
Q7KZ85-107-unknown	NLGVKV...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142751
Q7KZ85-108-unknown	LGVKVK...	108		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12662
Q7KZ85-108-unknown	LGVKVK...	108		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142827
Q7KZ85-267-unknown	SIFEMY...	267		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177867
Q7KZ85-267-	SIFEMY...	267			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q7KZ85-279-unknown	SSHLTD...	279		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7923
Q7KZ85-279-unknown	SSHLTD...	279		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149326
Q7KZ85-302-	SIPVKG...	302			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZ85-302-	SIPVKG...	302			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZ85-302-unknown	SIPVKG...	302		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171380
Q7KZ85-768-unknown	DDFMDE...	768		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12664
Q7KZ85-1048-	SYIEVL...	1048			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZ85-1048-	SYIEVL...	1048			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q7KZ85-1048-	SYIEVL...	1048			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q7KZ85-1641-unknown	STTPQS...	1641		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168435
Q7KZ85-1641-unknown	STTPQS...	1641		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168434
Q7KZ85-1641-	STTPQS...	1641			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7KZ85-1641-	STTPQS...	1641			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7KZ85-1641-	STTPQS...	1641			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLIEEN	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12660
...DLIEEN	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125955
...LIEENL	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12662
...LIEENL	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126033
...PSELES	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7923
...PSELES	278	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132711
...QVEEDD	767	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12664
...DEMDR	1726	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DEMDR	1726	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86175
...DEMDR	1726	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86176

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	106	IEEN.\|.NLGV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	107	EENL.\|.LGVK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	278	ELES.\|.SSHL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	767	EEDD.\|.DDFM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)