Q86UX7: Fermitin family homolog 3

General Information

Protein names	- Fermitin family homolog 3 - Kindlin-3 - MIG2-like protein - Unc-112-related protein 2
Gene names	FERMT3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86UX7

7 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGMKTASGD YIDSSWELRV FVGEEDPEAE SVTLRVTGES HIGGVLLKIV EQINRKQDWS
        70         80         90        100        110        120
DHAIWWEQKR QWLLQTHWTL DKYGILADAR LFFGPQHRPV ILRLPNRRAL RLRASFSQPL
       130        140        150        160        170        180
FQAVAAICRL LSIRHPEELS LLRAPEKKEK KKKEKEPEEE LYDLSKVVLA GGVAPALFRG
       190        200        210        220        230        240
MPAHFSDSAQ TEACYHMLSR PQPPPDPLLL QRLPRPSSLS DKTQLHSRWL DSSRCLMQQG
       250        260        270        280        290        300
IKAGDALWLR FKYYSFFDLD PKTDPVRLTQ LYEQARWDLL LEEIDCTEEE MMVFAALQYH
       310        320        330        340        350        360
INKLSQSGEV GEPAGTDPGL DDLDVALSNL EVKLEGSAPT DVLDSLTTIP ELKDHLRIFR
       370        380        390        400        410        420
IPRRPRKLTL KGYRQHWVVF KETTLSYYKS QDEAPGDPIQ QLNLKGCEVV PDVNVSGQKF
       430        440        450        460        470        480
CIKLLVPSPE GMSEIYLRCQ DEQQYARWMA GCRLASKGRT MADSSYTSEV QAILAFLSLQ
       490        500        510        520        530        540
RTGSGGPGNH PHGPDASAEG LNPYGLVAPR FQRKFKAKQL TPRILEAHQN VAQLSLAEAQ
       550        560        570        580        590        600
LRFIQAWQSL PDFGISYVMV RFKGSRKDEI LGIANNRLIR IDLAVGDVVK TWRFSNMRQW
       610        620        630        640        650        660
NVNWDIRQVA IEFDEHINVA FSCVSASCRI VHEYIGGYIF LSTRERARGE ELDEDLFLQL

TGGHEAF

Isoforms

- Isoform 2 of Fermitin family homolog 3

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86UX7-1-unknown	MAGMKT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86UX7-1-unknown	MAGMKT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93971
Q86UX7-2-acetylation	AGMKTA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q86UX7-2-acetylation	AGMKTA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183149
Q86UX7-337-	SAPTDV...	337			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86UX7-337-	SAPTDV...	337			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86UX7-337-unknown	SAPTDV...	337		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167230
Q86UX7-345-unknown	SLTTIP...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1316
Q86UX7-345-unknown	SLTTIP...	345			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86UX7-345-	SLTTIP...	345			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86UX7-496-unknown	ASAEGL...	496		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12753
Q86UX7-496-unknown	ASAEGL...	496		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153330

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TDVLDS	344	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1316
...TDVLDS	344	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134240
...PHGPDA	495	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12753
...PHGPDA	495	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt136754
...GHEAF	667	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GHEAF	667	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89589
...GHEAF	667		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GHEAF	667		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	344	VLDS.\|.SLTT	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	495	GPDA.\|.ASAE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)