Q86VM9: Zinc finger CCCH domain-containing protein 18

General Information

Protein names	- Zinc finger CCCH domain-containing protein 18 - Nuclear protein NHN1
Gene names	ZC3H18
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86VM9

10 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDVAESPERD PHSPEDEEQP QGLSDDDILR DSGSDQDLDG AGVRASDLED EESAARGPSQ
        70         80         90        100        110        120
EEEDNHSDEE DRASEPKSQD QDSEVNELSR GPTSSPCEEE GDEGEEDRTS DLRDEASSVT
       130        140        150        160        170        180
RELDEHELDY DEEVPEEPAP AVQEDEAEKA GAEDDEEKGE GTPREEGKAG VQSVGEKESL
       190        200        210        220        230        240
EAAKEKKKED DDGEIDDGEI DDDDLEEGEV KDPSDRKVRP RPTCRFFMKG NCTWGMNCRF
       250        260        270        280        290        300
IHPGVNDKGN YSLITKADPF PPNGAPPLGP HPLMPANPWG GPVVDEILPP PPPEPPTESA
       310        320        330        340        350        360
WERGLRHAKE VLKKATIRKE QEPDFEEKRF TVTIGEDERE FDKENEVFRD WNSRIPRDVR
       370        380        390        400        410        420
DTVLEPYADP YYDYEIERFW RGGQYENFRV QYTETEPYHN YRERERERER ENRQRERERE
       430        440        450        460        470        480
RERDRERERR QRERERERER ERDKERQRRK EEWERERAKR DEKDRQHRDR DREKEREKEK
       490        500        510        520        530        540
GKPKPRSPQP PSRQAEPPKK EAATTGPQVK RADEWKDPWR RSKSPKKKLG VSVSPSRARR
       550        560        570        580        590        600
RRKTSASSAS ASNSSRSSSR SSSYSGSGSS RSRSRSSSYS SYSSRSSRHS SFSGSRSRSR
       610        620        630        640        650        660
SFSSSPSPSP TPSPHRPSIR TKGEPAPPPG KAGEKSVKKP APPPAPPQAT KTTAPVPEPT
       670        680        690        700        710        720
KPGDPREARR KERPARTPPR RRTLSGSGSG SGSSYSGSSS RSRSLSVSSV SSVSSATSSS
       730        740        750        760        770        780
SSAHSVDSED MYADLASPVS SASSRSPAPA QTRKEKGKSK KEDGVKEEKR KRDSSTQPPK
       790        800        810        820        830        840
SAKPPAGGKS SQQPSTPQQA PPGQPQQGTF VAHKEIKLTL LNKAADKGSR KRYEPSDKDR
       850        860        870        880        890        900
QSPPPAKRPN TSPDRGSRDR KSGGRLGSPK PERQRGQNSK APAAPADRKR QLSPQSKSSS
       910        920        930        940        950
KVTSVPGKAS DPGAASTKSG KASTLSRREE LLKQLKAVED AIARKRAKIP GKA

Isoforms

- Isoform 2 of Zinc finger CCCH domain-containing protein 18

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86VM9-1-Acetylation	MDVAES...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86VM9-1-Acetylation	MDVAES...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98858
Q86VM9-1-unknown	MDVAES...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95032
Q86VM9-204-unknown	DLEEGE...	204		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12765
Q86VM9-204-unknown	DLEEGE...	204		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146687
Q86VM9-362-unknown	TVLEPY...	362		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172004
Q86VM9-362-	TVLEPY...	362			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86VM9-362-	TVLEPY...	362			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86VM9-362-	TVLEPY...	362			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86VM9-362-	TVLEPY...	362			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q86VM9-685-unknown	SGSGSG...	685		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14694
Q86VM9-733-	ADLASP...	733			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86VM9-733-unknown	ADLASP...	733			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86VM9-735-unknown	LASPVS...	735		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12767
Q86VM9-821-unknown	LNKAAD...	821		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14695

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EIDDDD	203	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12765
...EIDDDD	203	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129997
...RRRTLS	684	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14694
...DMYADL	734	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12767
...IKLTLL	820	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14695
...IPGKA	953	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...IPGKA	953		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IPGKA	953		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	203	DDDD.\|.DLEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	684	RTLS.\|.SGSG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	734	YADL.\|.LASP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	820	LTLL.\|.LNKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)