Q86VP6: Cullin-associated NEDD8-dissociated protein 1

General Information

Protein names	- Cullin-associated NEDD8-dissociated protein 1 - Cullin-associated and neddylation-dissociated protein 1 - TBP-interacting protein of 120 kDa A - TBP-interacting protein 120A - p120 CAND1
Gene names	CAND1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86VP6

9 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cullin-associated NEDD8-dissociated protein 1 - Isoform 3 of Cullin-associated NEDD8-dissociated protein 1

Sequence View

        10         20         30         40         50         60
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV KMILKLLEDK
        70         80         90        100        110        120
NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE QLRDISSIGL KTVIGELPPA
       130        140        150        160        170        180
SSGSALAANV CKKITGRLTS AIAKQEDVSV QLEALDIMAD MLSRQGGLLV NFHPSILTCL
       190        200        210        220        230        240
LPQLTSPRLA VRKRTIIALG HLVMSCGNIV FVDLIEHLLS ELSKNDSMST TRTYIQCIAA
       250        260        270        280        290        300
ISRQAGHRIG EYLEKIIPLV VKFCNVDDDE LREYCIQAFE SFVRRCPKEV YPHVSTIINI
       310        320        330        340        350        360
CLKYLTYDPN YNYDDEDEDE NAMDADGGDD DDQGSDDEYS DDDDMSWKVR RAAAKCLDAV
       370        380        390        400        410        420
VSTRHEMLPE FYKTVSPALI SRFKEREENV KADVFHAYLS LLKQTRPVQS WLCDPDAMEQ
       430        440        450        460        470        480
GETPLTMLQS QVPNIVKALH KQMKEKSVKT RQCCFNMLTE LVNVLPGALT QHIPVLVPGI
       490        500        510        520        530        540
IFSLNDKSSS SNLKIDALSC LYVILCNHSP QVFHPHVQAL VPPVVACVGD PFYKITSEAL
       550        560        570        580        590        600
LVTQQLVKVI RPLDQPSSFD ATPYIKDLFT CTIKRLKAAD IDQEVKERAI SCMGQIICNL
       610        620        630        640        650        660
GDNLGSDLPN TLQIFLERLK NEITRLTTVK ALTLIAGSPL KIDLRPVLGE GVPILASFLR
       670        680        690        700        710        720
KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL ISESDMHVSQ MAISFLTTLA
       730        740        750        760        770        780
KVYPSSLSKI SGSILNELIG LVRSPLLQGG ALSAMLDFFQ ALVVTGTNNL GYMDLLRMLT
       790        800        810        820        830        840
GPVYSQSTAL THKQSYYSIA KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL
       850        860        870        880        890        900
SLGEVGHHID LSGQLELKSV ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT
       910        920        930        940        950        960
SQPKRQYLLL HSLKEIISSA SVVGLKPYVE NIWALLLKHC ECAEEGTRNV VAECLGKLTL
       970        980        990       1000       1010       1020
IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI DPLLKNCIGD FLKTLEDPDL
      1030       1040       1050       1060       1070       1080
NVRRVALVTF NSAAHNKPSL IRDLLDTVLP HLYNETKVRK ELIREVEMGP FKHTVDDGLD
      1090       1100       1110       1120       1130       1140
IRKAAFECMY TLLDSCLDRL DIFEFLNHVE DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ
      1150       1160       1170       1180       1190       1200
RLDRLVEPLR ATCTTKVKAN SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS
      1210       1220       1230
QISSNPELAA IFESIQKDSS STNLESMDTS         10         20         30         40         50         60
MASASYHISN LLEKMTSSDK DFRFMATNDL MTELQKDSIK LDDDSERKVV KMILKLLEDK
        70         80         90        100        110        120
NGEVQNLAVK CLGPLVSKVK EYQVETIVDT LCTNMLSDKE QLRDISSIGL KTVIGELPPA
       130        140        150        160        170        180
SSGSALAANV CKKITGRLTS AIAKQEDVSV QLEALDIMAD MLSRQGGLLV NFHPSILTCL
       190        200        210        220        230        240
LPQLTSPRLA VRKRTIIALG HLVMSCGNIV FVDLIEHLLS ELSKNDSMST TRTYIQCIAA
       250        260        270        280        290        300
ISRQAGHRIG EYLEKIIPLV VKFCNVDDDE LREYCIQAFE SFVRRCPKEV YPHVSTIINI
       310        320        330        340        350        360
CLKYLTYDPN YNYDDEDEDE NAMDADGGDD DDQGSDDEYS DDDDMSWKVR RAAAKCLDAV
       370        380        390        400        410        420
VSTRHEMLPE FYKTVSPALI SRFKEREENV KADVFHAYLS LLKQTRPVQS WLCDPDAMEQ
       430        440        450        460        470        480
GETPLTMLQS QVPNIVKALH KQMKEKSVKT RQCCFNMLTE LVNVLPGALT QHIPVLVPGI
       490        500        510        520        530        540
IFSLNDKSSS SNLKIDALSC LYVILCNHSP QVFHPHVQAL VPPVVACVGD PFYKITSEAL
       550        560        570        580        590        600
LVTQQLVKVI RPLDQPSSFD ATPYIKDLFT CTIKRLKAAD IDQEVKERAI SCMGQIICNL
       610        620        630        640        650        660
GDNLGSDLPN TLQIFLERLK NEITRLTTVK ALTLIAGSPL KIDLRPVLGE GVPILASFLR
       670        680        690        700        710        720
KNQRALKLGT LSALDILIKN YSDSLTAAMI DAVLDELPPL ISESDMHVSQ MAISFLTTLA
       730        740        750        760        770        780
KVYPSSLSKI SGSILNELIG LVRSPLLQGG ALSAMLDFFQ ALVVTGTNNL GYMDLLRMLT
       790        800        810        820        830        840
GPVYSQSTAL THKQSYYSIA KCVAALTRAC PKEGPAVVGQ FIQDVKNSRS TDSIRLLALL
       850        860        870        880        890        900
SLGEVGHHID LSGQLELKSV ILEAFSSPSE EVKSAASYAL GSISVGNLPE YLPFVLQEIT
       910        920        930        940        950        960
SQPKRQYLLL HSLKEIISSA SVVGLKPYVE NIWALLLKHC ECAEEGTRNV VAECLGKLTL
       970        980        990       1000       1010       1020
IDPETLLPRL KGYLISGSSY ARSSVVTAVK FTISDHPQPI DPLLKNCIGD FLKTLEDPDL
      1030       1040       1050       1060       1070       1080
NVRRVALVTF NSAAHNKPSL IRDLLDTVLP HLYNETKVRK ELIREVEMGP FKHTVDDGLD
      1090       1100       1110       1120       1130       1140
IRKAAFECMY TLLDSCLDRL DIFEFLNHVE DGLKDHYDIK MLTFLMLVRL STLCPSAVLQ
      1150       1160       1170       1180       1190       1200
RLDRLVEPLR ATCTTKVKAN SVKQEFEKQD ELKRSAMRAV AALLTIPEAE KSPLMSEFQS
      1210       1220       1230
QISSNPELAA IFESIQKDSS STNLESMDTS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q86VP6-1-unknown	MASASY...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69254
Q86VP6-2-unknown	MASASY...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86VP6-2-Acetylation	ASASYH...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86VP6-2-Acetylation	ASASYH...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q86VP6-2-Acetylation	ASASYH...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q86VP6-2-Acetylation	ASASYH...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110536
Q86VP6-25-unknown	MATNDL...	25		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437594
Q86VP6-25-unknown	MATNDL...	25		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130985
Q86VP6-158-unknown	MADMLS...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69255
Q86VP6-158-unknown	MADMLS...	158		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103535
Q86VP6-293-unknown	HVSTII...	293		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444089
Q86VP6-293-unknown	HVSTII...	293		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130988
Q86VP6-293-unknown	HVSTII...	293		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt130987
Q86VP6-817-unknown	VVGQFI...	817		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4152
Q86VP6-817-unknown	VVGQFI...	817		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155293
Q86VP6-995-unknown	DHPQPI...	995		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7938
Q86VP6-995-unknown	DHPQPI...	995		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156591
Q86VP6-996-unknown	HPQPID...	996		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18024
Q86VP6-996-unknown	HPQPID...	996		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156600

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PLVSKV	78	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437594
...PLVSKV	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt110855
...KEGPAV	816	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4152
...KEGPAV	816	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138726
...KFTISD	994	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7938
...KFTISD	994	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140076
...FTISDH	995	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18024
...FTISDH	995	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140085
...SMDTS	1230	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SMDTS	1230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64872

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	816	GPAV.\|.VVGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	994	TISD.\|.DHPQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	995	ISDH.\|.HPQP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)