Q8TD19: Serine/threonine-protein kinase Nek9

General Information

Protein names	- Serine/threonine-protein kinase Nek9 - 2.7.11.1 - Nercc1 kinase - Never in mitosis A-related kinase 9 - NimA-related protein kinase 9 - NimA-related kinase 8 - Nek8
Gene names	NEK9
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TD19

8 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVLGEYERH CDSINSDFGS ESGGCGDSSP GPSASQGPRA GGGAAEQEEL HYIPIRVLGR
        70         80         90        100        110        120
GAFGEATLYR RTEDDSLVVW KEVDLTRLSE KERRDALNEI VILALLQHDN IIAYYNHFMD
       130        140        150        160        170        180
NTTLLIELEY CNGGNLYDKI LRQKDKLFEE EMVVWYLFQI VSAVSCIHKA GILHRDIKTL
       190        200        210        220        230        240
NIFLTKANLI KLGDYGLAKK LNSEYSMAET LVGTPYYMSP ELCQGVKYNF KSDIWAVGCV
       250        260        270        280        290        300
IFELLTLKRT FDATNPLNLC VKIVQGIRAM EVDSSQYSLE LIQMVHSCLD QDPEQRPTAD
       310        320        330        340        350        360
ELLDRPLLRK RRREMEEKVT LLNAPTKRPR SSTVTEAPIA VVTSRTSEVY VWGGGKSTPQ
       370        380        390        400        410        420
KLDVIKSGCS ARQVCAGNTH FAVVTVEKEL YTWVNMQGGT KLHGQLGHGD KASYRQPKHV
       430        440        450        460        470        480
EKLQGKAIRQ VSCGDDFTVC VTDEGQLYAF GSDYYGCMGV DKVAGPEVLE PMQLNFFLSN
       490        500        510        520        530        540
PVEQVSCGDN HVVVLTRNKE VYSWGCGEYG RLGLDSEEDY YTPQKVDVPK ALIIVAVQCG
       550        560        570        580        590        600
CDGTFLLTQS GKVLACGLNE FNKLGLNQCM SGIINHEAYH EVPYTTSFTL AKQLSFYKIR
       610        620        630        640        650        660
TIAPGKTHTA AIDERGRLLT FGCNKCGQLG VGNYKKRLGI NLLGGPLGGK QVIRVSCGDE
       670        680        690        700        710        720
FTIAATDDNH IFAWGNGGNG RLAMTPTERP HGSDICTSWP RPIFGSLHHV PDLSCRGWHT
       730        740        750        760        770        780
ILIVEKVLNS KTIRSNSSGL SIGTVFQSSS PGGGGGGGGG EEEDSQQESE TPDPSGGFRG
       790        800        810        820        830        840
TMEADRGMEG LISPTEAMGN SNGASSSCPG WLRKELENAE FIPMPDSPSP LSAAFSESEK
       850        860        870        880        890        900
DTLPYEELQG LKVASEAPLE HKPQVEASSP RLNPAVTCAG KGTPLTPPAC ACSSLQVEVE
       910        920        930        940        950        960
RLQGLVLKCL AEQQKLQQEN LQIFTQLQKL NKKLEGGQQV GMHSKGTQTA KEEMEMDPKP
       970
DLDSDSWCLL GTDSCRPSL

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TD19-2-unknown	MSVLGE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TD19-2-Acetylation	SVLGEY...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TD19-2-Acetylation	SVLGEY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TD19-2-Acetylation	SVLGEY...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q8TD19-2-Acetylation	SVLGEY...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8TD19-18-unknown	FGSESG...	18		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12922
Q8TD19-119-unknown	MDNTTL...	119		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450943
Q8TD19-119-unknown	MDNTTL...	119		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452537
Q8TD19-832-	SAAFSE...	832			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TD19-832-	SAAFSE...	832			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TD19-832-	SAAFSE...	832			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8TD19-832-unknown	SAAFSE...	832		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14779
Q8TD19-833-	AAFSES...	833			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8TD19-833-	AAFSES...	833			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TD19-833-	AAFSES...	833			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TD19-833-	AAFSES...	833			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q8TD19-833-	AAFSES...	833			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8TD19-834-	AFSESE...	834			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8TD19-834-	AFSESE...	834			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8TD19-834-	AFSESE...	834			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TD19-834-	AFSESE...	834			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SINSDF	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12922
...ANLIKL	191	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452537
...FELLTL	246	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450943
...SPSPLS	831	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14779
...CRPSL	979	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	17	NSDF.\|.FGSE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	831	SPLS.\|.SAAF	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)