Q92522: Histone H1x

General Information

Protein names	- Histone H1x
Gene names	H1FX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92522

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVELEEALP VTTAEGMAKK VTKAGGSAAL SPSKKRKNSK KKNQPGKYSQ LVVETIRRLG
        70         80         90        100        110        120
ERNGSSLAKI YTEAKKVPWF DQQNGRTYLK YSIKALVQND TLLQVKGTGA NGSFKLNRKK
       130        140        150        160        170        180
LEGGGERRGA PAAATAPAPT AHKAKKAAPG AAGSRRADKK PARGQKPEQR SHKKGAGAKK
       190        200        210
DKGGKAKKTA AAGGKKVKKA AKPSVPKVPK GRK

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92522-2-unknown	MSVELE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92522-2-unknown	MSVELE...	1			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92522-2-unknown	MSVELE...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92522-2-Acetylation	SVELEE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92522-2-Acetylation	SVELEE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92522-2-	SVELEE...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92522-23-unknown	KAGGSA...	23		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14798
Q92522-101-unknown	TLLQVK...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12991
Q92522-129-	GAPAAA...	129			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92522-129-unknown	GAPAAA...	129			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92522-141-unknown	AHKAKK...	141		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14799
Q92522-147-	AAPGAA...	147			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AKKVTK	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14798
...LVQNDT	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12991
...APAPTA	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14799
...PKGRK	213	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	22	KVTK.\|.KAGG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	100	QNDT.\|.TLLQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	140	APTA.\|.AHKA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)