Q96D71: RalBP1-associated Eps domain-containing protein 1

General Information

Protein names	- RalBP1-associated Eps domain-containing protein 1 - RalBP1-interacting protein 1
Gene names	REPS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96D71

21 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RalBP1-associated Eps domain-containing protein 1 - Isoform 3 of RalBP1-associated Eps domain-containing protein 1 - Isoform 4 of RalBP1-associated Eps domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MEGLTLSDAE QKYYSDLFSY CDIESTKKVV VNGRVLELFR AAQLPNDVVL QIMELCGATR
        70         80         90        100        110        120
LGYFGRSQFY IALKLVAVAQ SGFPLRVESI NTVKDLPLPR FVASKNEQES RHAASYSSDS
       130        140        150        160        170        180
ENQGSYSGVI PPPPGRGQVK KGSVSHDTVQ PRTSADAQEP ASPVVSPQQS PPTSPHTWRK
       190        200        210        220        230        240
HSRHPSGGNS ERPLAGPGPF WSPFGEAQSG SSAGDAVWSG HSPPPPQENW VSFADTPPTS
       250        260        270        280        290        300
TLLTMHPASV QDQTTVRTVA SATTAIEIRR QSSSYDDPWK ITDEQRQYYV NQFKTIQPDL
       310        320        330        340        350        360
NGFIPGSAAK EFFTKSKLPI LELSHIWELS DFDKDGALTL DEFCAAFHLV VARKNGYDLP
       370        380        390        400        410        420
EKLPESLMPK LIDLEDSADV GDQPGEVGYS GSPAEAPPSK SPSMPSLNQT WPELNQSSEQ
       430        440        450        460        470        480
WETFSERSSS SQTLTQFDSN IAPADPDTAI VHPVPIRMTP SKIHMQEMEL KRTGSDHTNP
       490        500        510        520        530        540
TSPLLVKPSD LLEENKINSS VKFASGNTVA DGYSSSDSFT SDPEQIGSNV TRQRSHSGTS
       550        560        570        580        590        600
PDNTAPPPPP PRPQPSHSRS SSLDMNRTFT VTTGQQQAGV VAHPPAVPPR PQPSQAPGPA
       610        620        630        640        650        660
VHRPVDADGL ITHTSTSPQQ IPEQPNFADF SQFEVFAASN VNDEQDDEAE KHPEVLPAEK
       670        680        690        700        710        720
ASDPASSLRV AKTDSKTEEK TAASAPANVS KGTTPLAPPP KPVRRRLKSE DELRPEVDEH
       730        740        750        760        770        780
TQKTGVLAAV LASQPSIPRS VGKDKKAIQA SIRRNKETNT VLARLNSELQ QQLKDVLEER
       790
ISLEVQLEQL RPFSHL         10         20         30         40         50         60
MEGLTLSDAE QKYYSDLFSY CDIESTKKVV VNGRVLELFR AAQLPNDVVL QIMELCGATR
        70         80         90        100        110        120
LGYFGRSQFY IALKLVAVAQ SGFPLRVESI NTVKDLPLPR FVASKNEQES RHAASYSSDS
       130        140        150        160        170        180
ENQGSYSGVI PPPPGRGQVK KGSVSHDTVQ PRTSADAQEP ASPVVSPQQS PPTSPHTWRK
       190        200        210        220        230        240
HSRHPSGGNS ERPLAGPGPF WSPFGEAQSG SSAGDAVWSG HSPPPPQENW VSFADTPPTS
       250        260        270        280        290        300
TLLTMHPASV QDQTTVRTVA SATTAIEIRR QSSSYDDPWK ITDEQRQYYV NQFKTIQPDL
       310        320        330        340        350        360
NGFIPGSAAK EFFTKSKLPI LELSHIWELS DFDKDGALTL DEFCAAFHLV VARKNGYDLP
       370        380        390        400        410        420
EKLPESLMPK LIDLEDSADV GDQPGEVGYS GSPAEAPPSK SPSMPSLNQT WPELNQSSEQ
       430        440        450        460        470        480
WETFSERSSS SQTLTQFDSN IAPADPDTAI VHPVPIRMTP SKIHMQEMEL KRTGSDHTNP
       490        500        510        520        530        540
TSPLLVKPSD LLEENKINSS VKFASGNTVA DGYSSSDSFT SDPEQIGSNV TRQRSHSGTS
       550        560        570        580        590        600
PDNTAPPPPP PRPQPSHSRS SSLDMNRTFT VTTGQQQAGV VAHPPAVPPR PQPSQAPGPA
       610        620        630        640        650        660
VHRPVDADGL ITHTSTSPQQ IPEQPNFADF SQFEVFAASN VNDEQDDEAE KHPEVLPAEK
       670        680        690        700        710        720
ASDPASSLRV AKTDSKTEEK TAASAPANVS KGTTPLAPPP KPVRRRLKSE DELRPEVDEH
       730        740        750        760        770        780
TQKTGVLAAV LASQPSIPRS VGKDKKAIQA SIRRNKETNT VLARLNSELQ QQLKDVLEER
       790
ISLEVQLEQL RPFSHL         10         20         30         40         50         60
MEGLTLSDAE QKYYSDLFSY CDIESTKKVV VNGRVLELFR AAQLPNDVVL QIMELCGATR
        70         80         90        100        110        120
LGYFGRSQFY IALKLVAVAQ SGFPLRVESI NTVKDLPLPR FVASKNEQES RHAASYSSDS
       130        140        150        160        170        180
ENQGSYSGVI PPPPGRGQVK KGSVSHDTVQ PRTSADAQEP ASPVVSPQQS PPTSPHTWRK
       190        200        210        220        230        240
HSRHPSGGNS ERPLAGPGPF WSPFGEAQSG SSAGDAVWSG HSPPPPQENW VSFADTPPTS
       250        260        270        280        290        300
TLLTMHPASV QDQTTVRTVA SATTAIEIRR QSSSYDDPWK ITDEQRQYYV NQFKTIQPDL
       310        320        330        340        350        360
NGFIPGSAAK EFFTKSKLPI LELSHIWELS DFDKDGALTL DEFCAAFHLV VARKNGYDLP
       370        380        390        400        410        420
EKLPESLMPK LIDLEDSADV GDQPGEVGYS GSPAEAPPSK SPSMPSLNQT WPELNQSSEQ
       430        440        450        460        470        480
WETFSERSSS SQTLTQFDSN IAPADPDTAI VHPVPIRMTP SKIHMQEMEL KRTGSDHTNP
       490        500        510        520        530        540
TSPLLVKPSD LLEENKINSS VKFASGNTVA DGYSSSDSFT SDPEQIGSNV TRQRSHSGTS
       550        560        570        580        590        600
PDNTAPPPPP PRPQPSHSRS SSLDMNRTFT VTTGQQQAGV VAHPPAVPPR PQPSQAPGPA
       610        620        630        640        650        660
VHRPVDADGL ITHTSTSPQQ IPEQPNFADF SQFEVFAASN VNDEQDDEAE KHPEVLPAEK
       670        680        690        700        710        720
ASDPASSLRV AKTDSKTEEK TAASAPANVS KGTTPLAPPP KPVRRRLKSE DELRPEVDEH
       730        740        750        760        770        780
TQKTGVLAAV LASQPSIPRS VGKDKKAIQA SIRRNKETNT VLARLNSELQ QQLKDVLEER
       790
ISLEVQLEQL RPFSHL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

21 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96D71-1-unknown	MEGLTL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96D71-1-unknown	MEGLTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87286
Q96D71-1-unknown	MEGLTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87287
Q96D71-1-unknown	MEGLTL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87288
Q96D71-15-unknown	SDLFSY...	15	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434251
Q96D71-15-unknown	SDLFSY...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195046
Q96D71-15-unknown	SDLFSY...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195047
Q96D71-15-unknown	SDLFSY...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt195048
Q96D71-239-	TSTLLT...	239		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96D71-239-unknown	TSTLLT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165560
Q96D71-239-unknown	TSTLLT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165561
Q96D71-239-unknown	TSTLLT...	239	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165562
Q96D71-245-unknown	MHPASV...	245	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177784
Q96D71-245-unknown	MHPASV...	245	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177785
Q96D71-245-unknown	MHPASV...	245	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177786
Q96D71-245-	MHPASV...	245		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96D71-391-unknown	GSPAEA...	391	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165309
Q96D71-391-unknown	GSPAEA...	391	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165310
Q96D71-391-unknown	GSPAEA...	391	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165311
Q96D71-391-	GSPAEA...	391		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96D71-391-	GSPAEA...	391		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96D71-439-unknown	SNIAPA...	439	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166744
Q96D71-439-	SNIAPA...	439		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96D71-439-	SNIAPA...	439		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96D71-439-	SNIAPA...	439		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96D71-448-	TAIVHP...	448		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96D71-448-unknown	TAIVHP...	448	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13053
Q96D71-448-unknown	TAIVHP...	448	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172405
Q96D71-448-unknown	TAIVHP...	448	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172406
Q96D71-448-unknown	TAIVHP...	448	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152774
Q96D71-460-unknown	PSKIHM...	460		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96D71-460-unknown	PSKIHM...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161985
Q96D71-460-unknown	PSKIHM...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161987
Q96D71-460-unknown	PSKIHM...	460	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161986
Q96D71-466-unknown	QEMELK...	466		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96D71-466-unknown	QEMELK...	466	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161989
Q96D71-466-unknown	QEMELK...	466	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161991
Q96D71-466-unknown	QEMELK...	466	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161990
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96D71-512-	GYSSSD...	512		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96D71-512-unknown	GYSSSD...	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166741
Q96D71-512-unknown	GYSSSD...	512	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166742
Q96D71-515-	SSDSFT...	515		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96D71-515-unknown	SSDSFT...	515	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170537
Q96D71-515-unknown	SSDSFT...	515	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170538
Q96D71-518-unknown	SFTSDP...	518	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165564
Q96D71-518-unknown	SFTSDP...	518	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165565
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96D71-518-	SFTSDP...	518		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96D71-697-unknown	APPPKP...	697	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8013
Q96D71-697-unknown	APPPKP...	697	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154657
Q96D71-697-unknown	APPPKP...	697	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155545
Q96D71-697-unknown	APPPKP...	697	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155824

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PADPDT	447	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13053
...PADPDT	447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136195
...QQIPEQ	623	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435131
...GTTPLA	696	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8013
...GTTPLA	696	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138082
...GTTPLA	696	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138983
...GTTPLA	696	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139276
...PFSHL	796	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PFSHL	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82904
...PFSHL	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82906
...PFSHL	796	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82905

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	447	DPDT.\|.TAIV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	696	TPLA.\|.APPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)