Q96GM8: Target of EGR1 protein 1

General Information

Protein names	- Target of EGR1 protein 1
Gene names	TOE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96GM8

11 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAADSDDGAV SAPAASDGGV SKSTTSGEEL VVQVPVVDVQ SNNFKEMWPS LLLAIKTANF
        70         80         90        100        110        120
VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSILSL GLACFKRQPD KGEHSYLAQV
       130        140        150        160        170        180
FNLTLLCMEE YVIEPKSVQF LIQHGFNFNQ QYAQGIPYHK GNDKGDESQS QSVRTLFLEL
       190        200        210        220        230        240
IRARRPLVLH NGLIDLVFLY QNFYAHLPES LGTFTADLCE MFPAGIYDTK YAAEFHARFV
       250        260        270        280        290        300
ASYLEYAFRK CERENGKQRA AGSPHLTLEF CNYPSSMRDH IDYRCCLPPA THRPHPTSIC
       310        320        330        340        350        360
DNFSAYGWCP LGPQCPQSHD IDLIIDTDEA AAEDKRRRRR RREKRKRALL NLPGTQTSGE
       370        380        390        400        410        420
AKDGPPKKQV CGDSIKPEET EQEVAADETR NLPHSKQGNK NDLEMGIKAA RPEIADRATS
       430        440        450        460        470        480
EVPGSQASPN PVPGDGLHRA GFDAFMTGYV MAYVEVSQGP QPCSSGPWLP ECHNKVYLSG
       490        500        510
KAVPLTVAKS QFSRSSKAHN QKMKLTWGSS

Isoforms

- Isoform 2 of Target of EGR1 protein 1

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96GM8-2-unknown	MAADSD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96GM8-2-unknown	MAADSD...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96GM8-2-unmodified	AADSDD...	2			other		CNRS/ISV	Large_scale_NTA_Human
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96GM8-2-	AADSDD...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96GM8-2-Acetylation	AADSDD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q96GM8-8-	GAVSAP...	8			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96GM8-8-unknown	GAVSAP...	8			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q96GM8-329-unknown	EAAAED...	329		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13064
Q96GM8-348-	ALLNLP...	348			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96GM8-372-unknown	GDSIKP...	372		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14831
Q96GM8-374-	SIKPEE...	374			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96GM8-374-	SIKPEE...	374			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96GM8-374-	SIKPEE...	374			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96GM8-374-	SIKPEE...	374			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96GM8-374-unknown	SIKPEE...	374		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13065

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IIDTDE	328	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13064
...KKQVCG	371	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14831
...QVCGDS	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13065
...TWGSS	510	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	328	DTDE.\|.EAAA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	371	QVCG.\|.GDSI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	373	CGDS.\|.SIKP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)