Q96PK6: RNA-binding protein 14

General Information

Protein names	- RNA-binding protein 14 - Paraspeckle protein 2 - PSP2 - RNA-binding motif protein 14 - RRM-containing coactivator activator/modulator - Synaptotagmin-interacting protein - SYT-interacting protein
Gene names	RBM14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96PK6

26 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RNA-binding protein 14 - Isoform 3 of RNA-binding protein 14 - Isoform 4 of RNA-binding protein 14 - Isoform 5 of RNA-binding protein 14

Sequence View

        10         20         30         40         50         60
MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGALR AIEALHGHEL
        70         80         90        100        110        120
RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE RRGRVIECDV VKDYAFVHME
       130        140        150        160        170        180
KEADAKAAIA QLNGKEVKGK RINVELSTKG QKKGPGLAVQ SGDKTKKPGA GDTAFPGTGG
       190        200        210        220        230        240
FSATFDYQQA FGNSTGGFDG QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ
       250        260        270        280        290        300
PSVSLGAAYR AQPSASLGVG YRTQPMTAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
       310        320        330        340        350        360
SLGPYGGAQP SASALSSYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA QAASSYGVRA
       370        380        390        400        410        420
AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA SYNAQPSASY NAQSAPYAAQ
       430        440        450        460        470        480
QAASYSSQPA AYVAQPATAA AYASQPAAYA AQATTPMAGS YGAQPVVQTQ LNSYGAQASM
       490        500        510        520        530        540
GLSGSYGAQS AAAATGSYGA AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY
       550        560        570        580        590        600
RGQPGNAYDG AGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
       610        620        630        640        650        660
RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG SYNDYLRAAQ

MHSGYQRRM         10         20         30         40         50         60
MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGALR AIEALHGHEL
        70         80         90        100        110        120
RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE RRGRVIECDV VKDYAFVHME
       130        140        150        160        170        180
KEADAKAAIA QLNGKEVKGK RINVELSTKG QKKGPGLAVQ SGDKTKKPGA GDTAFPGTGG
       190        200        210        220        230        240
FSATFDYQQA FGNSTGGFDG QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ
       250        260        270        280        290        300
PSVSLGAAYR AQPSASLGVG YRTQPMTAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
       310        320        330        340        350        360
SLGPYGGAQP SASALSSYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA QAASSYGVRA
       370        380        390        400        410        420
AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA SYNAQPSASY NAQSAPYAAQ
       430        440        450        460        470        480
QAASYSSQPA AYVAQPATAA AYASQPAAYA AQATTPMAGS YGAQPVVQTQ LNSYGAQASM
       490        500        510        520        530        540
GLSGSYGAQS AAAATGSYGA AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY
       550        560        570        580        590        600
RGQPGNAYDG AGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
       610        620        630        640        650        660
RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG SYNDYLRAAQ

MHSGYQRRM         10         20         30         40         50         60
MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGALR AIEALHGHEL
        70         80         90        100        110        120
RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE RRGRVIECDV VKDYAFVHME
       130        140        150        160        170        180
KEADAKAAIA QLNGKEVKGK RINVELSTKG QKKGPGLAVQ SGDKTKKPGA GDTAFPGTGG
       190        200        210        220        230        240
FSATFDYQQA FGNSTGGFDG QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ
       250        260        270        280        290        300
PSVSLGAAYR AQPSASLGVG YRTQPMTAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
       310        320        330        340        350        360
SLGPYGGAQP SASALSSYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA QAASSYGVRA
       370        380        390        400        410        420
AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA SYNAQPSASY NAQSAPYAAQ
       430        440        450        460        470        480
QAASYSSQPA AYVAQPATAA AYASQPAAYA AQATTPMAGS YGAQPVVQTQ LNSYGAQASM
       490        500        510        520        530        540
GLSGSYGAQS AAAATGSYGA AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY
       550        560        570        580        590        600
RGQPGNAYDG AGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
       610        620        630        640        650        660
RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG SYNDYLRAAQ

MHSGYQRRM         10         20         30         40         50         60
MKIFVGNVDG ADTTPEELAA LFAPYGTVMS CAVMKQFAFV HMRENAGALR AIEALHGHEL
        70         80         90        100        110        120
RPGRALVVEM SRPRPLNTWK IFVGNVSAAC TSQELRSLFE RRGRVIECDV VKDYAFVHME
       130        140        150        160        170        180
KEADAKAAIA QLNGKEVKGK RINVELSTKG QKKGPGLAVQ SGDKTKKPGA GDTAFPGTGG
       190        200        210        220        230        240
FSATFDYQQA FGNSTGGFDG QARQPTPPFF GRDRSPLRRS PPRASYVAPL TAQPATYRAQ
       250        260        270        280        290        300
PSVSLGAAYR AQPSASLGVG YRTQPMTAQA ASYRAQPSVS LGAPYRGQLA SPSSQSAAAS
       310        320        330        340        350        360
SLGPYGGAQP SASALSSYGG QAAAASSLNS YGAQGSSLAS YGNQPSSYGA QAASSYGVRA
       370        380        390        400        410        420
AASSYNTQGA ASSLGSYGAQ AASYGAQSAA SSLAYGAQAA SYNAQPSASY NAQSAPYAAQ
       430        440        450        460        470        480
QAASYSSQPA AYVAQPATAA AYASQPAAYA AQATTPMAGS YGAQPVVQTQ LNSYGAQASM
       490        500        510        520        530        540
GLSGSYGAQS AAAATGSYGA AAAYGAQPSA TLAAPYRTQS SASLAASYAA QQHPQAAASY
       550        560        570        580        590        600
RGQPGNAYDG AGQPSAAYLS MSQGAVANAN STPPPYERTR LSPPRASYDD PYKKAVAMSK
       610        620        630        640        650        660
RYGSDRRLAE LSDYRRLSES QLSFRRSPTK SSLDYRRLPD AHSDYARYSG SYNDYLRAAQ

MHSGYQRRM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96PK6-1-unknown	MKIFVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96PK6-1-unknown	MKIFVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87086
Q96PK6-1-unknown	MKIFVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87087
Q96PK6-1-unknown	MKIFVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87088
Q96PK6-1-unknown	MKIFVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87089
Q96PK6-51-unknown	AIEALH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172028
Q96PK6-51-unknown	AIEALH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172029
Q96PK6-51-unknown	AIEALH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172030
Q96PK6-51-unknown	AIEALH...	51	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172031
Q96PK6-51-	AIEALH...	51		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-192-	GNSTGG...	192		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-194-	STGGFD...	194		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-232-	AQPATY...	232		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-247-	AAYRAQ...	247		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-263-unknown	TQPMTA...	263	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10489
Q96PK6-330-	SYGAQG...	330		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-491-	AAAATG...	491		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-492-	AAATGS...	492		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-503-	AYGAQP...	503		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-505-	GAQPSA...	505		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-520-	SSASLA...	520		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-523-	SLAASY...	523		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-525-	AASYAA...	525		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-526-	ASYAAQ...	526		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-526-	ASYAAQ...	526		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-527-	SYAAQQ...	527		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-527-	SYAAQQ...	527		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-529-	AAQQHP...	529		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-529-	AAQQHP...	529		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96PK6-530-	AQQHPQ...	530		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-560-unknown	SMSQGA...	560	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14851
Q96PK6-560-	SMSQGA...	560		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-562-	SQGAVA...	562		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-562-	SQGAVA...	562		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-562-	SQGAVA...	562		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96PK6-562-	SQGAVA...	562		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96PK6-565-	AVANAN...	565		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q96PK6-565-	AVANAN...	565		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-565-	AVANAN...	565		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q96PK6-565-	AVANAN...	565		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q96PK6-568-	NANSTP...	568		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q96PK6-571-	STPPPY...	571		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVGYRT	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10489
...SAAYLS	559	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14851
...YQRRM	669	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	262	GYRT.\|.TQPM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	559	AYLS.\|.SMSQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)