Q99613: Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit C {ECO:0000255\|HAMAP-Rule:MF_03002} - eIF3c {ECO:0000255\|HAMAP-Rule:MF_03002} - Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255\|HAMAP-Rule:MF_03002} - eIF3 p110 {ECO:0000255\|HAMAP-Rule:MF_03002}
Gene names	EIF3C
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99613

9 N-termini

9 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL
        70         80         90        100        110        120
TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEL
       130        140        150        160        170        180
WEDKEGKKKM NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG
       190        200        210        220        230        240
SSDEDEDEDG VSAATFLKKK SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS
       250        260        270        280        290        300
DSEEEEGKQT ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEDNEGGE
       310        320        330        340        350        360
WERVRGGVPL VKEKPKMFAK GTEITHAVVI KKLNEILQAR GKKGTDRAAQ IELLQLLVQI
       370        380        390        400        410        420
AAENNLGEGV IVKIKFNIIA SLYDYNPNLA TYMKPEMWGK CLDCINELMD ILFANPNIFV
       430        440        450        460        470        480
GENILEESEN LHNADQPLRV RGCILTLVER MDEEFTKIMQ NTDPHSQEYV EHLKDEAQVC
       490        500        510        520        530        540
AIIERVQRYL EEKGTTEEVC RIYLLRILHT YYKFDYKAHQ RQLTPPEGSS KSEQDQAENE
       550        560        570        580        590        600
GEDSAVLMER LCKYIYAKDR TDRIRTCAIL CHIYHHALHS RWYQARDLML MSHLQDNIQH
       610        620        630        640        650        660
ADPPVQILYN RTMVQLGICA FRQGLTKDAH NALLDIQSSG RAKELLGQGL LLRSLQERNQ
       670        680        690        700        710        720
EQEKVERRRQ VPFHLHINLE LLECVYLVSA MLLEIPYMAA HESDARRRMI SKQFHHQLRV
       730        740        750        760        770        780
GERQPLLGPP ESMREHVVAA SKAMKMGDWK TCHSFIINEK MNGKVWDLFP EADKVRTMLV
       790        800        810        820        830        840
RKIQEESLRT YLFTYSSVYD SISMETLSDM FELDLPTVHS IISKMIINEE LMASLDQPTQ
       850        860        870        880        890        900
TVVMHRTEPT AQQNLALQLA EKLGSLVENN ERVFDHKQGT YGGYFRDQKD GYRKNEGYMR
       910
RGGYRQQQSQ TAY

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 3 subunit C

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99613-1-unknown	MSRFFT...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99613-36-unknown	LLLSED...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10494
Q99613-37-unknown	LLSEDE...	37	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14894
Q99613-71-unknown	MKIRDV...	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457389
Q99613-71-unknown	MKIRDV...	71	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455277
Q99613-190-	GVSAAT...	190		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99613-195-unknown	TFLKKK...	195	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13140
Q99613-306-	GGVPLV...	306		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q99613-427-unknown	ESENLH...	427	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8043
Q99613-461-unknown	NTDPHS...	461	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8044

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YGKQPL	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10494
...GKQPLL	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14894
...KIRKYN	148	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455278
...IRKYNR	149	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457389
...GVSAAT	194	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13140
...KKKSEA	202	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455277
...ENILEE	426	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8043
...TKIMQN	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8044
...SQTAY	913	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	35	KQPL.\|.LLLS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	36	QPLL.\|.LLSE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	194	SAAT.\|.TFLK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATS_HUMAN	426	ILEE.\|.ESEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	460	IMQN.\|.NTDP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)