Q9H501: ESF1 homolog

General Information

Protein names	- ESF1 homolog - ABT1-associated protein
Gene names	ESF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H501

9 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSKQEIMSD QRFRRVAKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN YAVDKRGRPI
        70         80         90        100        110        120
SHSTTEDLKR FYDLSDSDSN LSGEDSKALS QKKIKKKKTQ TKKEIDSKNL VEKKKETKKA
       130        140        150        160        170        180
NHKGSENKTD LDNSIGIKKM KTSCKFKIDS NISPKKDSKE FTQKNKKEKK NIVQHTTDSS
       190        200        210        220        230        240
LEEKQRTLDS GTSEIVKSPR IECSKTRREM QSVVQLIMTR DSDGYENSTD GEMCDKDALE
       250        260        270        280        290        300
EDSESVSEIG SDEESENEIT SVGRASGDDD GSEDDEEEDE DEEEDEDEDS EDDDKSDSGP
       310        320        330        340        350        360
DLARGKGNIE TSSEDEDDTA DLFPEESGFE HAWRELDKDA PRADEITRRL AVCNMDWDRL
       370        380        390        400        410        420
KAKDLLALFN SFKPKGGVIF SVKIYPSEFG KERMKEEQVQ GPVELLSIPE DAPEKDWTSR
       430        440        450        460        470        480
EKLRDYQFKR LKYYYAVVDC DSPETASKIY EDCDGLEFES SCSFIDLRFI PDDITFDDEP
       490        500        510        520        530        540
KDVASEVNLT AYKPKYFTSA AMGTSTVEIT WDETDHERIT MLNRKFKKEE LLDMDFQAYL
       550        560        570        580        590        600
ASSSEDEEEI EEELQGDDGV NVEEDGKTKK SQKDDEEQIA KYRQLLQVIQ EKEKKGKEND
       610        620        630        640        650        660
MEMEIKWVPG LKESAEEMVK NKLEGKDKLT PWEQFLEKKK EKKRLKRKQK ALAEEASEEE
       670        680        690        700        710        720
LPSDVDLNDP YFAEEVKQIG INKKSVKSAK DGTSPEEEIE IERQKAEMAL LMMDEDEDSK
       730        740        750        760        770        780
KHFNYNKIVE HQNLSKKKKK QLMKKKELIE DDFEVNVNDA RFQAMYTSHL FNLDPSDPNF
       790        800        810        820        830        840
KKTKAMEKIL EEKARQRERK EQELTQAIKK KESEIEKESQ RKSIDPALSM LIKSIKTKTE
       850
QFQARKKQKV K

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H501-2-unknown	MSSKQE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H501-2-Acetylation	SSKQEI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H501-2-Acetylation	SSKQEI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H501-2-Acetylation	SSKQEI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H501-48-unknown	KLNYAV...	48			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H501-48-	KLNYAV...	48			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9H501-171-	NIVQHT...	171			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H501-536-unknown	FQAYLA...	536		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13312
Q9H501-688-	SAKDGT...	688			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H501-692-	GTSPEE...	692			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H501-692-	GTSPEE...	692			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9H501-744-unknown	KKKELI...	744		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14999

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLDMDF	535	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13312
...KKQLMK	743	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14999
...KQKVK	851		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KQKVK	851		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KQKVK	851	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KQKVK	851		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KQKVK	851		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	535	DMDF.\|.FQAY	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	743	QLMK.\|.KKKE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)