Q9HAW4: Claspin

General Information

Protein names	- Claspin - hClaspin
Gene names	CLSPN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9HAW4

8 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Claspin - Isoform 3 of Claspin

Sequence View

        10         20         30         40         50         60
MTGEVGSEVH LEINDPNVIS QEEADSPSDS GQGSYETIGP LSEGDSDEEI FVSKKLKNRK
        70         80         90        100        110        120
VLQDSDSETE DTNASPEKTT YDSAEEENKE NLYAGKNTKI KRIYKTVADS DESYMEKSLY
       130        140        150        160        170        180
QENLEAQVKP CLELSLQSGN STDFTTDRKS SKKHIHDKEG TAGKAKVKSK RRLEKEERKM
       190        200        210        220        230        240
EKIRQLKKKE TKNQEDDVEQ PFNDSGCLLV DKDLFETGLE DENNSPLEDE ESLESIRAAV
       250        260        270        280        290        300
KNKVKKHKKK EPSLESGVHS FEEGSELSKG TTRKERKAAR LSKEALKQLH SETQRLIRES
       310        320        330        340        350        360
ALNLPYHMPE NKTIHDFFKR KPRPTCHGNA MALLKSSKYQ SSHHKEIIDT ANTTEMNSDH
       370        380        390        400        410        420
HSKGSEQTTG AENEVETNAL PVVSKETQII TGSDESCRKD LVKNEELEIQ EKQKQSDIRP
       430        440        450        460        470        480
SPGDSSVLQQ ESNFLGNNHS EECQVGGLVA FEPHALEGEG PQNPEETDEK VEEPEQQNKS
       490        500        510        520        530        540
SAVGPPEKVR RFTLDRLKQL GVDVSIKPRL GADEDSFVIL EPETNRELEA LKQRFWKHAN
       550        560        570        580        590        600
PAAKPRAGQT VNVNVIVKDM GTDGKEELKA DVVPVTLAPK KLDGASHTKP GEKLQVLKAK
       610        620        630        640        650        660
LQEAMKLRRF EERQKRQALF KLDNEDGFEE EEEEEEEMTD ESEEDGEEKV EKEEKEEELE
       670        680        690        700        710        720
EEEEKEEEEE EEGNQETAEF LLSSEEIETK DEKEMDKENN DGSSEIGKAV GFLSVPKSLS
       730        740        750        760        770        780
SDSTLLLFKD SSSKMGYFPT EEKSETDENS GKQPSKLDED DSCSLLTKES SHNSSFELIG
       790        800        810        820        830        840
STIPSYQPCN RQTGRGTSFF PTAGGFRSPS PGLFRASLVS SASKSSGKLS EPSLPIEDSQ
       850        860        870        880        890        900
DLYNASPEPK TLFLGAGDFQ FCLEDDTQSQ LLDADGFLNV RNHRNQYQAL KPRLPLASMD
       910        920        930        940        950        960
ENAMDANMDE LLDLCTGKFT SQAEKHLPRK SDKKENMEEL LNLCSGKFTS QDASTPASSE
       970        980        990       1000       1010       1020
LNKQEKESSM GDPMEEALAL CSGSFPTDKE EEDEEEEFGD FRLVSNDNEF DSDEDEHSDS
      1030       1040       1050       1060       1070       1080
GNDLALEDHE DDDEEELLKR SEKLKRQMRL RKYLEDEAEV SGSDVGSEDE YDGEEIDEYE
      1090       1100       1110       1120       1130       1140
EDVIDEVLPS DEELQSQIKK IHMKTMLDDD KRQLRLYQER YLADGDLHSD GPGRMRKFRW
      1150       1160       1170       1180       1190       1200
KNIDDASQMD LFHRDSDDDQ TEEQLDESEA RWRKERIERE QWLRDMAQQG KITAEEEEEI
      1210       1220       1230       1240       1250       1260
GEDSQFMILA KKVTAKALQK NASRPMVIQE SKSLLRNPFE AIRPGSAQQV KTGSLLNQPK
      1270       1280       1290       1300       1310       1320
AVLQKLAALS DHNPSAPRNS RNFVFHTLSP VKAEAAKESS KSQVKKRGPS FMTSPSPKHL
      1330
KTDDSTSGLT RSIFKYLES         10         20         30         40         50         60
MTGEVGSEVH LEINDPNVIS QEEADSPSDS GQGSYETIGP LSEGDSDEEI FVSKKLKNRK
        70         80         90        100        110        120
VLQDSDSETE DTNASPEKTT YDSAEEENKE NLYAGKNTKI KRIYKTVADS DESYMEKSLY
       130        140        150        160        170        180
QENLEAQVKP CLELSLQSGN STDFTTDRKS SKKHIHDKEG TAGKAKVKSK RRLEKEERKM
       190        200        210        220        230        240
EKIRQLKKKE TKNQEDDVEQ PFNDSGCLLV DKDLFETGLE DENNSPLEDE ESLESIRAAV
       250        260        270        280        290        300
KNKVKKHKKK EPSLESGVHS FEEGSELSKG TTRKERKAAR LSKEALKQLH SETQRLIRES
       310        320        330        340        350        360
ALNLPYHMPE NKTIHDFFKR KPRPTCHGNA MALLKSSKYQ SSHHKEIIDT ANTTEMNSDH
       370        380        390        400        410        420
HSKGSEQTTG AENEVETNAL PVVSKETQII TGSDESCRKD LVKNEELEIQ EKQKQSDIRP
       430        440        450        460        470        480
SPGDSSVLQQ ESNFLGNNHS EECQVGGLVA FEPHALEGEG PQNPEETDEK VEEPEQQNKS
       490        500        510        520        530        540
SAVGPPEKVR RFTLDRLKQL GVDVSIKPRL GADEDSFVIL EPETNRELEA LKQRFWKHAN
       550        560        570        580        590        600
PAAKPRAGQT VNVNVIVKDM GTDGKEELKA DVVPVTLAPK KLDGASHTKP GEKLQVLKAK
       610        620        630        640        650        660
LQEAMKLRRF EERQKRQALF KLDNEDGFEE EEEEEEEMTD ESEEDGEEKV EKEEKEEELE
       670        680        690        700        710        720
EEEEKEEEEE EEGNQETAEF LLSSEEIETK DEKEMDKENN DGSSEIGKAV GFLSVPKSLS
       730        740        750        760        770        780
SDSTLLLFKD SSSKMGYFPT EEKSETDENS GKQPSKLDED DSCSLLTKES SHNSSFELIG
       790        800        810        820        830        840
STIPSYQPCN RQTGRGTSFF PTAGGFRSPS PGLFRASLVS SASKSSGKLS EPSLPIEDSQ
       850        860        870        880        890        900
DLYNASPEPK TLFLGAGDFQ FCLEDDTQSQ LLDADGFLNV RNHRNQYQAL KPRLPLASMD
       910        920        930        940        950        960
ENAMDANMDE LLDLCTGKFT SQAEKHLPRK SDKKENMEEL LNLCSGKFTS QDASTPASSE
       970        980        990       1000       1010       1020
LNKQEKESSM GDPMEEALAL CSGSFPTDKE EEDEEEEFGD FRLVSNDNEF DSDEDEHSDS
      1030       1040       1050       1060       1070       1080
GNDLALEDHE DDDEEELLKR SEKLKRQMRL RKYLEDEAEV SGSDVGSEDE YDGEEIDEYE
      1090       1100       1110       1120       1130       1140
EDVIDEVLPS DEELQSQIKK IHMKTMLDDD KRQLRLYQER YLADGDLHSD GPGRMRKFRW
      1150       1160       1170       1180       1190       1200
KNIDDASQMD LFHRDSDDDQ TEEQLDESEA RWRKERIERE QWLRDMAQQG KITAEEEEEI
      1210       1220       1230       1240       1250       1260
GEDSQFMILA KKVTAKALQK NASRPMVIQE SKSLLRNPFE AIRPGSAQQV KTGSLLNQPK
      1270       1280       1290       1300       1310       1320
AVLQKLAALS DHNPSAPRNS RNFVFHTLSP VKAEAAKESS KSQVKKRGPS FMTSPSPKHL
      1330
KTDDSTSGLT RSIFKYLES

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9HAW4-1-unknown	MTGEVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9HAW4-1-unknown	MTGEVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71024
Q9HAW4-1-unknown	MTGEVG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71025
Q9HAW4-26-unknown	SPSDSG...	26	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2326
Q9HAW4-26-unknown	SPSDSG...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137244
Q9HAW4-26-unknown	SPSDSG...	26	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137246
Q9HAW4-214-unknown	LFETGL...	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13356
Q9HAW4-214-unknown	LFETGL...	214	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147124
Q9HAW4-214-unknown	LFETGL...	214	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147125
Q9HAW4-564-	GKEELK...	564		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9HAW4-564-unknown	GKEELK...	564	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172415
Q9HAW4-984-	SFPTDK...	984		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9HAW4-984-unknown	SFPTDK...	984	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177003
Q9HAW4-984-unknown	SFPTDK...	984	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177002
Q9HAW4-1073-unknown	GEEIDE...	1073	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2978
Q9HAW4-1073-unknown	GEEIDE...	1073	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157168
Q9HAW4-1073-unknown	GEEIDE...	1073	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157311

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QEEADS	25	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2326
...QEEADS	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120163
...QEEADS	25	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt120166
...LVDKDL	213	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13356
...LVDKDL	213	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130458
...LVDKDL	213	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130459
...EDEYDG	1072	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2978
...EDEYDG	1072	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140669
...EDEYDG	1072	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140810
...KYLES	1339		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KYLES	1339		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KYLES	1339	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KYLES	1339	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66642
...KYLES	1339		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KYLES	1339		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	25	EADS.\|.SPSD	inferred from experiment	unknown	MEROPS	Freire R	Semple JI et al.:Cleavage and degradation of Cla... (C14.003)	17431426,
GRAB_HUMAN	213	DKDL.\|.LFET	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP7_HUMAN	1072	EYDG.\|.GEEI	inferred from experiment	unknown	MEROPS	Clarke PR	Clarke CA et al.:Cleavage of claspin by caspase-... (C14.004)	16123041,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)