Q9UKY7: Protein CDV3 homolog

General Information

Protein names	- Protein CDV3 homolog
Gene names	CDV3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UKY7

25 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein CDV3 homolog - Isoform 3 of Protein CDV3 homolog

Sequence View

        10         20         30         40         50         60
MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG GAGAGTRPGD
        70         80         90        100        110        120
GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV QAMQISSEKE EDDNEKRQDP
       130        140        150        160        170        180
GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP PAPVIVTETP EPAMTSGVYR PPGARLTTTR
       190        200        210        220        230        240
KTPQGPPEIY SDTQFPSLQS TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL
       250
DNQYAVLENQ KSSHSQYN         10         20         30         40         50         60
MAETEERSLD NFFAKRDKKK KKERSNRAAS AAGAAGSAGG SSGAAGAAGG GAGAGTRPGD
        70         80         90        100        110        120
GGTASAGAAG PGAATKAVTK DEDEWKELEQ KEVDYSGLRV QAMQISSEKE EDDNEKRQDP
       130        140        150        160        170        180
GDNWEEGGGG GGGMEKSSGP WNKTAPVQAP PAPVIVTETP EPAMTSGVYR PPGARLTTTR
       190        200        210        220        230        240
KTPQGPPEIY SDTQFPSLQS TAKHVESRKD KEMEKSFEVV RHKNRGRDEV SKNQALKLQL
       250
DNQYAVLENQ KSSHSQYN

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

25 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UKY7-1-unknown	MAETEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70152
Q9UKY7-2-unknown	MAETEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKY7-2-Acetylation	AETEER...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKY7-2-Acetylation	AETEER...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111720
Q9UKY7-37-unknown	SAGGSS...	37		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4289
Q9UKY7-37-unknown	SAGGSS...	37		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138140
Q9UKY7-65-unknown	SAGAAG...	65		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174926
Q9UKY7-65-	SAGAAG...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UKY7-77-	AVTKDE...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UKY7-77-	AVTKDE...	77			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UKY7-77-	AVTKDE...	77			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UKY7-77-unknown	AVTKDE...	77		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173095
Q9UKY7-100-unknown	VQAMQI...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166851
Q9UKY7-100-	VQAMQI...	100			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UKY7-100-	VQAMQI...	100			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9UKY7-102-	AMQISS...	102			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UKY7-102-unknown	AMQISS...	102		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164173
Q9UKY7-103-unknown	MQISSE...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70153
Q9UKY7-103-unknown	MQISSE...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96293
Q9UKY7-103-	MQISSE...	103			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9UKY7-104-	QISSEK...	104			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UKY7-104-	QISSEK...	104			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UKY7-104-	QISSEK...	104			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UKY7-104-unknown	QISSEK...	104		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15113
Q9UKY7-104-unknown	QISSEK...	104		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164178
Q9UKY7-104-unknown	QISSEK...	104		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142581
Q9UKY7-107-	SEKEED...	107			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UKY7-107-unknown	SEKEED...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176673
Q9UKY7-107-unknown	SEKEED...	107		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176674
Q9UKY7-123-	NWEEGG...	123			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UKY7-123-	NWEEGG...	123			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UKY7-123-unknown	NWEEGG...	123		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170390
Q9UKY7-123-unknown	NWEEGG...	123		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt170391
Q9UKY7-181-unknown	KTPQGP...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164175
Q9UKY7-181-unknown	KTPQGP...	181		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164176
Q9UKY7-181-	KTPQGP...	181			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9UKY7-181-	KTPQGP...	181			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9UKY7-181-	KTPQGP...	181			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UKY7-191-unknown	SDTQFP...	191			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UKY7-191-unknown	SDTQFP...	191		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UKY7-191-unknown	SDTQFP...	191		inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9UKY7-191-	SDTQFP...	191			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UKY7-200-	STAKHV...	200			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9UKY7-200-	STAKHV...	200			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AGAAGS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4289
...AGAAGS	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121165
...RVQAMQ	103	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15113
...RVQAMQ	103	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125775
...HSQYN	258	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	36	AAGS.\|.SAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	103	QAMQ.\|.QISS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)