Q9ULX6: A-kinase anchor protein 8-like
Protein names | - A-kinase anchor protein 8-like - AKAP8-like protein - Helicase A-binding protein 95 - HAP95 - Homologous to AKAP95 protein - HA95 - Neighbor of A-kinase-anchoring protein 95 - Neighbor of AKAP95 |
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Gene names | AKAP8L |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9ULX6 |
8
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG YGQDNTTNYG
70 80 90 100 110 120
YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD MVPHLETDMM QGGVYGSGGE
130 140 150 160 170 180
RYDSYESCDS RAVLSERDLY RSGYDYSELD PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA
190 200 210 220 230 240
QGWARDARSG RPMASGYGRM WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG
250 260 270 280 290 300
AFPGGSRFGF GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS
310 320 330 340 350 360
DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG ALTTQDENGQ
370 380 390 400 410 420
TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY EDEMASHLDS KFHKEHFKYV
430 440 450 460 470 480
GTKLPKQTAD FLQEYVTNKT KKTEELRKTV EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE
490 500 510 520 530 540
AAHCAACDLF IPMQFGIIQK HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE
550 560 570 580 590 600
RYLKGENPFT DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV
610 620 630 640
SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP
Isoforms
- Isoform 2 of A-kinase anchor protein 8-like - Isoform 2 of A-kinase anchor protein 8-likeSequence View
10 20 30 40 50 60
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG YGQDNTTNYG
70 80 90 100 110 120
YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD MVPHLETDMM QGGVYGSGGE
130 140 150 160 170 180
RYDSYESCDS RAVLSERDLY RSGYDYSELD PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA
190 200 210 220 230 240
QGWARDARSG RPMASGYGRM WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG
250 260 270 280 290 300
AFPGGSRFGF GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS
310 320 330 340 350 360
DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG ALTTQDENGQ
370 380 390 400 410 420
TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY EDEMASHLDS KFHKEHFKYV
430 440 450 460 470 480
GTKLPKQTAD FLQEYVTNKT KKTEELRKTV EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE
490 500 510 520 530 540
AAHCAACDLF IPMQFGIIQK HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE
550 560 570 580 590 600
RYLKGENPFT DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV
610 620 630 640
SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP
10 20 30 40 50 60
MSYTGFVQGS ETTLQSTYSD TSAQPTCDYG YGTWNSGTNR GYEGYGYGYG YGQDNTTNYG
70 80 90 100 110 120
YGMATSHSWE MPSSDTNANT SASGSASADS VLSRINQRLD MVPHLETDMM QGGVYGSGGE
130 140 150 160 170 180
RYDSYESCDS RAVLSERDLY RSGYDYSELD PEMEMAYEGQ YDAYRDQFRM RGNDTFGPRA
190 200 210 220 230 240
QGWARDARSG RPMASGYGRM WEDPMGARGQ CMSGASRLPS LFSQNIIPEY GMFQGMRGGG
250 260 270 280 290 300
AFPGGSRFGF GFGNGMKQMR RTWKTWTTAD FRTKKKKRKQ GGSPDEPDSK ATRTDCSDNS
310 320 330 340 350 360
DSDNDEGTEG EATEGLEGTE AVEKGSRVDG EDEEGKEDGR EEGKEDPEKG ALTTQDENGQ
370 380 390 400 410 420
TKRKLQAGKK SQDKQKKRQR DRMVERIQFV CSLCKYRTFY EDEMASHLDS KFHKEHFKYV
430 440 450 460 470 480
GTKLPKQTAD FLQEYVTNKT KKTEELRKTV EDLDGLIQQI YRDQDLTQEI AMEHFVKKVE
490 500 510 520 530 540
AAHCAACDLF IPMQFGIIQK HLKTMDHNRN RRLMMEQSKK SSLMVARSIL NNKLISKKLE
550 560 570 580 590 600
RYLKGENPFT DSPEEEKEQE EAEGGALDEG AQGEAAGISE GAEGVPAQPP VPPEPAPGAV
610 620 630 640
SPPPPPPPEE EEEGAVPLLG GALQRQIRGI PGLDVEDDEE GGGGAP
Protein Neighborhood
Domains & Features
8 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9ULX6-1-unknown | MSYTGF... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9ULX6-1-unknown | MSYTGF... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt66668 | |||
Q9ULX6-68- | SWEMPS... | 68 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9ULX6-101- | MVPHLE... | 101 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q9ULX6-101- | MVPHLE... | 101 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q9ULX6-101- | MVPHLE... | 101 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q9ULX6-109- | MMQGGV... | 109 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9ULX6-109-unknown | MMQGGV... | 109 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13545 | |||
Q9ULX6-328-unknown | VDGEDE... | 328 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10586 | |||
Q9ULX6-328-unknown | VDGEDE... | 328 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149041 | |||
Q9ULX6-353-unknown | TTQDEN... | 353 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15119 | |||
Q9ULX6-353-unknown | TTQDEN... | 353 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149629 | |||
Q9ULX6-366-unknown | QAGKKS... | 366 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15121 | |||
Q9ULX6-366-unknown | QAGKKS... | 366 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149996 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...HLETDM | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13545 | |||
...EKGSRV | 327 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10586 | |||
...EKGSRV | 327 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt132425 | |||
...EKGALT | 352 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15119 | |||
...EKGALT | 352 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133016 | |||
...TKRKLQ | 365 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15121 | |||
...TKRKLQ | 365 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133388 | |||
...GGGAP | 646 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...GGGAP | 646 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt62286 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 108 | ETDM.|.MMQG | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAA_HUMAN | 327 | GSRV.|.VDGE | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:The substrate specificity profi... (S01.135) | 20536382, |
GRAM_HUMAN | 352 | GALT.|.TTQD | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
GRAM_HUMAN | 365 | RKLQ.|.QAGK | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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