Q9Y265: RuvB-like 1

General Information

Protein names	- RuvB-like 1 - 3.6.4.12 - 49 kDa TATA box-binding protein-interacting protein - 49 kDa TBP-interacting protein - 54 kDa erythrocyte cytosolic protein - ECP-54 - INO80 complex subunit H - Nuclear matrix protein 238 - NMP 238 - Pontin 52 - TIP49a - TIP60-associated protein 54-alpha - TAP54-alpha
Gene names	RUVBL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y265

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG VIVELIKSKK
        70         80         90        100        110        120
MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI
       130        140        150        160        170        180
GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL
       190        200        210        220        230        240
QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL
       250        260        270        280        290        300
HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF
       310        320        330        340        350        360
VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI
       370        380        390        400        410        420
IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK TTLRYSVQLL TPANLLAKIN
       430        440        450
GKDSIEKEHV EEISELFYDA KSSAKILADQ QDKYMK

Isoforms

- Isoform 2 of RuvB-like 1

Sequence View

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Physiological Relevance:

Evidence Codes:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y265-1-unknown,NH2	MKIEEV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9Y265-1-	MKIEEV...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y265-1-unknown	MKIEEV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y265-1-unknown	MKIEEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88442
Q9Y265-1-unknown	MKIEEV...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y265-39-unknown	LVGQEN...	39	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4299
Q9Y265-39-unknown	LVGQEN...	39	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138279
Q9Y265-259-unknown	MMGQLM...	259	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18182
Q9Y265-259-unknown	MMGQLM...	259	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148760

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QAASGL	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4299
...QAASGL	38	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121311
...QDILSM	258	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18182
...QDILSM	258	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132136
...DKYMK	456	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	38	ASGL.\|.LVGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	258	ILSM.\|.MMGQ	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)