Q9Y6I3: Epsin-1
Protein names | - Epsin-1 - EH domain-binding mitotic phosphoprotein - EPS-15-interacting protein 1 |
---|---|
Gene names | EPN1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q9Y6I3 |
8
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI
70 80 90 100 110 120
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG
130 140 150 160 170 180
VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS
190 200 210 220 230 240
SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM
250 260 270 280 290 300
AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP
310 320 330 340 350 360
VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV
370 380 390 400 410 420
SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS
430 440 450 460 470 480
AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA
490 500 510 520 530 540
LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP
550 560 570
VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL
Isoforms
- Isoform 2 of Epsin-1 - Isoform 3 of Epsin-1Sequence View
10 20 30 40 50 60
MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI
70 80 90 100 110 120
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG
130 140 150 160 170 180
VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS
190 200 210 220 230 240
SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM
250 260 270 280 290 300
AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP
310 320 330 340 350 360
VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV
370 380 390 400 410 420
SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS
430 440 450 460 470 480
AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA
490 500 510 520 530 540
LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP
550 560 570
VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL
10 20 30 40 50 60
MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI
70 80 90 100 110 120
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG
130 140 150 160 170 180
VNVREKAKQL VALLRDEDRL REERAHALKT KEKLAQTATA SSAAVGSGPP PEAEQAWPQS
190 200 210 220 230 240
SGEEELQLQL ALAMSKEEAD QPPSCGPEDD AQLQLALSLS REEHDKEERI RRGDDLRLQM
250 260 270 280 290 300
AIEESKRETG GKEESSLMDL ADVFTAPAPA PTTDPWGGPA PMAAAVPTAA PTSDPWGGPP
310 320 330 340 350 360
VPPAADPWGG PAPTPASGDP WRPAAPAGPS VDPWGGTPAP AAGEGPTPDP WGSSDGGVPV
370 380 390 400 410 420
SGPSASDPWT PAPAFSDPWG GSPAKPSTNG TTAAGGFDTE PDEFSDFDRL RTALPTSGSS
430 440 450 460 470 480
AGELELLAGE VPARSPGAFD MSGVRGSLAE AVGSPPPAAT PTPTPPTRKT PESFLGPNAA
490 500 510 520 530 540
LVDLDSLVSR PGPTPPGAKA SNPFLPGGGP ATGPSVTNPF QPAPPATLTL NQLRLSPVPP
550 560 570
VPGAPPTYIS PLGGGPGLPP MMPPGPPAPN TNPFLL
Protein Neighborhood
Domains & Features
8 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9Y6I3-1-unknown | MSTSSL... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9Y6I3-1-unknown | MSTSSL... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt74059 | |||
Q9Y6I3-394-unknown | AGGFDT... | 394 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173685 | |||
Q9Y6I3-394- | AGGFDT... | 394 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9Y6I3-394- | AGGFDT... | 394 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q9Y6I3-394- | AGGFDT... | 394 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q9Y6I3-395-unknown | GGFDTE... | 395 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173682 | |||
Q9Y6I3-395- | GGFDTE... | 395 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q9Y6I3-451-unknown | AVGSPP... | 451 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4306 | |||
Q9Y6I3-451-unknown | AVGSPP... | 451 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152421 | |||
Q9Y6I3-486- | SLVSRP... | 486 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
Q9Y6I3-486-unknown | SLVSRP... | 486 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13660 | |||
Q9Y6I3-486-unknown | SLVSRP... | 486 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152913 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GSLAEA | 450 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4306 | |||
...GSLAEA | 450 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135831 | |||
...LVDLDS | 485 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13660 | |||
...LVDLDS | 485 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136339 | |||
...NPFLL | 576 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...NPFLL | 576 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69677 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATB_HUMAN | 450 | LAEA.|.AVGS | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
GRAB_HUMAN | 485 | DLDS.|.SLVS | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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