O43719: HIV Tat-specific factor 1

General Information

Protein names	- HIV Tat-specific factor 1 - Tat-SF1
Gene names	HTATSF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43719

26 N-termini

8 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF
        70         80         90        100        110        120
PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA
       130        140        150        160        170        180
ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL
       190        200        210        220        230        240
KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL
       250        260        270        280        290        300
SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ
       310        320        330        340        350        360
IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR
       370        380        390        400        410        420
EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM
       430        440        450        460        470        480
AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC
       490        500        510        520        530        540
SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE
       550        560        570        580        590        600
EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS
       610        620        630        640        650        660
EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD
       670        680        690        700        710        720
KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD
       730        740        750
SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

26 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43719-2-unknown	MSGTNL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43719-2-Acetylation	SGTNLD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43719-2-Acetylation	SGTNLD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O43719-2-Acetylation	SGTNLD...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
O43719-2-Acetylation	SGTNLD...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43719-34-unknown	AGGEPD...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10765
O43719-34-	AGGEPD...	34			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-34-	AGGEPD...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43719-34-	AGGEPD...	34			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43719-35-	GGEPDS...	35			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-40-unknown	SLGQQP...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10766
O43719-40-unknown	SLGQQP...	40		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1098
O43719-40-	SLGQQP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O43719-40-	SLGQQP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-40-	SLGQQP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43719-40-	SLGQQP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43719-40-	SLGQQP...	40			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O43719-73-	ANYGFS...	73			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43719-73-	ANYGFS...	73			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-76-	GFSNDG...	76			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43719-76-	GFSNDG...	76			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-76-	GFSNDG...	76			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43719-77-	FSNDGA...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43719-77-	FSNDGA...	77			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-78-	SNDGAS...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43719-78-	SNDGAS...	78			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-78-	SNDGAS...	78			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43719-78-	SNDGAS...	78			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43719-81-unknown	GASSST...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1099
O43719-81-unknown	GASSST...	81			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43719-81-	GASSST...	81			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O43719-81-	GASSST...	81			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-81-	GASSST...	81			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43719-81-	GASSST...	81			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43719-81-	GASSST...	81			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O43719-82-	ASSSTA...	82			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-84-	SSTANV...	84			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-85-	STANVE...	85			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-96-unknown	TAEEPP...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9881
O43719-349-	GTTDYQ...	349			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-349-	GTTDYQ...	349			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43719-413-	AQETAT...	413			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-416-	TATGMA...	416			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-417-	ATGMAF...	417			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-419-	GMAFEE...	419			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-420-	MAFEEP...	420			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-421-unknown	AFEEPI...	421			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O43719-421-	AFEEPI...	421			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O43719-421-	AFEEPI...	421			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43719-421-	AFEEPI...	421			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43719-421-	AFEEPI...	421			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43719-509-unknown	KNDCEE...	509		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13756

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DTQTDA	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10765
...GGEPDS	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10766
...GGEPDS	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1098
...GFSNDG	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1099
...DVHART	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9881
...QLKGEY	223	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412420
...LSMQQK	244	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411381
...KKKTLK	508	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13756
...DDDDI	755	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	33	QTDA.\|.AGGE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	39	EPDS.\|.SLGQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CASP1_HUMAN	39	EPDS.\|.SLGQ	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CASP1_HUMAN	80	SNDG.\|.GASS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAA_HUMAN	95	HART.\|.TAEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	508	KTLK.\|.KNDC	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)