O60231: Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

General Information

Protein names	- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 - 3.6.4.13 - ATP-dependent RNA helicase #3 - DEAH-box protein 16
Gene names	DHX16
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60231

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATPAGLERW VQDELHSVLG LSERHVAQFL IGTAQRCTSA EEFVQRLRDT DTLDLSGPAR
        70         80         90        100        110        120
DFALRLWNKV PRKAVVEKPA RAAEREARAL LEKNRSYRLL EDSEESSEET VSRAGSSLQK
       130        140        150        160        170        180
KRKKRKHLRK KREEEEEEEA SEKGKKKTGG SKQQTEKPES EDEWERTERE RLQDLEERDA
       190        200        210        220        230        240
FAERVRQRDK DRTRNVLERS DKKAYEEAQK RLKMAEEDRK AMVPELRKKS RREYLAKRER
       250        260        270        280        290        300
EKLEDLEAEL ADEEFLFGDV ELSRHERQEL KYKRRVRDLA REYRAAGEQE KLEATNRYHM
       310        320        330        340        350        360
PKETRGQPAR AVDLVEEESG APGEEQRRWE EARLGAASLK FGARDAASQE PKYQLVLEEE
       370        380        390        400        410        420
ETIEFVRATQ LQGDEEPSAP PTSTQAQQKE SIQAVRRSLP VFPFREELLA AIANHQVLII
       430        440        450        460        470        480
EGETGSGKTT QIPQYLFEEG YTNKGMKIAC TQPRRVAAMS VAARVAREMG VKLGNEVGYS
       490        500        510        520        530        540
IRFEDCTSER TVLRYMTDGM LLREFLSEPD LASYSVVMVD EAHERTLHTD ILFGLIKDVA
       550        560        570        580        590        600
RFRPELKVLV ASATMDTARF STFFDDAPVF RIPGRRFPVD IFYTKAPEAD YLEACVVSVL
       610        620        630        640        650        660
QIHVTQPPGD ILVFLTGQEE IEAACEMLQD RCRRLGSKIR ELLVLPIYAN LPSDMQARIF
       670        680        690        700        710        720
QPTPPGARKV VVATNIAETS LTIEGIIYVL DPGFCKQKSY NPRTGMESLT VTPCSKASAN
       730        740        750        760        770        780
QRAGRAGRVA AGKCFRLYTA WAYQHELEET TVPEIQRTSL GNVVLLLKSL GIHDLMHFDF
       790        800        810        820        830        840
LDPPPYETLL LALEQLYALG ALNHLGELTT SGRKMAELPV DPMLSKMILA SEKYSCSEEI
       850        860        870        880        890        900
LTVAAMLSVN NSIFYRPKDK VVHADNARVN FFLPGGDHLV LLNVYTQWAE SGYSSQWCYE
       910        920        930        940        950        960
NFVQFRSMRR ARDVREQLEG LLERVEVGLS SCQGDYIRVR KAITAGYFYH TARLTRSGYR
       970        980        990       1000       1010       1020
TVKQQQTVFI HPNSSLFEQQ PRWLLYHELV LTTKEFMRQV LEIESSWLLE VAPHYYKAKE
      1030       1040
LEDPHAKKMP KKIGKTREEL G

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60231-1-unknown	MATPAG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60231-2-acetylation	ATPAGL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60231-2-acetylation	ATPAGL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60231-114-unknown	AGSSLQ...	114		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9883
O60231-311-	AVDLVE...	311			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60231-311-	AVDLVE...	311			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O60231-319-unknown	SGAPGE...	319		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10806
O60231-356-unknown	VLEEEE...	356		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13759

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ETVSRA	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9883
...LVEEES	318	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10806
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413416
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390319
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000393356
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399101
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411743
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403116
...EPKYQL	354	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000414335
...EPKYQL	354	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13759
...REELG	1041	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	113	VSRA.\|.AGSS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	318	EEES.\|.SGAP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	355	YQLV.\|.VLEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)