O60814: Histone H2B type 1-K

General Information

Protein names	- Histone H2B type 1-K - H2B K - HIRA-interacting protein 1
Gene names	HIST1H2BK
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O60814

12 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
        70         80         90        100        110        120
GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT

KYTSAK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O60814-2-unknown	MPEPAK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60814-2-unknown	MPEPAK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O60814-2-unknown	MPEPAK...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60814-2-	PEPAKS...	2			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O60814-2-Acetylation	PEPAKS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O60814-6-unknown	KSAPAP...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13773
O60814-7-	SAPAPK...	7			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60814-7-	SAPAPK...	7			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60814-13-unknown	KGSKKA...	13		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9886
O60814-18-	AVTKAQ...	18			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60814-22-unknown	AQKKDG...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9887
O60814-53-unknown	TGISSK...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10870
O60814-59-unknown	AMGIMN...	59		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9888
O60814-61-	GIMNSF...	61			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60814-65-	SFVNDI...	65			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O60814-65-	SFVNDI...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O60814-65-	SFVNDI...	65			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O60814-65-	SFVNDI...	65			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MPEPAK	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13773
...APAPKK	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9886
...KAVTKA	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9887
...QVHPDT	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10870
...GISSKA	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9888
...YTSAK	126	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	5	EPAK.\|.KSAP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	12	APKK.\|.KGSK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	21	VTKA.\|.AQKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	52	HPDT.\|.TGIS	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAA_HUMAN	58	SSKA.\|.AMGI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)