P01011: Alpha-1-antichymotrypsin

General Information

Protein names	- Alpha-1-antichymotrypsin - ACT - Cell growth-inhibiting gene 24/25 protein - Serpin A3 - Alpha-1-antichymotrypsin His-Pro-less
Gene names	SERPINA3
Organism	Homo sapiens
Protease Family
Protease ID	I04.002
Chromosome location
UniProt ID	P01011

13 N-termini

6 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Alpha-1-antichymotrypsin - Isoform 3 of Alpha-1-antichymotrypsin

Sequence View

        10         20         30         40         50         60
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL
        70         80         90        100        110        120
YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ
       130        140        150        160        170        180
HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI
       190        200        210        220        230        240
NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM
       250        260        270        280        290        300
VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR
       310        320        330        340        350        360
DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK
       370        380        390        400        410        420
AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP

KQA         10         20         30         40         50         60
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL
        70         80         90        100        110        120
YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ
       130        140        150        160        170        180
HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI
       190        200        210        220        230        240
NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM
       250        260        270        280        290        300
VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR
       310        320        330        340        350        360
DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK
       370        380        390        400        410        420
AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP

KQA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

13 N-termini - 6 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01011-1-unknown	MERMLP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65882
P01011-1-unknown	MERMLP...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65883
P01011-24-unknown	HPNSPL...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01011-24-unknown	HPNSPL...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113603
P01011-24-unknown	HPNSPL...	24	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113604
P01011-26-unknown	NSPLDE...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01011-26-unknown	NSPLDE...	26		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-26-unknown	NSPLDE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114079
P01011-26-unknown	NSPLDE...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114080
P01011-34-unknown	LTQENQ...	34		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-34-unknown	LTQENQ...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180051
P01011-34-unknown	LTQENQ...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180052
P01011-341-unknown	ADLSGI...	341		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-351-unknown	NLAVSQ...	351		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-381-unknown	TLLSAL...	381		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-382-unknown	LLSALV...	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8633
P01011-383-unknown	LSALVE...	383		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01011-384-unknown	SALVET...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13912
P01011-384-unknown	SALVET...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16032
P01011-384-unknown	SALVET...	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4322
P01011-385-unknown	ALVETR...	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21716
P01011-386-unknown	LVETRT...	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21284
P01011-386-unknown	LVETRT...	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23659
P01011-386-unknown	LVETRT...	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24791
P01011-386-unknown	LVETRT...	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4323
P01011-387-unknown	VETRTI...	387	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4324

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVKITL	381	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8633
...KITLLS	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13912
...KITLLS	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16032
...KITLLS	383	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4322
...ITLLSA	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21716
...TLLSAL	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21284
...TLLSAL	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23659
...TLLSAL	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24791
...TLLSAL	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4323
...LLSALV	386	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4324
...NPKQA	423	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ELNE_HUMAN	381	KITL.\|.LLSA	inferred from experiment	unknown	MEROPS		Merops ELNE_HUMAN -> AACT_HUMAN @381
GRAM_HUMAN	383	TLLS.\|.SALV	inferred from experiment	unknown	MEROPS	Craik CS	Mahrus S et al.:Granzyme M is a regulatory prot... (S01.131)	15494398,
KLK2_HUMAN	383	TLLS.\|.SALV	inferred from experiment	unknown	MEROPS	Saedi MS	Mikolajczyk SD et al.:Prostatic human kallikrein 2 in... (S01.161)	10209959,
CATD_HUMAN	383	TLLS.\|.SALV	inferred from experiment	unknown	MEROPS	Juliano L	Pimenta DC et al.:Alpha1-antichymotrypsin and kal... (A01.009)	11131147,
MMP1_HUMAN	384	LLSA.\|.ALVE	inferred from experiment	unknown	MEROPS	Salvesen G	Mast AE et al.:Kinetics and physiologic releva... (M10.001)	1651920,
MMP13_HUMAN	385	LSAL.\|.LVET	inferred from experiment	unknown	MEROPS	Murray GI	Leeman MF et al.:The structure, regulation, and ... (M10.013)	12139441,
MMP3_HUMAN	385	LSAL.\|.LVET	inferred from experiment	unknown	MEROPS	Salvesen G	Mast AE et al.:Kinetics and physiologic releva... (M10.001)	1651920,
MMP8_HUMAN	385	LSAL.\|.LVET	inferred from experiment	unknown	MEROPS	Weiss SJ	Desrochers PE et al.:Proteolytic inactivation of alp... (M10.002)	1311327,
CATD_HUMAN	385	LSAL.\|.LVET	inferred from experiment	unknown	MEROPS	Juliano L	Pimenta DC et al.:Alpha1-antichymotrypsin and kal... (A01.009)	11131147,
CATD_HUMAN	386	SALV.\|.VETR	inferred from experiment	unknown	MEROPS	Juliano L	Pimenta DC et al.:Alpha1-antichymotrypsin and kal... (A01.009)	11131147,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)