P14314: Glucosidase 2 subunit beta

General Information

Protein names	- Glucosidase 2 subunit beta - 80K-H protein {ECO:0000303\|PubMed:2793184} - Glucosidase II subunit beta - Protein kinase C substrate 60.1 kDa protein heavy chain - PKCSH
Gene names	PRKCSH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14314

16 N-termini

12 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLLPLLLLLP MCWAVEVKRP RGVSLTNHHF YDESKPFTCL DGSATIPFDQ VNDDYCDCKD
        70         80         90        100        110        120
GSDEPGTAAC PNGSFHCTNT GYKPLYIPSN RVNDGVCDCC DGTDEYNSGV ICENTCKEKG
       130        140        150        160        170        180
RKERESLQQM AEVTREGFRL KKILIEDWKK AREEKQKKLI ELQAGKKSLE DQVEMLRTVK
       190        200        210        220        230        240
EEAEKPEREA KEQHQKLWEE QLAAAKAQQE QELAADAFKE LDDDMDGTVS VTELQTHPEL
       250        260        270        280        290        300
DTDGDGALSE AEAQALLSGD TQTDATSFYD RVWAAIRDKY RSEALPTDLP APSAPDLTEP
       310        320        330        340        350        360
KEEQPPVPSS PTEEEEEEEE EEEEEAEEEE EEEDSEEAPP PLSPPQPASP AEEDKMPPYD
       370        380        390        400        410        420
EQTQAFIDAA QEARNKFEEA ERSLKDMEES IRNLEQEISF DFGPNGEFAY LYSQCYELTT
       430        440        450        460        470        480
NEYVYRLCPF KLVSQKPKLG GSPTSLGTWG SWIGPDHDKF SAMKYEQGTG CWQGPNRSTT
       490        500        510        520
VRLLCGKETM VTSTTEPSRC EYLMELMTPA ACPEPPPEAP TEDDHDEL

Isoforms

- Isoform 2 of Glucosidase 2 subunit beta

Sequence View

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Protein Neighborhood

Domains & Features

16 N-termini - 12 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P14314-1-unknown	MLLPLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76106
P14314-15-unknown	VEVKRP...	15	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P14314-15-unknown	VEVKRP...	15	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111782
P14314-207-	AQQEQE...	207		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P14314-207-unknown	AQQEQE...	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175981
P14314-227-	GTVSVT...	227		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P14314-227-unknown	GTVSVT...	227	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171632
P14314-256-	LLSGDT...	256		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P14314-256-	LLSGDT...	256		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P14314-256-unknown	LLSGDT...	256		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P14314-256-unknown	LLSGDT...	256	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159672
P14314-257-unknown	LSGDTQ...	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13970
P14314-257-unknown	LSGDTQ...	257	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148722
P14314-258-unknown	SGDTQT...	258	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13972
P14314-258-unknown	SGDTQT...	258	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148746
P14314-261-unknown	TQTDAT...	261	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11212
P14314-261-unknown	TQTDAT...	261	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148868
P14314-364-unknown	QAFIDA...	364	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7324
P14314-364-unknown	QAFIDA...	364	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151210
P14314-369-unknown	AAQEAR...	369	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178259
P14314-369-	AAQEAR...	369		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P14314-448-unknown	TWGSWI...	448	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3646
P14314-448-unknown	TWGSWI...	448	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152710
P14314-451-unknown	SWIGPD...	451	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7326
P14314-451-unknown	SWIGPD...	451	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152768

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CKDGSD	62	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000464835
...CKDGSD	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153942
...EPGTAA	68	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465889
...EPGTAA	68	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154014
...EGFRLK	140	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465821
...EGFRLK	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154865
...LKKILI	144	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465047
...LKKILI	144	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154901
...AGKKSL	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467566
...AGKKSL	168	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155241
...EAQALL	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13970
...EAQALL	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132097
...AQALLS	257	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13972
...AQALLS	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132122
...LLSGDT	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11212
...LLSGDT	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132245
...YDEQTQ	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7324
...PTSLGT	447	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3646
...PTSLGT	447	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136130
...LGTWGS	450	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7326
...LGTWGS	450	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136189
...DHDEL	528	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DHDEL	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt71724

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	256	QALL.\|.LSGD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	257	ALLS.\|.SGDT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	260	SGDT.\|.TQTD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATS_HUMAN	363	EQTQ.\|.QAFI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	447	SLGT.\|.TWGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	450	TWGS.\|.SWIG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)