P27635: 60S ribosomal protein L10 {ECO:0000305}

General Information

Protein names	- 60S ribosomal protein L10 {ECO:0000305} - Laminin receptor homolog - Large ribosomal subunit protein uL16 {ECO:0000303\|PubMed:24524803} - Protein QM - Ribosomal protein L10 {ECO:0000312\|HGNC:HGNC:10298} - Tumor suppressor QM
Gene names	RPL10
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P27635

16 N-termini

9 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG HMVSDEYEQL
        70         80         90        100        110        120
SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
       130        140        150        160        170        180
KPQGTVARVH IGQVIMSIRT KLQNKEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
       190        200        210
FEDMVAEKRL IPDGCGVKYI PNRGPLDKWR ALHS

Isoforms

Sequence View

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

16 N-termini - 9 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P27635-2-unknown	GRRPAR...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P27635-11-unknown	YCKNKP...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10049
P27635-18-unknown	PKSRFC...	18	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475612
P27635-18-unknown	PKSRFC...	18	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406125
P27635-49-unknown	CGHMVS...	49	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14066
P27635-50-	GHMVSD...	50		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27635-50-	GHMVSD...	50		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P27635-52-	MVSDEY...	52		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27635-52-	MVSDEY...	52		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P27635-52-unknown	MVSDEY...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475742
P27635-52-unknown	MVSDEY...	52	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385621
P27635-56-unknown	EYEQLS...	56	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11387
P27635-61-unknown	SSEALE...	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14067
P27635-86-unknown	HIRVRL...	86	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P27635-91-unknown	LHPFHV...	91	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475777
P27635-91-unknown	LHPFHV...	91	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475840
P27635-91-unknown	LHPFHV...	91	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405064
P27635-91-unknown	LHPFHV...	91	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000398047
P27635-117-	GAFGKP...	117		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P27635-117-	GAFGKP...	117		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P27635-117-	GAFGKP...	117		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P27635-117-	GAFGKP...	117		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P27635-117-unknown	GAFGKP...	117	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10050
P27635-177-unknown	NADEFE...	177		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P27635-180-unknown	EFEDMV...	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11388
P27635-181-unknown	FEDMVA...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11389

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARCYRY	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10049
...DEFPLC	48	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14066
...HMVSDE	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11387
...EYEQLS	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14067
...QTGMRG	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10050
...KFNADE	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11388
...FNADEF	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11389
...GVKYIP	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475185
...GVKYIP	200	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388600
...RALHS	214	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	10	CYRY.\|.YCKN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	48	FPLC.\|.CGHM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	55	VSDE.\|.EYEQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	60	EQLS.\|.SSEA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	116	GMRG.\|.GAFG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAB_HUMAN	179	NADE.\|.EFED	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	180	ADEF.\|.FEDM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)