P54105: Methylosome subunit pICln

General Information

Protein names	- Methylosome subunit pICln - Chloride channel, nucleotide sensitive 1A - Chloride conductance regulatory protein ICln - I(Cln) - Chloride ion current inducer protein - ClCI - Reticulocyte pICln
Gene names	CLNS1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P54105

8 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSFLKSFPPP GPAEGLLRQQ PDTEAVLNGK GLGTGTLYIA ESRLSWLDGS GLGFSLEYPT
        70         80         90        100        110        120
ISLHALSRDR SDCLGEHLYV MVNAKFEEES KEPVADEEEE DSDDDVEPIT EFRFVPSDKS
       130        140        150        160        170        180
ALEAMFTAMC ECQALHPDPE DEDSDDYDGE EYDVEAHEQG QGDIPTFYTY EEGLSHLTAE
       190        200        210        220        230
GQATLERLEG MLSQSVSSQY NMAGVRTEDS IRDYEDGMEV DTTPTVAGQF EDADVDH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P54105-2-unknown	MSFLKS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54105-2-Acetylation	SFLKSF...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P54105-2-Acetylation	SFLKSF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P54105-2-Acetylation	SFLKSF...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P54105-2-Acetylation	SFLKSF...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P54105-6-	SFPPPG...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P54105-6-	SFPPPG...	6			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P54105-6-	SFPPPG...	6			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P54105-6-	SFPPPG...	6			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P54105-6-	SFPPPG...	6			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P54105-85-	KFEEES...	85			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P54105-169-	TYEEGL...	169			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P54105-178-unknown	TAEGQA...	178		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14206
P54105-195-	SVSSQY...	195			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P54105-195-	SVSSQY...	195			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P54105-195-	SVSSQY...	195			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P54105-200-unknown	YNMAGV...	200		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11673

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GLSHLT	177	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14206
...SVSSQY	199	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11673
...ADVDH	237	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ADVDH	237		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ADVDH	237		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	177	SHLT.\|.TAEG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	199	SSQY.\|.YNMA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)