P62942: Peptidyl-prolyl cis-trans isomerase FKBP1A

General Information

Protein names	- Peptidyl-prolyl cis-trans isomerase FKBP1A - PPIase FKBP1A - 5.2.1.8 {ECO:0000269\|PubMed:1696686, ECO:0000269\|PubMed:1701173} - 12 kDa FK506-binding protein - 12 kDa FKBP - FKBP-12 - Calstabin-1 - FK506-binding protein 1A - FKBP-1A - Immunophilin FKBP12 - Rotamase
Gene names	FKBP1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P62942

9 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFM LGKQEVIRGW
70 80 90 100
EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF DVELLKLE

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P62942-2-unknown	MGVQVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62942-2-unknown	MGVQVE...	1			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P62942-2-unknown	MGVQVE...	1			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P62942-2-unknown	MGVQVE...	1			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P62942-2-	GVQVET...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P62942-2-	GVQVET...	2			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P62942-2-Acetylation	GVQVET...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P62942-27-unknown	YTGMLE...	27		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3899
P62942-29-	GMLEDG...	29			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62942-49-	FMLGKQ...	49			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P62942-49-	FMLGKQ...	49			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P62942-81-unknown	YAYGAT...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11786
P62942-85-unknown	ATGHPG...	85		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3900
P62942-99-	VFDVEL...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P62942-99-	VFDVEL...	99			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TCVVHY	26	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3899
...TISPDY	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11786
...DYAYGA	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3900
...LLKLE	108	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	26	VVHY.\|.YTGM	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	80	SPDY.\|.YAYG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	84	AYGA.\|.ATGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)