P78417: Glutathione S-transferase omega-1

General Information

Protein names	- Glutathione S-transferase omega-1 - GSTO-1 - 2.5.1.18 {ECO:0000269\|PubMed:10783391, ECO:0000269\|PubMed:11511179, ECO:0000269\|PubMed:17226937, ECO:0000269\|PubMed:18028863, ECO:0000269\|PubMed:21106529} - Glutathione S-transferase omega 1-1 - GSTO 1-1 - Glutathione-dependent dehydroascorbate reductase - 1.8.5.1 {ECO:0000269\|PubMed:10783391, ECO:0000269\|PubMed:11511179} - Monomethylarsonic acid reductase - MMA(V) reductase - 1.20.4.2 {ECO:0000269\|PubMed:11511179} - S-(Phenacyl)glutathione reductase - SPG-R
Gene names	GSTO1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P78417

10 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Glutathione S-transferase omega-1 - Isoform 3 of Glutathione S-transferase omega-1

Sequence View

        10         20         30         40         50         60
MSGESARSLG KGSAPPGPVP EGSIRIYSMR FCPFAERTRL VLKAKGIRHE VININLKNKP
        70         80         90        100        110        120
EWFFKKNPFG LVPVLENSQG QLIYESAITC EYLDEAYPGK KLLPDDPYEK ACQKMILELF
       130        140        150        160        170        180
SKVPSLVGSF IRSQNKEDYA GLKEEFRKEF TKLEEVLTNK KTTFFGGNSI SMIDYLIWPW
       190        200        210        220        230        240
FERLEAMKLN ECVDHTPKLK LWMAAMKEDP TVSALLTSEK DWQGFLELYL QNSPEACDYG

L         10         20         30         40         50         60
MSGESARSLG KGSAPPGPVP EGSIRIYSMR FCPFAERTRL VLKAKGIRHE VININLKNKP
        70         80         90        100        110        120
EWFFKKNPFG LVPVLENSQG QLIYESAITC EYLDEAYPGK KLLPDDPYEK ACQKMILELF
       130        140        150        160        170        180
SKVPSLVGSF IRSQNKEDYA GLKEEFRKEF TKLEEVLTNK KTTFFGGNSI SMIDYLIWPW
       190        200        210        220        230        240
FERLEAMKLN ECVDHTPKLK LWMAAMKEDP TVSALLTSEK DWQGFLELYL QNSPEACDYG

L

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P78417-2-unknown	MSGESA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78417-1-unknown	MSGESA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76600
P78417-2-Acetylation	SGESAR...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P78417-2-Acetylation	SGESAR...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110883
P78417-8-	SLGKGS...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P78417-8-	SLGKGS...	8			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P78417-8-	SLGKGS...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P78417-8-	SLGKGS...	8			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P78417-8-acetylation	SLGKGS...	8	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P78417-8-acetylation	SLGKGS...	8	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182987
P78417-8-unknown	SLGKGS...	8		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172612
P78417-14-unknown	APPGPV...	14		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17813
P78417-14-unknown	APPGPV...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136499
P78417-29-unknown	MRFCPF...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76601
P78417-29-unknown	MRFCPF...	29		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99063
P78417-139-unknown	YAGLKE...	139		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17815
P78417-139-unknown	YAGLKE...	139		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143009
P78417-160-unknown	KKTTFF...	160		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14313
P78417-160-unknown	KKTTFF...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143984
P78417-160-unknown	KKTTFF...	160		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197435

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGKGSA	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17813
...QNKEDY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17815
...QNKEDY	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126218
...EVLTNK	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14313
...EVLTNK	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127227
...CDYGL	241	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CDYGL	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72218
...CDYGL	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72219

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	13	KGSA.\|.APPG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	138	KEDY.\|.YAGL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAM_HUMAN	159	LTNK.\|.KKTT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)