Q8NE71: ATP-binding cassette sub-family F member 1

General Information

Protein names	- ATP-binding cassette sub-family F member 1 - ATP-binding cassette 50 - TNF-alpha-stimulated ABC protein
Gene names	ABCF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NE71

18 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK
        70         80         90        100        110        120
EKEQQQQQQQ QQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPTSD EEDEVPAPKP
       130        140        150        160        170        180
RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE
       190        200        210        220        230        240
EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQGSEE EGEGEEEEEE
       250        260        270        280        290        300
GGESKADDPY AHLSKKEKKK LKKQMEYERQ VASLKAANAA ENDFSVSQAE MSSRQAMLEN
       310        320        330        340        350        360
ASDIKLEKFS ISAHGKELFV NADLYIVAGR RYGLVGPNGK GKTTLLKHIA NRALSIPPNI
       370        380        390        400        410        420
DVLLCEQEVV ADETPAVQAV LRADTKRLKL LEEERRLQGQ LEQGDDTAAE RLEKVYEELR
       430        440        450        460        470        480
ATGAAAAEAK ARRILAGLGF DPEMQNRPTQ KFSGGWRMRV SLARALFMEP TLLMLDEPTN
       490        500        510        520        530        540
HLDLNAVIWL NNYLQGWRKT LLIVSHDQGF LDDVCTDIIH LDAQRLHYYR GNYMTFKKMY
       550        560        570        580        590        600
QQKQKELLKQ YEKQEKKLKE LKAGGKSTKQ AEKQTKEALT RKQQKCRRKN QDEESQEAPE
       610        620        630        640        650        660
LLKRPKEYTV RFTFPDPPPL SPPVLGLHGV TFGYQGQKPL FKNLDFGIDM DSRICIVGPN
       670        680        690        700        710        720
GVGKSTLLLL LTGKLTPTHG EMRKNHRLKI GFFNQQYAEQ LRMEETPTEY LQRGFNLPYQ
       730        740        750        760        770        780
DARKCLGRFG LESHAHTIQI CKLSGGQKAR VVFAELACRE PDVLILDEPT NNLDIESIDA
       790        800        810        820        830        840
LGEAINEYKG AVIVVSHDAR LITETNCQLW VVEEQSVSQI DGDFEDYKRE VLEALGEVMV

SRPRE

Isoforms

- Isoform 2 of ATP-binding cassette sub-family F member 1

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

18 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NE71-1-unknown	MPKAPK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NE71-1-unknown	MPKAPK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt65988
Q8NE71-46-unknown	AVEDKQ...	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14765
Q8NE71-46-unknown	AVEDKQ...	46	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138841
Q8NE71-105-	SVPTSD...	105		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q8NE71-105-	SVPTSD...	105		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8NE71-105-unknown	SVPTSD...	105	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164934
Q8NE71-136-unknown	IQDQSE...	136	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14767
Q8NE71-136-unknown	IQDQSE...	136	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144141
Q8NE71-139-unknown	QSEEEE...	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12904
Q8NE71-139-unknown	QSEEEE...	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144254
Q8NE71-275-unknown	KAANAA...	275	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14769
Q8NE71-275-unknown	KAANAA...	275	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147976
Q8NE71-276-	AANAAE...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8NE71-276-	AANAAE...	276		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8NE71-276-	AANAAE...	276		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8NE71-276-unknown	AANAAE...	276	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167334
Q8NE71-279-unknown	AAENDF...	279	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14771
Q8NE71-279-unknown	AAENDF...	279	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148152
Q8NE71-284-unknown	FSVSQA...	284	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167336
Q8NE71-284-	FSVSQA...	284		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8NE71-284-	FSVSQA...	284		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8NE71-284-	FSVSQA...	284		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8NE71-284-	FSVSQA...	284		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8NE71-284-	FSVSQA...	284		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8NE71-285-unknown	SVSQAE...	285	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172260
Q8NE71-285-	SVSQAE...	285		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8NE71-285-	SVSQAE...	285		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8NE71-285-	SVSQAE...	285		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q8NE71-285-	SVSQAE...	285		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8NE71-373-unknown	ETPAVQ...	373	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12906
Q8NE71-373-unknown	ETPAVQ...	373	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150614
Q8NE71-438-unknown	LGFDPE...	438	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4156
Q8NE71-438-unknown	LGFDPE...	438	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152000
Q8NE71-780-unknown	ALGEAI...	780	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175198
Q8NE71-780-	ALGEAI...	780		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FFEELA	45	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14765
...FFEELA	45	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121903
...VFAALI	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14767
...VFAALI	135	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127392
...ALIQDQ	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12904
...ALIQDQ	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127509
...QVASLK	274	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14769
...LKAANA	278	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14771
...EVVADE	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12906
...EVVADE	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134012
...RILAGL	437	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4156
...RILAGL	437	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135409
...SRPRE	845	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRPRE	845	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61606

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	45	EELA.\|.AVED	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	135	AALI.\|.IQDQ	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	138	IQDQ.\|.QSEE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAM_HUMAN	274	ASLK.\|.KAAN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	278	AANA.\|.AAEN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	372	VADE.\|.ETPA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	437	LAGL.\|.LGFD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)