Q92734: Protein TFG

General Information

Protein names	- Protein TFG - TRK-fused gene protein
Gene names	TFG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92734

17 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein TFG - Isoform 3 of Protein TFG - Isoform 4 of Protein TFG

Sequence View

        10         20         30         40         50         60
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD
        70         80         90        100        110        120
EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL
       130        140        150        160        170        180
DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN
       190        200        210        220        230        240
VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE
       250        260        270        280        290        300
GQMYQQYQQQ AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
       310        320        330        340        350        360
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA PSQPGAYQPR
       370        380        390        400
PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR         10         20         30         40         50         60
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD
        70         80         90        100        110        120
EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL
       130        140        150        160        170        180
DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN
       190        200        210        220        230        240
VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE
       250        260        270        280        290        300
GQMYQQYQQQ AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
       310        320        330        340        350        360
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA PSQPGAYQPR
       370        380        390        400
PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR         10         20         30         40         50         60
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS NDEVTIKYKD
        70         80         90        100        110        120
EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS QVKYLRRELI ELRNKVNRLL
       130        140        150        160        170        180
DSLEPPGEPG PSTNIPENDT VDGREEKSAS DSSGKQSTQV MAASMSAFDP LKNQDEINKN
       190        200        210        220        230        240
VMSAFGLTDD QVSGPPSAPA EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE
       250        260        270        280        290        300
GQMYQQYQQQ AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
       310        320        330        340        350        360
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA PSQPGAYQPR
       370        380        390        400
PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

17 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92734-1-Acetylation	MNGQLD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92734-1-Acetylation	MNGQLD...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q92734-1-Acetylation	MNGQLD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100603
Q92734-1-unknown	MNGQLD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt92002
Q92734-99-unknown	SSQVKY...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7984
Q92734-99-unknown	SSQVKY...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142335
Q92734-143-	GREEKS...	143			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92734-143-unknown	GREEKS...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177808
Q92734-162-unknown	AASMSA...	162		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166909
Q92734-162-	AASMSA...	162			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92734-162-	AASMSA...	162			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92734-164-	SMSAFD...	164			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q92734-164-	SMSAFD...	164			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92734-164-	SMSAFD...	164			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92734-164-unknown	SMSAFD...	164		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164428
Q92734-166-unknown	SAFDPL...	166		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt166907
Q92734-166-	SAFDPL...	166			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q92734-166-	SAFDPL...	166			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92734-166-	SAFDPL...	166			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92734-166-	SAFDPL...	166			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92734-183-unknown	SAFGLT...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14803
Q92734-183-unknown	SAFGLT...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146015
Q92734-183-	SAFGLT...	183			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92734-183-	SAFGLT...	183			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92734-183-	SAFGLT...	183			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q92734-186-	GLTDDQ...	186			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q92734-186-unknown	GLTDDQ...	186			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q92734-186-unknown	GLTDDQ...	186		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162217
Q92734-194-unknown	GPPSAP...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7986
Q92734-194-unknown	GPPSAP...	194		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146379
Q92734-290-unknown	GYGQQP...	290		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4172
Q92734-290-unknown	GYGQQP...	290		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149486

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PRPLES	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7984
...PRPLES	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125526
...NKNVMS	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14803
...NKNVMS	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129314
...DDQVSG	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7986
...DDQVSG	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129684
...PQQFQG	289	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4172
...PQQFQG	289	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132870
...GPGYR	400	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPGYR	400	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87620

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	98	PLES.\|.SSQV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	182	NVMS.\|.SAFG	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	193	QVSG.\|.GPPS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	289	QFQG.\|.GYGQ	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)