Q92841: Probable ATP-dependent RNA helicase DDX17
Protein names | - Probable ATP-dependent RNA helicase DDX17 - 3.6.4.13 - DEAD box protein 17 - DEAD box protein p72 - DEAD box protein p82 {ECO:0000303|PubMed:19995069} - RNA-dependent helicase p72 |
---|---|
Gene names | DDX17 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q92841 |
26
N-termini
4
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ
70 80 90 100 110 120
ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK
130 140 150 160 170 180
KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ
190 200 210 220 230 240
YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE
250 260 270 280 290 300
RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
310 320 330 340 350 360
TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP
370 380 390 400 410 420
KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK
430 440 450 460 470 480
TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR
490 500 510 520 530 540
GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA
550 560 570 580 590 600
NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
610 620 630 640 650 660
SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY
670 680 690 700 710 720
GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP
PPPPPPSRK
Isoforms
- Isoform 2 of Probable ATP-dependent RNA helicase DDX17 - Isoform 3 of Probable ATP-dependent RNA helicase DDX17 - Isoform 4 of Probable ATP-dependent RNA helicase DDX17Sequence View
10 20 30 40 50 60
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ
70 80 90 100 110 120
ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK
130 140 150 160 170 180
KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ
190 200 210 220 230 240
YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE
250 260 270 280 290 300
RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
310 320 330 340 350 360
TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP
370 380 390 400 410 420
KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK
430 440 450 460 470 480
TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR
490 500 510 520 530 540
GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA
550 560 570 580 590 600
NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
610 620 630 640 650 660
SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY
670 680 690 700 710 720
GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP
PPPPPPSRK
10 20 30 40 50 60
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ
70 80 90 100 110 120
ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK
130 140 150 160 170 180
KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ
190 200 210 220 230 240
YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE
250 260 270 280 290 300
RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
310 320 330 340 350 360
TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP
370 380 390 400 410 420
KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK
430 440 450 460 470 480
TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR
490 500 510 520 530 540
GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA
550 560 570 580 590 600
NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
610 620 630 640 650 660
SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY
670 680 690 700 710 720
GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP
PPPPPPSRK
10 20 30 40 50 60
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP PSVVTRPEPQ
70 80 90 100 110 120
ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR GGGGLPPKKF GNPGERLRKK
130 140 150 160 170 180
KWDLSELPKF EKNFYVEHPE VARLTPYEVD ELRRKKEITV RGGDVCPKPV FAFHHANFPQ
190 200 210 220 230 240
YVMDVLMDQH FTEPTPIQCQ GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE
250 260 270 280 290 300
RGDGPICLVL APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
310 320 330 340 350 360
TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR QTLMWSATWP
370 380 390 400 410 420
KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES EKDHKLIQLM EEIMAEKENK
430 440 450 460 470 480
TIIFVETKRR CDDLTRRMRR DGWPAMCIHG DKSQPERDWV LNEFRSGKAP ILIATDVASR
490 500 510 520 530 540
GLDVEDVKFV INYDYPNSSE DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA
550 560 570 580 590 600
NQAINPKLMQ LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
610 620 630 640 650 660
SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY TAQEYGAGTY
670 680 690 700 710 720
GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP PGATNMIGYM GQTAYQYPPP
PPPPPPSRK
Protein Neighborhood
Domains & Features
26 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q92841-1-unknown | MPTGFV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92841-9-unknown | ILCVLL... | 9 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q92841-24- | VASATG... | 24 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q92841-24- | VASATG... | 24 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-37- | SAAPAA... | 37 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q92841-61- | ALPSPA... | 61 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q92841-61- | ALPSPA... | 61 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q92841-61- | ALPSPA... | 61 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q92841-80-unknown | MRGGGF... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72533 | |||
Q92841-80-unknown | MRGGGF... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72534 | |||
Q92841-80-unknown | MRGGGF... | 80 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000371046 | |||
Q92841-101-unknown | GGGGLP... | 101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10456 | |||
Q92841-101-unknown | GGGGLP... | 101 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137031 | |||
Q92841-101-unknown | GGGGLP... | 101 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137032 | |||
Q92841-109-unknown | KFGNPG... | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169717 | |||
Q92841-109-unknown | KFGNPG... | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169718 | |||
Q92841-109- | KFGNPG... | 109 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q92841-133- | NFYVEH... | 133 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-133- | NFYVEH... | 133 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q92841-133-unknown | NFYVEH... | 133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173371 | |||
Q92841-133-unknown | NFYVEH... | 133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173372 | |||
Q92841-134-unknown | FYVEHP... | 134 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167162 | |||
Q92841-134-unknown | FYVEHP... | 134 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167163 | |||
Q92841-134- | FYVEHP... | 134 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q92841-134- | FYVEHP... | 134 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-134- | FYVEHP... | 134 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q92841-134- | FYVEHP... | 134 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
Q92841-134- | FYVEHP... | 134 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q92841-259- | QVQQVA... | 259 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-259-unknown | QVQQVA... | 259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172367 | |||
Q92841-259-unknown | QVQQVA... | 259 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt172368 | |||
Q92841-477-unknown | VASRGL... | 477 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13012 | |||
Q92841-477-unknown | VASRGL... | 477 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151976 | |||
Q92841-549-unknown | MQLVDH... | 549 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000400766 | |||
Q92841-549-unknown | MQLVDH... | 549 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt130109 | |||
Q92841-646- | GTSSYT... | 646 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-646-unknown | GTSSYT... | 646 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173367 | |||
Q92841-646-unknown | GTSSYT... | 646 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt173368 | |||
Q92841-651-unknown | TAQEYG... | 651 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14806 | |||
Q92841-651-unknown | TAQEYG... | 651 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154257 | |||
Q92841-651-unknown | TAQEYG... | 651 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154258 | |||
Q92841-656- | GAGTYG... | 656 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92841-656- | GAGTYG... | 656 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q92841-656-unknown | GAGTYG... | 656 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171291 | |||
Q92841-656-unknown | GAGTYG... | 656 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171292 | |||
Q92841-661-unknown | GASSTT... | 661 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167166 | |||
Q92841-661-unknown | GASSTT... | 661 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt167167 | |||
Q92841-661- | GASSTT... | 661 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q92841-671-unknown | SSQSSS... | 671 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175327 | |||
Q92841-671-unknown | SSQSSS... | 671 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175328 | |||
Q92841-671- | SSQSSS... | 671 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q92841-671- | SSQSSS... | 671 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GFGARG | 100 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10456 | |||
...GFGARG | 100 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt119875 | |||
...GFGARG | 100 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt119876 | |||
...LIATDV | 476 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13012 | |||
...LIATDV | 476 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135384 | |||
...GTSSYT | 650 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14806 | |||
...GTSSYT | 650 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137678 | |||
...GTSSYT | 650 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137679 | |||
...PPSRK | 729 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PPSRK | 729 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68151 | |||
...PPSRK | 729 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt68152 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAA_HUMAN | 100 | GARG.|.GGGG | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:The substrate specificity profi... (S01.135) | 20536382, |
GRAB_HUMAN | 476 | ATDV.|.VASR | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
GRAM_HUMAN | 650 | SSYT.|.TAQE | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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