Q9NT62: Ubiquitin-like-conjugating enzyme ATG3

General Information

Protein names	- Ubiquitin-like-conjugating enzyme ATG3 - 2.3.2.- - Autophagy-related protein 3 - APG3-like - hApg3 - Protein PC3-96
Gene names	ATG3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NT62

10 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQNVINTVKG KALEVAEYLT PVLKESKFKE TGVITPEEFV AAGDHLVHHC PTWQWATGEE
        70         80         90        100        110        120
LKVKAYLPTG KQFLVTKNVP CYKRCKQMEY SDELEAIIEE DDGDGGWVDT YHNTGITGIT
       130        140        150        160        170        180
EAVKEITLEN KDNIRLQDCS ALCEEEEDED EGEAADMEEY EESGLLETDE ATLDTRKIVE
       190        200        210        220        230        240
ACKAKTDAGG EDAILQTRTY DLYITYDKYY QTPRLWLFGY DEQRQPLTVE HMYEDISQDH
       250        260        270        280        290        300
VKKTVTIENH PHLPPPPMCS VHPCRHAEVM KKIIETVAEG GGELGVHMYL LIFLKFVQAV
       310
IPTIEYDYTR HFTM

Isoforms

- Isoform 2 of Ubiquitin-like-conjugating enzyme ATG3

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NT62-1-unknown	MQNVIN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67877
Q9NT62-1-Acetylation	MQNVIN...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NT62-1-Acetylation	MQNVIN...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NT62-1-Acetylation	MQNVIN...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9NT62-1-Acetylation	MQNVIN...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107073
Q9NT62-10-unknown	GKALEV...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt164667
Q9NT62-10-	GKALEV...	10			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9NT62-10-	GKALEV...	10			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9NT62-42-unknown	AGDHLV...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8106
Q9NT62-42-unknown	AGDHLV...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138523
Q9NT62-105-unknown	GGWVDT...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165616
Q9NT62-105-	GGWVDT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9NT62-105-	GGWVDT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NT62-105-	GGWVDT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9NT62-105-	GGWVDT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9NT62-105-	GGWVDT...	105			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9NT62-122-unknown	AVKEIT...	122		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167373
Q9NT62-122-	AVKEIT...	122			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9NT62-183-unknown	KAKTDA...	183		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15047
Q9NT62-183-unknown	KAKTDA...	183		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146011

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EEFVAA	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8106
...EEFVAA	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121571
...IVEACK	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15047
...IVEACK	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129310
...RHFTM	314	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	41	FVAA.\|.AGDH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	182	EACK.\|.KAKT	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)