Q9UBE0: SUMO-activating enzyme subunit 1

General Information

Protein names	- SUMO-activating enzyme subunit 1 - Ubiquitin-like 1-activating enzyme E1A - SUMO-activating enzyme subunit 1, N-terminally processed
Gene names	SAE1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UBE0

15 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of SUMO-activating enzyme subunit 1 - Isoform 3 of SUMO-activating enzyme subunit 1

Sequence View

        10         20         30         40         50         60
MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV
        70         80         90        100        110        120
KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE
       130        140        150        160        170        180
SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK
       190        200        210        220        230        240
VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY
       250        260        270        280        290        300
FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA
       310        320        330        340
PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK         10         20         30         40         50         60
MVEKEEAGGG ISEEEAAQYD RQIRLWGLEA QKRLRASRVL LVGLKGLGAE IAKNLILAGV
        70         80         90        100        110        120
KGLTMLDHEQ VTPEDPGAQF LIRTGSVGRN RAEASLERAQ NLNPMVDVKV DTEDIEKKPE
       130        140        150        160        170        180
SFFTQFDAVC LTCCSRDVIV KVDQICHKNS IKFFTGDVFG YHGYTFANLG EHEFVEEKTK
       190        200        210        220        230        240
VAKVSQGVED GPDTKRAKLD SSETTMVKKK VVFCPVKEAL EVDWSSEKAK AALKRTTSDY
       250        260        270        280        290        300
FLLQVLLKFR TDKGRDPSSD TYEEDSELLL QIRNDVLDSL GISPDLLPED FVRYCFSEMA
       310        320        330        340
PVCAVVGGIL AQEIVKALSQ RDPPHNNFFF FDGMKGNGIV ECLGPK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UBE0-1-unknown	MVEKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88833
Q9UBE0-1-unknown	MVEKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88834
Q9UBE0-1-	MVEKEE...	1			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UBE0-1-	MVEKEE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UBE0-1-	MVEKEE...	1			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UBE0-1-Acetylation	MVEKEE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UBE0-1-Acetylation	MVEKEE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UBE0-1-Acetylation	MVEKEE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UBE0-1-Acetylation	MVEKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103631
Q9UBE0-1-Acetylation	MVEKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103632
Q9UBE0-2-unknown	VEKEEA...	2			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9UBE0-2-unknown	VEKEEA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9UBE0-2-unknown	VEKEEA...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UBE0-2-unknown	VEKEEA...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162063
Q9UBE0-2-unknown	VEKEEA...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162064
Q9UBE0-2-Acetylation	VEKEEA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UBE0-2-Acetylation	VEKEEA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110983
Q9UBE0-2-Acetylation	VEKEEA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110984
Q9UBE0-2-	VEKEEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9UBE0-2-	VEKEEA...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9UBE0-2-	VEKEEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UBE0-2-	VEKEEA...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9UBE0-2-	VEKEEA...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UBE0-10-unknown	GISEEE...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173276
Q9UBE0-10-unknown	GISEEE...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173277
Q9UBE0-10-	GISEEE...	10			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9UBE0-99-	AQNLNP...	99			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9UBE0-99-unknown	AQNLNP...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177957
Q9UBE0-99-unknown	AQNLNP...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177958
Q9UBE0-171-unknown	EHEFVE...	171		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8125
Q9UBE0-171-unknown	EHEFVE...	171		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145570
Q9UBE0-171-unknown	EHEFVE...	171		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145571
Q9UBE0-286-unknown	LLPEDF...	286		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13498
Q9UBE0-304-unknown	AVVGGI...	304		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4272
Q9UBE0-305-unknown	VVGGIL...	305		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4273
Q9UBE0-308-unknown	GILAQE...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4274

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FANLGE	170	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8125
...FANLGE	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128868
...FANLGE	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128869
...GISPDL	285	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13498
...MAPVCA	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4272
...APVCAV	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4273
...CAVVGG	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4274
...CLGPK	346	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	170	NLGE.\|.EHEF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	285	SPDL.\|.LLPE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATB_HUMAN	303	PVCA.\|.AVVG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	304	VCAV.\|.VVGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	307	VVGG.\|.GILA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)