O75367: Core histone macro-H2A.1

General Information

Protein names	- Core histone macro-H2A.1 - Histone macroH2A1 - mH2A1 - Histone H2A.y - H2A/y - Medulloblastoma antigen MU-MB-50.205
Gene names	H2AFY
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75367

11 N-termini

5 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Core histone macro-H2A.1 - Isoform 3 of Core histone macro-H2A.1

Sequence View

        10         20         30         40         50         60
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI
        70         80         90        100        110        120
LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS
       130        140        150        160        170        180
KGKLEAIITP PPAKKAKSPS QKKPVSKKAG GKKGARKSKK KQGEVSKAAS ADSTTEGTPA
       190        200        210        220        230        240
DGFTVLSTKS LFLGQKLNLI HSEISNLAGF EVEAIINPTN ADIDLKDDLG NTLEKKGGKE
       250        260        270        280        290        300
FVEAVLELRK KNGPLEVAGA AVSAGHGLPA KFVIHCNSPV WGADKCEELL EKTVKNCLAL
       310        320        330        340        350        360
ADDKKLKSIA FPSIGSGRNG FPKQTAAQLI LKAISSYFVS TMSSSIKTVY FVLFDSESIG
       370
IYVQEMAKLD AN         10         20         30         40         50         60
MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI
        70         80         90        100        110        120
LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS
       130        140        150        160        170        180
KGKLEAIITP PPAKKAKSPS QKKPVSKKAG GKKGARKSKK KQGEVSKAAS ADSTTEGTPA
       190        200        210        220        230        240
DGFTVLSTKS LFLGQKLNLI HSEISNLAGF EVEAIINPTN ADIDLKDDLG NTLEKKGGKE
       250        260        270        280        290        300
FVEAVLELRK KNGPLEVAGA AVSAGHGLPA KFVIHCNSPV WGADKCEELL EKTVKNCLAL
       310        320        330        340        350        360
ADDKKLKSIA FPSIGSGRNG FPKQTAAQLI LKAISSYFVS TMSSSIKTVY FVLFDSESIG
       370
IYVQEMAKLD AN

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75367-1-unknown	MSSRGG...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75367-1-unknown	MSSRGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76696
O75367-1-unknown	MSSRGG...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76697
O75367-5-unknown	GGKKKS...	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9900
O75367-5-unknown	GGKKKS...	5	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194663
O75367-5-unknown	GGKKKS...	5	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194664
O75367-57-unknown	TAEILE...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13831
O75367-57-unknown	TAEILE...	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9901
O75367-57-unknown	TAEILE...	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139637
O75367-57-unknown	TAEILE...	57	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139638
O75367-58-unknown	AEILEL...	58	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9904
O75367-58-unknown	AEILEL...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139759
O75367-58-unknown	AEILEL...	58	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139760
O75367-82-	LLAVAN...	82		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75367-82-unknown	LLAVAN...	82	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168994
O75367-82-unknown	LLAVAN...	82	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168995
O75367-126-unknown	AIITPP...	126	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16945
O75367-126-unknown	AIITPP...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143724
O75367-126-unknown	AIITPP...	126	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143725
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
O75367-173-	STTEGT...	173		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
O75367-173-unknown	STTEGT...	173	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10941
O75367-173-unknown	STTEGT...	173		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
O75367-173-unknown	STTEGT...	173	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145604
O75367-173-unknown	STTEGT...	173	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145644
O75367-177-	GTPADG...	177		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
O75367-177-unknown	GTPADG...	177	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165553
O75367-177-unknown	GTPADG...	177	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165554

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VLEYLT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13831
...VLEYLT	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9901
...VLEYLT	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122732
...VLEYLT	56	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122733
...LEYLTA	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9904
...LEYLTA	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122858
...LEYLTA	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122859
...KGKLEA	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16945
...KGKLEA	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126967
...KGKLEA	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126968
...AASADS	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10941
...AASADS	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128943
...KLDAN	372	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KLDAN	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72314
...KLDAN	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72315

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	4	SSRG.\|.GGKK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	56	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAA_HUMAN	56	EYLT.\|.TAEI	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	57	YLTA.\|.AEIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
MEP1A_HUMAN	125	KLEA.\|.AIIT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	172	SADS.\|.STTE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)