O75533: Splicing factor 3B subunit 1
Protein names | - Splicing factor 3B subunit 1 - Pre-mRNA-splicing factor SF3b 155 kDa subunit - SF3b155 - Spliceosome-associated protein 155 - SAP 155 |
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Gene names | SF3B1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O75533 |
28
N-termini
7
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR FAGYVTSIAA
70 80 90 100 110 120
TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ YDPFAEHRPP KIADREDEYK
130 140 150 160 170 180
KHRRTMIISP ERLDPFADGG KTPDPKMNAR TYMDVMREQH LTKEEREIRQ QLAEKAKAGE
190 200 210 220 230 240
LKVVNGAAAS QPPSKRKRRW DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK
250 260 270 280 290 300
GSETPGATPG SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
310 320 330 340 350 360
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST PVLTPGKTPI
370 380 390 400 410 420
GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS DEELDAMFPE GYKVLPPPAG
430 440 450 460 470 480
YVPIRTPARK LTATPTPLGG MTGFHMQTED RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV
490 500 510 520 530 540
DVDESTLSPE EQKERKIMKL LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM
550 560 570 580 590 600
SPTLEDQERH LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
610 620 630 640 650 660
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA VCKSKKSWQA
670 680 690 700 710 720
RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK VRTISALAIA ALAEAATPYG
730 740 750 760 770 780
IESFDSVLKP LWKGIRQHRG KGLAAFLKAI GYLIPLMDAE YANYYTREVM LILIREFQSP
790 800 810 820 830 840
DEEMKKIVLK VVKQCCGTDG VEANYIKTEI LPPFFKHFWQ HRMALDRRNY RQLVDTTVEL
850 860 870 880 890 900
ANKVGAAEII SRIVDDLKDE AEQYRKMVME TIEKIMGNLG AADIDHKLEE QLIDGILYAF
910 920 930 940 950 960
QEQTTEDSVM LNGFGTVVNA LGKRVKPYLP QICGTVLWRL NNKSAKVRQQ AADLISRTAV
970 980 990 1000 1010 1020
VMKTCQEEKL MGHLGVVLYE YLGEEYPEVL GSILGALKAI VNVIGMHKMT PPIKDLLPRL
1030 1040 1050 1060 1070 1080
TPILKNRHEK VQENCIDLVG RIADRGAEYV SAREWMRICF ELLELLKAHK KAIRRATVNT
1090 1100 1110 1120 1130 1140
FGYIAKAIGP HDVLATLLNN LKVQERQNRV CTTVAIAIVA ETCSPFTVLP ALMNEYRVPE
1150 1160 1170 1180 1190 1200
LNVQNGVLKS LSFLFEYIGE MGKDYIYAVT PLLEDALMDR DLVHRQTASA VVQHMSLGVY
1210 1220 1230 1240 1250 1260
GFGCEDSLNH LLNYVWPNVF ETSPHVIQAV MGALEGLRVA IGPCRMLQYC LQGLFHPARK
1270 1280 1290 1300
VRDVYWKIYN SIYIGSQDAL IAHYPRIYND DKNTYIRYEL DYIL
Isoforms
- Isoform 2 of Splicing factor 3B subunit 1Sequence View
10 20 30 40 50 60
MAKIAKTHED IEAQIREIQG KKAALDEAQG VGLDSTGYYD QEIYGGSDSR FAGYVTSIAA
70 80 90 100 110 120
TELEDDDDDY SSSTSLLGQK KPGYHAPVAL LNDIPQSTEQ YDPFAEHRPP KIADREDEYK
130 140 150 160 170 180
KHRRTMIISP ERLDPFADGG KTPDPKMNAR TYMDVMREQH LTKEEREIRQ QLAEKAKAGE
190 200 210 220 230 240
LKVVNGAAAS QPPSKRKRRW DQTADQTPGA TPKKLSSWDQ AETPGHTPSL RWDETPGRAK
250 260 270 280 290 300
GSETPGATPG SKIWDPTPSH TPAGAATPGR GDTPGHATPG HGGATSSARK NRWDETPKTE
310 320 330 340 350 360
RDTPGHGSGW AETPRTDRGG DSIGETPTPG ASKRKSRWDE TPASQMGGST PVLTPGKTPI
370 380 390 400 410 420
GTPAMNMATP TPGHIMSMTP EQLQAWRWER EIDERNRPLS DEELDAMFPE GYKVLPPPAG
430 440 450 460 470 480
YVPIRTPARK LTATPTPLGG MTGFHMQTED RTMKSVNDQP SGNLPFLKPD DIQYFDKLLV
490 500 510 520 530 540
DVDESTLSPE EQKERKIMKL LLKIKNGTPP MRKAALRQIT DKAREFGAGP LFNQILPLLM
550 560 570 580 590 600
SPTLEDQERH LLVKVIDRIL YKLDDLVRPY VHKILVVIEP LLIDEDYYAR VEGREIISNL
610 620 630 640 650 660
AKAAGLATMI STMRPDIDNM DEYVRNTTAR AFAVVASALG IPSLLPFLKA VCKSKKSWQA
670 680 690 700 710 720
RHTGIKIVQQ IAILMGCAIL PHLRSLVEII EHGLVDEQQK VRTISALAIA ALAEAATPYG
730 740 750 760 770 780
IESFDSVLKP LWKGIRQHRG KGLAAFLKAI GYLIPLMDAE YANYYTREVM LILIREFQSP
790 800 810 820 830 840
DEEMKKIVLK VVKQCCGTDG VEANYIKTEI LPPFFKHFWQ HRMALDRRNY RQLVDTTVEL
850 860 870 880 890 900
ANKVGAAEII SRIVDDLKDE AEQYRKMVME TIEKIMGNLG AADIDHKLEE QLIDGILYAF
910 920 930 940 950 960
QEQTTEDSVM LNGFGTVVNA LGKRVKPYLP QICGTVLWRL NNKSAKVRQQ AADLISRTAV
970 980 990 1000 1010 1020
VMKTCQEEKL MGHLGVVLYE YLGEEYPEVL GSILGALKAI VNVIGMHKMT PPIKDLLPRL
1030 1040 1050 1060 1070 1080
TPILKNRHEK VQENCIDLVG RIADRGAEYV SAREWMRICF ELLELLKAHK KAIRRATVNT
1090 1100 1110 1120 1130 1140
FGYIAKAIGP HDVLATLLNN LKVQERQNRV CTTVAIAIVA ETCSPFTVLP ALMNEYRVPE
1150 1160 1170 1180 1190 1200
LNVQNGVLKS LSFLFEYIGE MGKDYIYAVT PLLEDALMDR DLVHRQTASA VVQHMSLGVY
1210 1220 1230 1240 1250 1260
GFGCEDSLNH LLNYVWPNVF ETSPHVIQAV MGALEGLRVA IGPCRMLQYC LQGLFHPARK
1270 1280 1290 1300
VRDVYWKIYN SIYIGSQDAL IAHYPRIYND DKNTYIRYEL DYIL
Protein Neighborhood
Domains & Features
28 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O75533-1-unknown | MAKIAK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O75533-1-unknown | MAKIAK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt89389 | |||
O75533-2-acetylation | AKIAKT... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
O75533-2-acetylation | AKIAKT... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
O75533-2-acetylation | AKIAKT... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt163000 | ||
O75533-35-unknown | STGYYD... | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10953 | |||
O75533-35-unknown | STGYYD... | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt137993 | |||
O75533-35- | STGYYD... | 35 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75533-35- | STGYYD... | 35 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75533-35- | STGYYD... | 35 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75533-35- | STGYYD... | 35 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O75533-35- | STGYYD... | 35 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-37- | GYYDQE... | 37 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75533-37-unknown | GYYDQE... | 37 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170519 | |||
O75533-38- | YYDQEI... | 38 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75533-38- | YYDQEI... | 38 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O75533-38-unknown | YYDQEI... | 38 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170517 | |||
O75533-43- | IYGGSD... | 43 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
O75533-43-unknown | IYGGSD... | 43 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O75533-43-unknown | IYGGSD... | 43 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162100 | |||
O75533-57- | SIAATE... | 57 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75533-57-unknown | SIAATE... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175010 | |||
O75533-183-unknown | VVNGAA... | 183 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O75533-183- | VVNGAA... | 183 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75533-183- | VVNGAA... | 183 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
O75533-183- | VVNGAA... | 183 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75533-183- | VVNGAA... | 183 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-239- | AKGSET... | 239 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
O75533-241- | GSETPG... | 241 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O75533-305-unknown | GHGSGW... | 305 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O75533-305-unknown | GHGSGW... | 305 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apopotic_Jurkat_FasL | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O75533-305- | GHGSGW... | 305 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-309- | GWAETP... | 309 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O75533-309-unknown | GWAETP... | 309 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O75533-319-unknown | GGDSIG... | 319 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9908 | |||
O75533-322-unknown | SIGETP... | 322 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10955 | |||
O75533-433- | ATPTPL... | 433 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75533-433- | ATPTPL... | 433 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
O75533-433- | ATPTPL... | 433 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O75533-433- | ATPTPL... | 433 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-439-unknown | GGMTGF... | 439 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13845 | |||
O75533-440- | GMTGFH... | 440 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O75533-440- | GMTGFH... | 440 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-455- | SVNDQP... | 455 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
O75533-455- | SVNDQP... | 455 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
O75533-455- | SVNDQP... | 455 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
O75533-484-unknown | ESTLSP... | 484 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10956 | |||
O75533-914-unknown | FGTVVN... | 914 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3300 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GVGLDS | 34 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10953 | |||
...GVGLDS | 34 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121004 | |||
...PRTDRG | 318 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9908 | |||
...DRGGDS | 321 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10955 | |||
...TPTPLG | 438 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13845 | |||
...LVDVDE | 483 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10956 | |||
...VMLNGF | 913 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC3300 | |||
...LDYIL | 1304 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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