P11940: Polyadenylate-binding protein 1

General Information

Protein names	- Polyadenylate-binding protein 1 - PABP-1 - Poly(A)-binding protein 1
Gene names	PABPC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P11940

13 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ
        70         80         90        100        110        120
QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS
       130        140        150        160        170        180
AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE
       190        200        210        220        230        240
AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER
       250        260        270        280        290        300
HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN
       310        320        330        340        350        360
LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT
       370        380        390        400        410        420
KPLYVALAQR KEERQAHLTN QYMQRMASVR AVPNPVINPY QPAPPSGYFM AAIPQTQNRA
       430        440        450        460        470        480
AYYPPSQIAQ LRPSPRWTAQ GARPHPFQNM PGAIRPAAPR PPFSTMRPAS SQVPRVMSTQ
       490        500        510        520        530        540
RVANTSTQTM GPRPAAAAAA ATPAVRTVPQ YKYAAGVRNP QQHLNAQPQV TMQQPAVHVQ
       550        560        570        580        590        600
GQEPLTASML ASAPPQEQKQ MLGERLFPLI QAMHPTLAGK ITGMLLEIDN SELLHMLESP
       610        620        630
ESLRSKVDEA VAVLQAHQAK EAAQKAVNSA TGVPTV

Isoforms

- Isoform 2 of Polyadenylate-binding protein 1

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P11940-1-Acetylation	MNPSAP...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P11940-1-Acetylation	MNPSAP...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95767
P11940-1-unknown	MNPSAP...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84133
P11940-14-	YVGDLH...	14			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11940-14-	YVGDLH...	14			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P11940-14-unknown	YVGDLH...	14		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171627
P11940-142-unknown	FVHFET...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3621
P11940-142-unknown	FVHFET...	142		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144396
P11940-486-	STQTMG...	486			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P11940-497-	AAAAAT...	497			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11940-498-	AAAATP...	498			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P11940-507-	TVPQYK...	507			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P11940-546-unknown	TASMLA...	546		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13967
P11940-546-unknown	TASMLA...	546		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152873
P11940-590-unknown	NSELLH...	590		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11191
P11940-590-unknown	NSELLH...	590		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153424
P11940-621-unknown	EAAQKA...	621			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P11940-621-unknown	EAAQKA...	621		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt160033
P11940-621-	EAAQKA...	621			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SKGYGF	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3621
...SKGYGF	141	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127659
...GQEPLT	545	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13967
...LLEIDN	589	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11191
...LLEIDN	589	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136847
...GVPTV	636	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GVPTV	636	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79751

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	141	GYGF.\|.FVHF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	545	EPLT.\|.TASM	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	589	EIDN.\|.NSEL	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)