P20700: Lamin-B1

General Information

Protein names	- Lamin-B1
Gene names	LMNB1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20700

11 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL
        70         80         90        100        110        120
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN
       130        140        150        160        170        180
YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA
       190        200        210        220        230        240
KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY
       250        260        270        280        290        300
KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI
       310        320        330        340        350        360
ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY
       370        380        390        400        410        420
EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD
       430        440        450        460        470        480
VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV
       490        500        510        520        530        540
SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA
       550        560        570        580
QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P20700-2-unknown	MATATP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20700-2-Acetylation	ATATPV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P20700-2-Acetylation	ATATPV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P20700-2-Acetylation	ATATPV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P20700-2-Acetylation	ATATPV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P20700-80-	ALYETE...	80			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20700-80-	ALYETE...	80			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P20700-147-	AALATA...	147			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20700-210-	SMYEEE...	210			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20700-210-	SMYEEE...	210			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P20700-210-	SMYEEE...	210			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20700-232-unknown	SGRQIE...	232		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11325
P20700-232-unknown	SGRQIE...	232		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1687
P20700-232-unknown	SGRQIE...	232		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2546
P20700-279-	SEMNTS...	279			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P20700-288-	SAREEL...	288			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20700-305-	SQLSNL...	305			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P20700-403-unknown	ASSSRS...	403		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10030
P20700-520-	SWGTGE...	520			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P20700-520-	SWGTGE...	520			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P20700-520-	SWGTGE...	520			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LVEVDS	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11325
...LVEVDS	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1687
...LVEVDS	231	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2546
...GEEERL	387	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000378761
...VTVSRA	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10030
...SNRSCA	583	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	231	EVDS.\|.SGRQ	inferred from experiment	unknown	MEROPS	Lieberman J	Zhang D et al.:Granzymes A and B directly clea... (C14.005)	11331782,
CASP3_HUMAN	231	EVDS.\|.SGRQ	inferred from experiment	unknown	MEROPS	Liu R	Ju W et al.:Proteome-wide identification of... (C14.003)	17728405,
CASP6_HUMAN	231	EVDS.\|.SGRQ	inferred from experiment	unknown	MEROPS	Lieberman J	Zhang D et al.:Granzymes A and B directly clea... (C14.005)	11331782,
GRAA_HUMAN	402	VSRA.\|.ASSS	inferred from experiment	unknown	MEROPS	Lieberman J	Zhang D et al.:Granzymes A and B directly clea... (C14.005)	11331782,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)